CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

Research Highlights

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    MesoTetraki N-confused Porphyrin Tetrasodium Salt: A Potential Sensitizer for Photodynamic Therapy

    A water soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photo-physical and invitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC50 values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. [...]

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    Synthesis and characterization of gold nanoparticle -cored dendrimers stabilized by metal-carbon bonds

    Synthesis of gold nanoparticle-cored dendrimers (NCDs), where the dendrons are attached to the gold core through gold-carbon bonds involved the simultaneous reduction of HAuCl4 and a Fréchet-type dendron with a diazonium group at the focal point, in an organic solvent such as toluene. These materials possessed a nanometer-sized gold core surrounded by a shell of [...]

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    Recognition of 5’-GMP through a supramolecular assembly

    Organized assembly of molecules through non-covalent interactions is a powerful tool for generating defined molecular architectures. Although such assemblies have been effectively utilized in host–guest chemistry, metallocyclophanes have rarely been utilized as receptors for nucleotides in aqueous solution. Of all the nucleotides, the recognition of guanosine 5’-monophosphate (5’-GMP) is vital because it acts as an [...]

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