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  • Supramolecular Reassembly of Self ‐ Exfoliated Ionic Covalent Organic Nanosheets for Label ‐ Free Detection of Double ‐ Stranded DNA

Supramolecular Reassembly of Self ‐ Exfoliated Ionic Covalent Organic Nanosheets for Label ‐ Free Detection of Double ‐ Stranded DNA

Ionic covalent organic nanosheets (iCONs), a member of the two‐dimensional (2D) nanomaterials family, offer a unique functional platform for a wide range of applications. Herein, we explore the potential of an ethidium bromide (EB)‐based covalent organic framework (EB‐TFP) that self‐exfoliates in water resulting in 2D ionic covalent organic nanosheets (EB‐TFP‐iCONs) for the selective detection of double‐stranded DNA (dsDNA). In an aqueous medium, the self‐exfoliatedEB‐TFP‐iCONsreassemble in the presence of dsDNA resulting in hybridEB‐TFP‐iCONs‐DNAcrystalline nanosheets with enhanced fluorescence at 600 nm. Detailed steady‐state and time‐resolved emission studies revealed that the reassembly phenomenon was highly selective for dsDNA when compared to single‐stranded DNA (ssDNA), which allowed us to use theEB‐TFP‐iCONsas a 2D fluorescent platform for the label‐free detection of complementary DNA strands.

Arindam Mal, Dr. Rakesh K. Mishra, Dr. Vakayil K. Praveen, M. Abdul Khayum, Dr. Rahul Banerjee,

Prof. Dr. Ayyappanpillai Ajayaghosh.

Link: https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201801352

Angewandte Chemie International Edition, Volume:57, Issue:28, Pages:8443-8447