Research Highlights

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  • Novel Lysosome Targeted Molecular Transporter Built On A Guanidinium-Poly-(Propylene Imine) Hybrid Dendron For Efficient Delivery Of Doxorubicin Into Cancer Cells

Novel Lysosome Targeted Molecular Transporter Built On A Guanidinium-Poly-(Propylene Imine) Hybrid Dendron For Efficient Delivery Of Doxorubicin Into Cancer Cells

An efficient synthetic approach has been adopted to construct a new dendron-based octa-guanidine appended molecular transporter with a lysosomal targeted peptide–doxorubicin conjugate. The transporter alone (G8-PPI-FL) is found to be non-toxic, showed higher cellular uptake compared to Arg-8-mer and exhibited excellent selectivity towards lysosomes in cathepsin B expressing HeLa cells, while the Dox-conjugate showed significant cytotoxicity to cancer cells without affecting the non-cancerous cells. Chem. Commun., 2015, 51, 2403-2406.