Research Highlights

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  • BF3•Et2O mediated one-step synthesis of N -substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines

BF3•Et2O mediated one-step synthesis of N -substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines

C. T. Fathimath Salfeena, K. T. Ashithaa, and B. S. Sasidhar*

A simple and efficient one-pot synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines by a BF3•Et2O mediated novel methodology, from easily available α,β-unsaturated ketones/arylidene ketones, phenyl acetylenes and substituted nitriles, has been described. This novel annulation provides quick access to complex polycyclic frameworks with an excellent substrate scope.

Organic and Biomolecular Chemistry, 2016

DOI: 10.1039/c6ob02133f

Link: http://pubs.rsc.org/en/content/articlelanding/2016/ob/c6ob02133f#!divAbstract