Synthesis of novel pyrazolyl-1, 3, 4-thiadiazole analogues
NINGAIAH (S), BHADRAIAH (U K), SOBHA (A), SHRIDEVI (D)
amide linkage; pyrazole; Lawesson’s reagent; x-ray crystallography; 134-thiadiazole
Polycyclic Aromatic Compounds
42(4):1249 - 1259
In the present study, we have designed a novel series of pyrazolyl-1,3,4-thiadiazole analogues by accommodating 1,3,4-thiadiazole ring at C – 4 of pyrazole ring with and without an amide linkage; 5-methyl-1,3-diphenyl-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-4-carboxamide and 2-(5-methyl-1,3-diphenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-thiadiazole respectively. We have designed this class of heterocycles by keeping a wide audience in mind, which augment their scientific knowledge. Newly synthesized compounds were characterized by 1H NMR, 13C NMR, mass, IR spectral studies. Single crystal X-ray analysis of some compounds also gave insight into the structural information.