CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

Polymorphs, Pills & Patents From a chemist’s point of view


Dr. Sunil Varughese, CSTD on 21st January 2015 at 2:30 pm

Polymorphism, the ability of a substance to exist in more than one crystal form, has grown in importance over the last few years. While polymorphism as a phenomenon is prevalent in every industry, the influence in pharmaceutics has attracted immense attention thanks to the fundamental and commercial ramifications as well as the economic factors involved. Because many formulations like pills and tablets contain the active ingredient in solid form and also the crystal structure of a compound can influence many properties like solubility, hygroscopicity, chemical stability, etc., it is essential to screen, characterize and identify the optimum solid state form for therapeutic use. The talk will highlight the effect of polymorphism in materials, drugs in particular, and some patent cases pertaining to drug polymorphism.