Dr.Radhakrishnan K V

Dr.Radhakrishnan K V

Dr. K. V. Radhakrishnan was born in Kodungallur, Kerala, India. He received his B.Sc. (1986-1989) and M.Sc. (1990-1991) degrees from Christ College, Irinjalakuda, Kerala, India (University of Calicut), and Master of Human Resource Management (MHRM) from University of Kerala with first rank for the year 2014-2016. He obtained his Ph.D. degree in synthetic organic chemistry from the University of Kerala in 1998 under the supervision of Dr. Vijay Nair at CSIR-NIIST, Trivandrum. Subsequently he held postdoctoral positions at Tohoku University, Sendai, Japan, with Professor Yoshinori Yamamoto; at the Molecumetics Institute, Bellevue, WA, with Professor Michael Kahn, and at NPG Research Institute, Raleigh, NC, with Professor Bert Fraser-Reid. He joined CSIR-NIIST as a Scientist in the Chemical Sciences and Technology Division in May 2002. His research interests include the development of novel synthetic methodologies utilizing pentafulvenes as synthons, synthetic carbohydrate chemistry, transition metal-catalyzed organic transformations toward pharmaceutically important molecules, organic photochemistry and phytochemistry with special focus on bioprospecting of medicinal plants from Western Ghats. In addition to the above, he is an active participant in a number of collaborative projects in the process development of functional organic materials, APIs, agrochemicals, chemical intermediates and nutraceutical products for use in a variety of applications. His research group is having interdisciplinary students, both students working for PhD in Chemical Sciences and Biological Sciences.

Achievements & Awards
  • CRSI-2016 Bronze Medal in Chemistry
  • First Rank in Master of Human Resource Management (MHRM) from University of Kerala in 2016
  • MESACAA-UAE Excellence Award 2015 for outstanding contributions in the field of science and inspiring the young generation
  • Excellent rating for Indo-French collaborative project with Université de Reims Champagne-Ardenne, Reims, France
  • Excellent rating for DST sponsored projects in two consecutive terms (2010-13 & 2014-17)
  • Featured in the “TCI-India League of Extra Ordinary Chemists”
  • Council of Scientific and Industrial Research Senior Research fellowship (1995-1998)
  • Council of Scientific and Industrial Research Junior research fellowship (1993)
  • All India lectureship awarded by University Grants Commission, New Delhi, India
  • Dr. M. M. Chandy award for the best student in M.Sc. chemistry (1989-91) from Christ college, Irinjalakuda, Kerala, India
  • Dr. M. P. Kochuvareethu Memorial Award for the best student joined for M. Sc. Chemistry from Trichur district in the year 1989
  • Prof. P. K. Mathew memorial award for the best student in B.Sc. Chemistry (1986-1989) from Christ college, Irinjalakuda, Kerala, India.
Publications

Papers published/in press in peer-reviewed international/national journals

  • Cudraflavone C from Artocarpus hirsutus Lam. as promising inhibitor of pathogenic, multidrug-resistant S. aureus, persisters and biofilms: A new insight into rational explication of traditional Wisdom. M. T. Meenu, K. G. Shukla, S. Manjulika, K. V. Radhakrishnan, C. Sidharth. J. Nat. Prod. Just Accepted.
