CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

Research Highlights

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    Musa paradisiaca inflorescence induces human colon cancer cell death by modulating cascades of transcriptional events

    Colorectal cancer (CRC) is one of the leading causes of cancer death with diet playing an important role in etiology of CRC. Traditional medical practitioners in many of the South Asian Countries use plantain inflorescence for the treatment of various gastro-intestinal ailments. The aim of the present study is to investigate the anticancer effect of [...]

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    BF3•OEt2 Mediated Tandem Annulation: A Strategy to Construct Functionalized Chromeno-, and Pyrano- Fused Pyridines

    A simple and efficient one-pot annulation of arylidenones, alkynes, and nitriles in the presence of BF3.OEt2 is described. A highly functionalized variety of N-substituted pyridine fused-, chromeno and pyrano derivatives obtained with satisfactory yields under mild reaction conditions. The method was proven to be valid for the synthesis of the diverse library of chromeno [3,4-c]pyridines, [...]

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    Epoxyazadiradione purified from the Azadirachta indica induced mitochondrial apoptosis and inhibition of NFκB nuclear translocation in human cervical cancer cells

    Epoxyazadiradione (EAD) is an important limonoid present in Neem (Azadirachta indica) plant. In the present study, we have purified EAD from Neem seed and studied its anticancer potential in human cervical cancer (HeLa) cells. Cell proliferation inhibition studies indicated that the GI50 value of EAD is 7.5 ± 0.0092 μM in HeLa cells, whereas up [...]

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    Self assembly of Oleylamine modified nano-fibrillated cellulose from areca husk fibers into giant vesicles

    Nanotechnology involving cellulosic substrates has generated a great attention owing to their exceptional physical and chemical properties. Self-assembled nanostructures obtained from carbohydrate polymers are of interest in the biomedical field for the biocompatibility and non-toxic nature. In the present study modification of nano-fibrillated cellulose (NFC) synthesized from the husk fibers of Areca catechu nuts (AHF) [...]

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    A Supramolecular Nanocomposite as a Near-Infrared Transmitting Optical Filter for Security and Forensic Applications

    Visibly opaque but near-infrared (NIR)-transparent materials are an essential component for night-vision photography, security imaging, and forensic applications. Herein, the development of a novel supramolecular black dye from a diketopyrrolopyrrole (DPP)-based low-molecular-weight organogelator is described. In the solution state, the monomer of DPP–Amide exhibits a deep green color with a broad absorption in the visible [...]

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    One-Pot MCR-Oxidation Approach toward Indole – Fused Heteroacenes

    A straightforward synthetic route toward indole-fused heteroacenes was developed. The strategy is composed of a one-pot process starting with a multicomponent reaction of cyclohexanone, primary amine and N-tosyl-3-nitroindole followed by an oxidation step. The one-pot approach was found to be general, affording both symmetric and nonsymmetric indolo[3,2-b]indoles in good yields. The strategy was also utilized [...]

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    Heteroannulation of 3- Nitroindoles and 3 – Nitrobenzo[b]thiophenes: A Multicomponent Approach toward Pyrrole-Fused Heterocycles

    P. V. Santhini, Sheba Ann Babu, Akhil Krishnan R., E. Suresh, and Jubi John*
    A simple, efficient, and general multicomponent reaction involving an enolizable ketone, a primary amine, and an N-protected 3-nitroindole was developed for the synthesis of a range of functionalized pyrrolo[3,2-b]indoles. The methodology was efficaciously utilized for the “pyrroloindoliztion” of natural products, the [...]

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    An Unprecedented Amplification of Near- Infrared Emission in a Bodipy Derived -System by Stress or Gelation

    Sandeep Cherumukkil, Samrat Ghosh, Vakayil K. Praveen, and Ayyappanpillai Ajayaghosh*
    We report an unprecedented strategy to generate and amplify near-infrared (NIR) emission in an organic chromophore by mechanical stress or gelation pathways. A greenish-yellow emitting film of -extended Bodipy-1, obtained from n-decane, became orange-red upon mechanical shearing, with a 15-fold enhancement in NIR emission at [...]

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    The Helix to Super-Helix Transition in the Self-Assembly of π-Systems: Superseding of Molecular Chirality at Hierarchical Level

    Mohamed Hifsudheen, Rakesh K. Mishra, Balaraman Vedhanarayanan, Vakayil K. Praveen,* and Ayyapanpillai Ajayaghosh*
    Higher-order super-helical structures derived from biological molecules are known to evolve through opposite coiling of the initial helical fibers, as seen in collagen protein. A similar phenomenon is observed in a -system self-assembly of chiral oligo(phenyleneethylene) derivatives (S)-1 and (R)-1 that explains the [...]

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    Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect.

    Thomas Sithara1, 2, K. B. Arun1, H. P. Syama1, T. R. Reshmitha1, 2 and P. Nisha1, 2 *
    The study under investigation focuses on in vitro antiproliferative efficacy of the flavonoid morin and the mechanisms by which it inhibits the growth of colon cancer using SW480 colon cancer cells with emphasis on Warburg effect. It was [...]

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