Pd-Catalyzed oxidative annulation of enamides with diazabicyclic olefins: rapid access to cyclopentene fused 2-pyrrolines
P. V. Santhini, G. Nimisha, Jubi John,* E. Suresh, R. Luxmi Varma, K. V. Radhakrishnan*
An efficient stereoselective route for the synthesis of cyclopentene fused 2-pyrrolines has been established via a Pd-catalyzed C–H activation/oxidative coupling of aryl enamides with diazabicyclic olefins. The proposed two-stage mechanism was successfully proven by isolating the intermediate trans-disubstituted cyclopentene.
Chemical Communications, 2017, 53, 1848-1851.
A catalytic tandem transformation via C-H activation of enamides for the stereoselective synthesis of cyclopentene fused 2-pyrrolines has been realized.