  • Transition-metal catalyzed reactions of zerumbone for diverse molecular motifs. Mohanan Biji, Bernard Prabha, Ravi S. Lankalapalli, and Kokkuvayil Vasu Radhakrishnan. The Chemical Records. Under Review
  • Bioassay-guided isolation and characterization of potential alpha-glucosidase inhibitors from the seeds of Quassia indica Gaetrn. B. Prabha, M. Biji, M. Madhukrishnan, D. R. Sherin, T. Reshmitha, Sunil Varughese, T. K. Manojkumar, P. Nisha, and K.V. Radhakrishnan. J. Med. Arom. Plant Sci. Under Revision
  • Chemical constituents and their bioactivities of Zingiber nimmoni: An endemic species in South India. Greeshma Gopalan, Hridya Vasantha Kavunkal, Devika Sudha Ravindran, Sabu Mamiyil, Shibi Indira G, Radhakrishnan Kokkuvayil Vasu. J. Med. Arom. Plant Sci. Under Revision
  • Libocedroquinone: A promising anticancer leads against lung cancer from Calcocedrus decurrens (Torr) Florin. Santhi Subramanyan, Varsha Karunakaran, Selvakumar Deepika, Anuja Joseph Gracy, Veluthoor Sheeba, Kaustabh Kumar Maiti, Ramavarma Luxmi Varma, Karchesy Joe Joseph, Kokkuvayil Vasu Radhakrishnan. Planta Med. Under Review
  • Isolation and characterization of oligostilbenoids from Vatica chinensis L. and their ameliorative effect on H2O2 induced oxidative stress in H9c2 cardiomyoblasts. B. Prabha, R. Reshmitha, M. Biji, M. Madhukrishnan, P. Sasikumar, T. Sithara, M. Sabu, P. Nisha, and K. V. Radhakrishnan. Chem. Biol. Drug Des. Under Revision
  • The Renaissance of Electro-Organic Synthesis for the Difuctionalization of Alkenes and Alkynes: A Sustainable Approach. Ditto Abraham Thadathil, Anitha Varghese and Kokkuvayil Vasu Radhakrishnan. Asian J. Org. Chem. 2021 (0000).
  • Anti-proliferative assay guided isolation and molecular docking studies of novel stilbenoids analogue and other pyranoflavonoids from Artocarpus hirsutus Lam. Murugan Thulasi Meenu, Sosmitha Girisa, Vimalkumar Pothiyil Sukumaran, Daisy Rajaian Sherin, Valarukattil  Velayudan Sivan, Thanath Krishnan Manojkumar, Ajaikumar Bahulayan Kunnumakkara, Kokkuvayil Vasu Radhakrishnan. Med. Arom. Plant Sci. Just accepted.
  • Dactyloidin from Myristica fatua Houtt. seed enhances glucose uptake through translocation of GLUT4 via upregulation of AMPK in L6 myotubes. B. Prabha, S. Sini, D. R. Sherin, S. Neethu, M. G. Govind, Mathew Dan, T. K. Manojkumar, P. Jayamurthy, K. V. Radhakrishnan, J. Med. Arom. Plant Sci. Just accepted.
  • Review-Electrochemical strategies for selective fluorination of organic compounds. Ditto Abraham Thadathil, Anitha Varghese, Kokkuvayil Vasu Radhakrishnan, Electrochem. Soc2021, 168, 075503.
  • Mirabijalones S-W, rotenoids from rhizomes of white Mirabilis jalapa and their cell proliferative studies. P. Sharathna V. Alisha P. Sasikumar, Ajesh Vijayan, F. Ayisha, I.G.Shibi, V.V. Sivan, Kaustabh Kumar Maiti , Ravi S. Lankalapalli, K.V. Radhakrishnan, Phytochem. Lett. 2021, 44, 178-184.
  • Tandem photoisomerization and transannular cyclizations of zerumbone epoxide: A model for diversity-oriented synthesis using abundant natural products. Mohanan Biji, Kokkuvayil Vasu Radhakrishnan, Ravi S. Lankalapalli, Lett. 2021, 23, 5871–5875.
  • Phytoconstituents assessment and development of standardization protocol for ‘Nayopayam Kwatha’, a polyherbal Ayurvedic formulation. Ayurveda. Integr. Med. 2021, S0975-9476 (21) 00074-7.
  • Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe. Santhi Subramanyan, Selvakumar Deepika, Anjitha Ajith, Anuja Joseph Gracy, Mathew Dan, Kaustabh Kumar Maiti, Ramavarma Luxmi Varma, Kokkuvayil Vasu Radhakrishnan, Biol. Drug Des. 2021, 00,1-6.
