CSIR – National Institute for Interdisciplinary Science and Technology (NIIST)

Council of Scientific & Industrial Research (CSIR), Govt.Of India Thiruvananthapuram.

Study of cavity size and nature of bridging units on recognition of nucleotides by cyclophanes

Study of cavity size and nature of bridging units on recognition of nucleotides by cyclophanes(Org. Biomol. Chem., 2011, 9, 1021-1029.). Cyclophanes  containing anthracene units linked together through different bridging and spacer groups have been synthesized and investigated their interactions with various nucleosides and nucleotides. They showed selectivity for 5′-GTP and 5′-ATP as compared to other nucleotides and nucleosides and exhibited significant binding interactions with the fluorescent indicator, 8-hydroxy-1,3,6-pyrene trisulfonate (HPTS), resulting in the formation of non-fluorescent complexes.

http://dx.doi.org/10.1039/C0OB00673D