I2/TBHP Mediated Diastereoselective Synthesis of Spiroaziridines
Kizhakkan Thiruthi Ashitha, Puthiya Purayil Vinaya, Ajay Krishna, Deepthy Cheeran Vincent, Renjitha Jalaja, Sunil Varughese, Sasidhar Balappa Somappa*
Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible ?, ?-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines as well.
Org. Biomol. Chem., 2020, 18, 1588.