CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

EXPLORATION OF BIOGENIC NANO CHEMOBIOTICS FABRICATED BY SILVER NANOPARTICLE AND GALACTOXYLOGLUCAN WITH AN EFFICIENT BIODISTRIBUTIONIN SOLID TUMOR INVESTIGATED BY SERS FINGERPRINTING

Manu M. Joseph,Jyothi B. Nair,Ramya N. Adukkadan,NeethuHari,Raveendran K. Pillai,Ananthakrishnan J. Nair,Kaustabh Kumar Maiti,*and Sreelekha Therakathinal T*

An incredible exploration ensued of a dual modality nanocomposite whereinchemotherapy in fusion with antibacterial efficacy is obtained in a biogenic fabrication, which transformed as a novel nano-chemobiotics (NCB) prevailing fundamental molecular level investigation by surface-enhanced Raman scattering (SERS) platform. The nanocomposite is a facile, robust, and ecofriendly constitution between silver nanoparticles (SNPs) and a naturally occurring galactoxyloglucan (PST001) denoted as SNP@PST, which displayed biocompatibility with an upgraded selective cytotoxicity toward cancer cells. The relatively nontoxic nature of the SNP@PST on normal cells and red blood cells was further proved by detailed toxicological profiling on BALB/c mice. As a unique outcome, we observed excellent antibacterial activity, which is complementary to the greater cytotoxicity by the NCB. In diagnostic aspect, SNP@PST was revealed to be a superior SERS substrate with multiscale Raman signal enhancement contributed by homogeneous hot-spot distribution. Finally, the inherent SERS feature enabled us to investigate the biodistribution of the NCB in tumor-challenged mice using Raman fingerprinting and mapping analysis. Hence, the unrevealed SNP@PST orchestrated with the surfactant-free green method resembled a potential theransonstic NCB construct with synergistic anticancer and antibacterial potential in a single platform.

ACS Appl. Mater. Interfaces2017, 9, 19578−19590