CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

Nucleoside Diphosphate Kinase of Mycobacterium : Structural & Functional Insights

 

Dr. M. Arumugam on 14th August 2014 at 10:45 am

Nucleoside diphosphate kinase (NDK) is an essential enzyme present in a wide range of organisms, with the gene and its structure highly conserved. NDK utilises an autophosphorylated enzyme intermediate to catalyse the transfer of 5’ terminal phosphate from NTPs to nucleoside diphosphates (NDPs), which therefore get converted to the respective NTPs. in addition to its primary role to maintain the cellular NTP pool, it also involved in cellular regulatory functions such as growth and developmental control, tumor metastasis suppression and signal transduction. The recent advancement in structural and functional role of NDK will be discussed.