Highlights

  • Natural Products Chemistry

    Harnessing the natural wealth (plant/herbal) of the region to obtain novel biologically active compounds or leads for drug synthesis, exploring traditional systems of medicine including Ayurveda, Siddha and tribal medicine for lead structures and correlating/corroborating this wealth of knowledge with modern diagnostic chemical and biological testing methods. Under natural products program specific attention is given to the discovery of antioxidants, antiobesity, antidiabetic, antiviral, anti-inflammatory agents and anticancer compounds. Natural products are also synthetically modified and studied for the changes/enhancement in biological activities. We are also creating a library of phytochemical markers/standards to support the quality control/standardization of herbal raw materials and finished products.We are also strengthening our capability to develop technically and commercially suitable galenical formulations of traditional medicines.

  • Synthesis of Bioactive Molecules

    Design and synthesis of bioactive molecules which includes small molecule-based antimicrobials,heterocycle based anticancer agents,neoglycoconjugates, nucleoside phosphonates as antivirals &synthetic plant growth promoters for improved crop productivity and soil fertility.

  • Development of Novel Reactions/Reagents

    The central theme of organic synthesis is making and breaking of bonds in a selective and controlled fashion by focusing on reactive intermediates like cation and anion radicals, carbenes/carbenoids, ylides, dipoles etc. We employ pericyclic, chemical electron transfer, tin mediated radical cyclization reactions, multicomponent reactions, organo-and metal-catalyzedreactions in the above program. Several transformations based on these ideas have been developed.

  • Chemical Biology Approach towards Molecular and Nano-carrier Probe Development

    In this area an interdisciplinary team is working on versatile molecular probe development involving fluorescence and Raman modality and investigates their efficiency for sensitive detection of different bio-analytes, biomarkers in cancer and neurodegenerative diseases.   Secondly, the interdisciplinary team is working on development of synthetic (peptide, non-peptide, macro cyclic  scaffold ) and nano-carrier based targeted drug-delivery system (TDDS) towards cancer therapy and neurological disease treatment.

  • Solid State and Supramolecular Structural Chemistry

    Our research focuses on developing materials with unique fluorescent and mechanical properties and drawing structure-property correlations to comprehend the underlying molecular arrangements that contribute to the crystal property. We use crystal engineering strategies to develop solid forms of active pharmaceutical ingredients (APIs) with enhanced activity and optimal plasticity to attain better tabletability.

  • Green Chemical Techniques and Catalysts

    Research in Green chemical techniques on account of the future needs of advanced Chemical Technologies to be economical, safe, environmentally benign as well as resource and energy saving. In this line, we also design and fabricate heterogeneous catalysts (with high TON & TOF) from cheap and easily available materials like clay/magnesium phyllosilicate for organic transformations.

Research Highlights

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Moments of Workshop

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