B. Prabha, S. Neethu, S. Lekshmy Krishnan, D. R. Sherin, M. Madhukrishnan, R. Ananthakrishnan, K. B. Rameshkumar,* T. K. Manojkumar,* P. Jayamurthy* and K. V. Radhakrishnan*
Phytochemical investigation of the stem bark of Myristica fatua Houtt. led to the isolation of a new compound 1 (3-tridecanoylbenzoic acid), along with six known acylphenols (2–7). All the compounds displayed moderate inhibitory activity on ?-amylase and significant activity on ?-glucosidase; however malabaricone B (6) and C (7) were identified as potent ?-glucosidase inhibitors with IC50 values of 63.70?±?0.546, and 43.61?±?0.620?µM respectively. Acylphenols (compounds 3–7) also showed significant antiglycation property. The molecular docking and dynamics simulation studies confirmed the efficient binding of malabaricone C with C-terminus of human maltase-glucoamylase (2QMJ). Malabaricone B also enhanced the 2-NBDG [2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy glucose] uptake in L6 myotubes. These findings demonstrate that acylphenols isolated from Myristica fatua Houtt. can be considered as a lead scaffold for the treatment of type II diabetes mellitus.
Bioorganic & Medicinal Chemistry, 2018, 26, 3461-3467.