Organic Chemistry - I2/TBHP Mediated Diastereoselective Synthesis of Spiroaziridines 

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I2/TBHP Mediated Diastereoselective Synthesis of Spiroaziridines

Kizhakkan Thiruthi Ashitha, Puthiya  Purayil Vinaya, Ajay Krishna, Deepthy Cheeran Vincent, Renjitha Jalaja, Sunil Varughese, Sasidhar Balappa Somappa*

Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible ?, ?-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines as well.

Org. Biomol. Chem., 2020, 18, 1588.

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