Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair
B. Prabha, S. Neethu, S. Lekshmy Krishnan, D. R. Sherin, M. Madhukrishnan, R. Ananthakrishnan, K. B. Rameshkumar,* T. K. Manojkumar,* P. Jayamurthy* and K. V. Radhakrishnan*
Phytochemical investigation of the stem bark of Myristica fatua Houtt. led to the isolation of a new compound 1 (3-tridecanoylbenzoic acid), along with six known acylphenols (2–7). All the compounds displayed moderate inhibitory activity on ?-amylase and significant activity on ?-glucosidase; however malabaricone B (6) and C (7) were identified as potent ?-glucosidase inhibitors with IC50 values of 63.70?±?0.546, and 43.61?±?0.620?µM respectively. Acylphenols (compounds 3–7) also showed significant antiglycation property. The molecular docking and dynamics simulation studies confirmed the efficient binding of malabaricone C with C-terminus of human maltase-glucoamylase (2QMJ). Malabaricone B also enhanced the 2-NBDG [2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy glucose] uptake in L6 myotubes. These findings demonstrate that acylphenols isolated from Myristica fatua Houtt. can be considered as a lead scaffold for the treatment of type II diabetes mellitus.
Bioorganic & Medicinal Chemistry, 2018, 26, 3461-3467.