  • Novel flavonoids from the aerial parts of unexplored and endangered wild nutmeg species Myristica beddomei spherocarpa W.J. de Wilde. Neethu S,. Govind M. G, Vimalkumar P S, Biji M, Sherin D R, Mathew Dan, K. V. Radhakrishnan, Phytochem. Lett. 2021, 45, 72-76.
  • A protoberberine alkaloid based ratiometric pH-responsive probe for the detection of diabetic ketoacidosis. Murugan Thulasi Meenu, Anila Rose Cherian, Daisy Rajaian, Aiswarya Raveendran Nair, Thanath Krishnan Manojkumar, Kokkuvayil Vasu Radhakrishnan, Anitha Varghese, Dyes and Pigments2021, 194 (Pt 5):109636
  • Organic Brønsted acid-catalyzed cycloadditions of o-quinone methides with 1, 3-dicarbonlys: Facile access to xanthenones and chromanones. Priyadarshini Thoppe Sivakumar, Sharathna Puthiyaparambath, Sanjay Suresh Varma, Sasikumar Parameswaran, Radhakrishnan Kokkuvayil Vasu, Heterocyclic Chem. 2021, 1-12.
  • Exploring the cytotoxic effects of the extracts and bioactive triterpenoids from Dillenia indica against oral squamous cell carcinoma: A scientific interpretation and validation of indigenous knowledge. Maniyamma Aswathy, Kishore Banik, Dey Parama, Parameswaran Sasikumar, Choudhary Harsha, Anuja Gracy Joseph, Daisy R. Sherin, Manojkumar K. Thanath, Ajaikumar B. Kunnumakkara, Radhakrishnan Kokkuveyil Vasu, ACS Pharmacol. Transl. Sci. 2021, 4, 834-847.
  • Chemoprofiling of Artocarpus camansi and Artocarpus lakoocha Wall. ex. Roxb. and its antidiabetic potential for modulation of digestive enzymes, protein glycation and glucose uptake in L6 myotubes. Sasikumar P, Aswathy M, Lekshmi K, Reshmitha T R, Sharathna P, Sanjay S Varma, Meenu M T, Sivan V V, Nisha P, Jayamurthy, Radhakrishnan K V. J. Med. Arom. Plant Sci. 2020, 42, 1-29.
  • Putative biomimetic route to 8-oxabicyclo[3.2.1]octane motif from a humulene     sesquiterpenoid zerumbone.  Kollery S. Veena, Greeshma Gopalan, Murali Madhukrishnan, Sunil Varughese, Kokkuvayil Vasu Radhakrishnan, and Ravi S. Lankalapalli. Org. Lett. 202022, 6409-6413.
  • Menispermaceae family of plants and its action against infectious diseases: A review. Murugan Thulasi Meenu, Kokkuvayil Vasu Radhakrishnanan, Mapana J. Sciences202019(2), 33-72, doi.org/10.12723/mjs.53.4.
  • Accessing polycyclic terpenoids from zerumbone via Lewis acid catalyzed synthetic strategies. Puthiyaparambath Sharathna, Murugan Thulasi Meenu, Bhandara Purayil Dhanya, Greeshma Gopalan, Parameswaran Sasikumara, Radhakrishnan Syam Krishnana, Kokkuvayil Vasu Radhakrishnan. Synthesis. 2020. DOI: 10.1055/s-0039-1690840
  • Anti-inflammatory effect and mechanism of action of ellagic acid-3, 3′, 4-trimethoxy-4′-O-alpha-L-rhamnopyranoside isolated from Hopea parviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages. B. Prabha, S. Sini, P. Sasikumar, Greeshma Gopalan, Jayesh P Joseph, M. M. Jithin, V. V. Sivan, P. Jayamurthy and K. V. Radhakrishnan. Nat. Prod. Res. 2019, DOI:10.1080/14786419.2019.1690486.
