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  • MesoTetraki N-confused Porphyrin Tetrasodium Salt: A Potential Sensitizer for Photodynamic Therapy

MesoTetraki N-confused Porphyrin Tetrasodium Salt: A Potential Sensitizer for Photodynamic Therapy

A water soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photo-physical and invitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC50 values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques (J.Med.Chem.2012, 55, 5110-5120).