Highlights

  • Natural Products Chemistry

    Harnessing the natural wealth (plant/herbal) of the region to obtain novel biologically active compounds or leads for drug synthesis, exploring traditional systems of medicine including Ayurveda, Siddha and tribal medicine for lead structures and correlating/corroborating this wealth of knowledge with modern diagnostic chemical and biological testing methods. Under natural products program specific attention is given to the discovery of antioxidants, antiobesity, antidiabetic, antiviral, anti-inflammatory agents and anticancer compounds. Natural products are also synthetically modified and studied for the changes/enhancement in biological activities. We are also creating a library of phytochemical markers/standards to support the quality control/standardization of herbal raw materials and finished products. We are also strengthening our capability to develop technically and commercially suitable galenical formulations of traditional medicines.

  • Synthesis of Bioactive Molecules

    Design and synthesis of bioactive molecules which includes small molecule-based antimicrobials, heterocycle based anticancer agents, neoglycoconjugates, nucleoside phosphonates as antivirals & synthetic plant growth promoters for improved crop productivity and soil fertility.

  • Development of Novel Reactions/Reagents

    The central theme of organic synthesis is making and breaking of bonds in a selective and controlled fashion by focusing on reactive intermediates like cation and anion radicals, carbenes/carbenoids, ylides, dipoles etc. We employ pericyclic, chemical electron transfer, tin mediated radical cyclization reactions, multicomponent reactions, organo-and metal-catalyzed reactions in the above program. Several transformations based on these ideas have been developed.

  • Chemical Biology Approach towards Molecular and Nano-carrier drug delivery system (DDS) and diagnostic nano-probe Development 

    In this area an interdisciplinary team is working at the interface between chemistry, biology and nano science. We are aiming to develop synthetic (peptide, non-peptide, macro cyclic scaffold) and nano-carrier targeted drug-delivery system (TDDS) for the delivery of small molecular drugs, proteins, nucleic acids and plasmid DNAs for combination therapy for both cancer and other non-communicable diseases. Secondly, our interest to develop functionalized nano-particle probes for ultrasensitive detection of various human cancers and other non-communicable disease biomarkers using Raman Scattering (surface enhanced Raman scattering: SERS) and Imaging as a diagnostic modality. Our research effort also focusing on multimodal theranostic nano-probes constructions with SERS, fluorescence, and MRI, as diagnostic modalities and PDT, PTT, chemotherapy as well as immunotherapy for treatment modalities.

  • Development of Pharmaceutical Formulations

    Pharmaceutical formulation development is a multistep process where the active drug is mixed with various excipients to produce a final beneficial medicinal product.  The factors like particle size, polymorphism, pH, and solubility are investigated during performualtion studies. The formulation development team mainly focuses on developing new pharmaceutical formulations from natural bioactives and also generic APIs through indigenous and novel drug delivery methods. Furthermore, scale-up trials, optimization of drug solubility, bioavailability, and production validation are also precisely recorded and monitored because of different drug pharmacokinetics. In addition, analytical methods and standard operating procedures are maintained for the development of quality and consistent products.

  • Solid State and Supramolecular Structural Chemistry

    Our research focuses on developing materials with unique fluorescent and mechanical properties and drawing structure-property correlations to comprehend the underlying molecular arrangements that contribute to the crystal property. We use crystal engineering strategies to develop solid forms of active pharmaceutical ingredients (APIs) with enhanced activity and optimal plasticity to attain better tabletability

  • Green Chemical Techniques and Catalysts

    Research in Green chemical techniques on account of the future needs of advanced Chemical Technologies to be economical, safe, environmentally benign as well as resource and energy saving. In this line, we also design and fabricate heterogeneous catalysts (with high TON & TOF) from cheap and easily available materials like clay/magnesium phyllosilicate for organic transformations.

Research Highlights

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