CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

Research Highlights

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    Self-Assembled Near-Infrared Dye Nanoparticles as a Selective Protein Sensor by Activation of a Dormant Fluorophore

    Palapuravan Anees, Sivaramapanicker Sreejith,and Ayyappanpillai Ajayaghosh
    Design of selective sensors for a specific analyte in blood serum,which contains a large number of proteins, small molecules, and ions, isimportant in clinical diagnostics. While metal and polymeric nanoparticleconjugates have been used as sensors, small molecular assemblies have rarelybeen exploited for the selective sensing of a protein in blood [...]

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    New insight of squaraine-based biocompatible surface enhanced Raman scattering nanotag for cancer-cell imaging

    Development of highly sensitive diagnostic nanoprobe for cancer imaging based on surface enhanced Raman scattering (SERS) platform. SERS nanotag Au-LSL-PEG showed significant signal intensity and remarkable stability. Anti- EGF and anti-Her2 antibody are conjugated to Au-LSL-PEG-nanotag which has been successfully applied for selective recognition of cancer cells viz., A549, OSCC and MCF7.The newly developed SERS-nanotag [...]

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    Novel Lysosome Targeted Molecular Transporter Built On A Guanidinium-Poly-(Propylene Imine) Hybrid Dendron For Efficient Delivery Of Doxorubicin Into Cancer Cells

    An efficient synthetic approach has been adopted to construct a new dendron-based octa-guanidine appended molecular transporter with a lysosomal targeted peptide–doxorubicin conjugate. The transporter alone (G8-PPI-FL) is found to be non-toxic, showed higher cellular uptake compared to Arg-8-mer and exhibited excellent selectivity towards lysosomes in cathepsin B expressing HeLa cells, while the Dox-conjugate showed significant [...]

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    Aligned 1-D Nanorods of a π-Gelator Exhibit Molecular Orientation and Excitation Energy Transport Different from Entangled Fiber Networks

    Linear π-gelators self-assemble into entangled fibers in which the molecules are arranged perpendicular to the fiber long axis. However, orientation of gelator molecules in a direction parallel to the long axes of the one-dimensional (1-D) structures remains challenging. Herein we demonstrate that, at the air–water interface, an oligo(p-phenylenevinylene)-derived π-gelator forms aligned nanorods of 340 [...]

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    Supergelation via Purely Aromatic π–π Driven Self-Assembly of PseudodiscoticOxadiazoleMesogens

    A series of highly luminescent oxadiazole-based stilbene molecules (OXD4, OXD8, OXD10, and OXD12) exhibiting interesting enantiotropic liquid crystalline and gelation properties have been synthesized and characterized. The molecules possessing longer alkyl substituents, OXD10 and OXD12, possess a pseudodisc shape and are capable of behaving as supergelators in nonpolar solvents, forming self-standing gels with very high [...]

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    Palladium Catalyzed Skeletal Rearrangement of Spiro tricyclic Olefins: A facile One Pot Strategy for the Synthesis of a Novel Motif with Cyclopentene Fused to Benzofuran and Pyrazolidine

    An efficient one pot strategy for the synthesis of a novel framework of benzofuran-pyrazolidine fused cyclopentenes by a palladium catalyzed tandem reaction of cyclopropane-bearing spirotricyclic olefins with 2-iodophenols is reported. In the case of 2-iodoanilines, the protocol afforded functionalized spiro[2.4]-hept-4-enes. ,Chemistry–A European Journal, DOI:10.1002/chem.201301475

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    Palladium/Lewis Acid Mediated Domino Reaction of Pentafulvene Derived Diazabicyclic Olefins: Efficient Access to Spiropentacyclic Motif with an Indoline and Pyrazolidine fused to Cyclopentene

    Palladium/Lewis acid mediated stepwise and one pot transformation of pentafulvene derived diazabicyclic olefins is described. The reaction offers a facile strategy for the synthesis of novel spiropentacyclic motifs with indoline and pyrazolidine fused to cyclopentene core.Org. Lett. DOI: 10.1021/ol401374d

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    Squaraine dyes in PDT: from basic design to in vivo demonstration

    The design and development of novel squaraine dyes as sensitisers for photodynamic therapy (PDT) applications has grown tremendously in the last decade from the time when a squaraine dye was proposed to be a potential candidate, to-date when the use of such dyes have been demonstrated in animal models for skin cancer. This perspective article [...]

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    Attogram Sensing of Trinitrotoluene with a Self-Assembled Molecular Gelator

    Detection of explosives is of utmost importance due to the threat to human security as a result of illegal transport and terrorist activities. Trinitrotoluene (TNT) is awidely used explosive in landmines and military operations that contaminates the environment and groundwater, posing a threat to human health. Achieving the detection of explosives at a sub-femtogram level [...]

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    Improved Dielectric and Mechanical Properties of Polystyrene Hybrid Silica Sphere Composite Induced through Bifunctionalization at the Interface

    Hybrid silica spheres (HS) of size 270−350 nm with vinyl and aminopropyl surface groups were incorporated in polystyrene (PS), and its effect on dielectric properties, coefficient of thermal expansion (CTE), and strength of PS−HS composite was studied. Incorporation of HS in PS followed a decrease in the dielectric constant from 3.2 for PS to 2.6 [...]

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