CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

Antibacterial and anti tubercular evaluation of dihydronaphthalenone-indole hybrid analogues

Praveen Kumar. V, Renjitha. J, Fathimath Salfeena. C.T, Ashitha. K.T, Sunil Varughese, B. S. Sasidhar*

A new series of indole appended dihydronaphthalenone hybrid analogues have been synthesized through the Lewis acid catalyzed Michael addition of indoles to the arylidene/hetero arylidene ketones. All the synthesized derivatives are well characterized through the 1H-NMR, 13C-NMR, HRMS spectroscopic techniques and further confirmed through single crystal X-ray analysis and screened for antibacterial and anti-tubercular activities. Among the synthesized compounds, the minimum inhibition concentration of 5l (against E.coli) and 5o & 5p (against E.coli & S.aureus) was found to be as low as 3.12 µgmL-1 as compared to the standard antibacterial drug Ciprofloxacin 2.5 µgmL-1. In anti-tubercular activity, compound 5o and 5p with minimum inhibition concentration 6.25 µgmL-1 was found to be comparable with that of the drugs Pyrazinamide 5 µgmL-1 and Streptomycin 5 µgmL-1.

Chemical Biology and Drug Design, 2017

DOI: 10.1111/cbdd.12990

Link: http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12990/abstract