  • Chloroform as a CO surrogate: applications and recent developments. Krishanu Mondal, Pallabi Halder, Greeshma Gopalan, Sasikumar P., K. V. Radhakrishnan and Parthasarathi Das. Org. Biomol. Chem. 2019 DOI: 10.1039/C9OB00886A
  • Isolation and characterization of resveratrol oligomers from the stem bark of Hopea ponga (Dennst.) Mabb. And their antidiabetic effect by modulation of digestive enzymes, protein glycation and glucose uptake in L6 myocytes. Sasikumar PLekshmy KSini SPrabha BKumar N ASivan V VJithin M MJayamurthy PShibi IGRadhakrishnan K VJ Ethnopharmacol.  2019236, 196-204.
  • Promalabaricone B from Myristica fatua Houtt. seeds demonstrate antidiabetic potential by modulating glucose uptake via the upregulation of AMPK in L6 myotubes. B. Prabha, S. Sini, D. R. Sherin, S. Neethu, K. B. Rameshkumar, T. K. Manojkumar, P. Jayamurthy, and K. V. Radhakrishnan. Nat. Prod.  Res. 2019 DOI: 10.1080/14786419.2019.1607852
  • Screening of Musa balbisiana Colla. seeds for antidiabetic properties and isolation of apiforol, a potential lead, with antidiabetic activity. Greeshma Gopalan, B. Prabha, Alfred Joe, T. R. Reshmitha, D. R. Sherin, M. Sabu, T. K. Manojkumar, K. V. Radhakrishnan, and P. Nisha.  J. Sci. Food and Agr. 2019, 99, 2521-2529.
  • GC- MS based chemical profiling of Alpinia manii rhizome -An endemic and endangered plant from Andaman Islands, India. Aswathi P, Madhukrishnan M, Radhakrishnan K V, Sabu M. Pharm. Phytochem. 2018, 7(5), 1807-1809.
  • Rhodium (III)-catalyzed C–H activation/alkylation of diazabicyclic olefins with aryl ketones: Facile synthesis of functionalized cyclopentenes. P. V. Santhini, Greeshma Gopalan, A. S. Smrithy and K. V. Radhakrishnan.  Synlett, 2018, 29(15), 2023-2026.
  • Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines. P. R. Nitha, Manu M. Joseph, Greeshma Gopalan, K. K. Maiti, K. V. Radhakrishnan and Parthasarathi Das. Biomol. Chem. 2018, 16, 6430-6437.
  • Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair. Prabha B. Jayamurthy P, M Mahu, Neethu S, T. K. Manoj Kumar, Ananthakrishnan R, Rameshkumar K. B, Lekshmy Krishnan S, Sherin D. R. Bioorg. Med. Chem. 2018, 26(12), 3461-3467.
  • Dihydro-beta-agarofuran sesquiterpenoids from the seeds of Celastrus paniculatus Willd.  and their alpha-glucosidase inhibitory activity. P. Sasikumar , P. Sharathna , B. Prabha, Sunil Varughese, N. Anil Kumar, V. V. Sivan, D. R. Sherin, E. Suresh, T. K. Manojkumar  K. V. Radhakrishnan. Phytochem. Lett. 2018, 26, 1-8.
  • Lewis acid catalyzed Povarov reaction of pentafulvenes and spiro[2,4]-hepta-[4,6]-diene: An efficient access to cyclopentene fused quinolines” Synth. Comm. 2018, 48 (7), 816-829.
  • Lewis acid catalyzed activation of zerumbone towards sesquiterpenoid derivatives: Sustainable utilization of abundant natural resources towards chemically diverse architectures. Dhanya, B. P., Gopalan, Greeshma, Sasikumar Parameswaran, Neethu S, Meenu M T, Sharathna P, John, Jubi, Sunil Varughese, Sabu. M, Dan Mathew, Kokkuvayil Vasu Radhakrishnan. Asian J. Org. Chem. 2018, 7, 471-476.
  • A facile access to trans-3-styryl-4-hydrazinocyclopentenes via palladium catalyzed ring opening of diazanorbornenes with (Z)-beta-bromostyrenes/2,3-dibromohydrocinnamic acids. S. Saranya, S. Sarath Chand, Greeshma Gopalan, V. Jijitha, K. V. Radhakrishnan. Synthesis2018, 50(01), 184-192.
  • Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest and Anti-migratory Effects in SW480 Colorectal Cancer Cells. Thomas Sithara, Bhandara Purayil Dhanya, Karthika Bahulayan Arun, Suresh Sini,  Mathew Dan,Kokkuvayil Vasu Radhakrishnan, Prakasan Nisha. J. Agric. Food Chem., 201866 (3), 602–612
  • Accessing highly functionalized cyclopentanoids via a cascade palladation approach: unprecedented benzylic C–H activation towards cyclopentenoindanes. P. V. Santhini, Smrithy A. S, Irfana Jesin C. P., Sunil Varughese,  Jubi John, K. V. Radhakrishnan, Chem. Commun., 2018, 54, 2982-2985
  • Generation of ?,?-difluorinated metal-pentadienyl species through lanthanide-mediated C-F activation. Tarun Kumar, Fabien Massicot, Dominique Harakat, Sylviane Chevreux, Agathe Martinez, Klaudia Bordolinska, Preethanuj Preethalayam, Radhakrishnan Kokkuvayil Vasu, Jean-Bernard Behr, Jean-Luc Vasse, Florian Jaros, Chemistry – A European Journal, DOI :10.1002/chem.201704322. Chemistry: A European Journal,I 2017, 223(65),16460-16465.
  • Effects of a new synthetic zerumbone pendant derivative (ZPD) on apoptosis induction and anti-migratory effects in human cervical cancer cells. J.Saranya, B. P. Dhanya, Gopalan Greeshma, K. V. Radhakrishnan, S. Priya. Chemico-Biological Interactions, 2017278, 32-39
  • Rhodium(III)-Catalyzed C-H Activation of O-Acetyl Ketoximes/N-Methoxybenzamides toward the Synthesis of Isoquinoline/Isoquinolone-Fused Bicycles. Ajesh Vijayan, Choorappulan Ummu Jumaila, and Kokkuvayil Vasu Radhakrishnan Asian J. Org. Chem20176, 1561-1565.
  • Synthesis and in vitro evaluation of zerumbone pendant derivatives:  potentcandidates for anti-diabetic and anti-proliferative activities. B. P. Dhanya, Greeshma Gopalan, T. R. Reshmitha, J. Saranya,  P. Sharathna, I. G. Shibi, P. Nisha  and  K. V. Radhakrishnan. New J. Chem., 2017,41, 6960-6964.
  • Lewis acid promoted Regioselective Double Hydro(hetero)arylation of 6,6’-dialkyl Substituted Pentafulvene : A Facile Approach to Bisindole Derivatives, Parameswaran Sasikumar, Bernad Prabha, Sarngadharan Sarath Chand, Maniyamma Aswathy, Murali Madhukrishnan,  Preethalayam Preethanuj, Eringathodi Suresh,  Florian Jaroschik,  and Kokkuvayil Vasu Radhakrishnan, Eur. J. Org. Chem20172017, 4469–4474
  • Palladium-Catalyzed Cross-Coupling of Aryl Iodides with Heterobicyclic Olefins:  Access to Hydroarylated and Heteroannulated Motifs, Chemistry Select, Ajesh Vijayan, C. P. Ummu Jumaila, T. V. Baiju and K. V. Radhakrishnan, Chemistry Select201725913-5916.
  • Synthesis, Characterization and Reactivity of Formal 20 Electron Zirconocene Pentafulvene Complexes. Florian Jaroschik, Manfred Penkhues, Bernard Bahlmann, Emmanuel Nicolas, Malte Fischer, Fabien Massicot, Agathe Martinez, Dominique Harakat, Marc Schmidtmann, Radhakrishnan Kokkuvayil Vasu, Jean-Luc Vasse, Rüdiger Beckhaus. Organometallics 201736, 2004-2013.
  • Novel glycoconjugated squaraine dyes for selective optical imaging of cancer cells.  M. Shimi, Vandana Sankar, M. K. Abdul Rahim, P. R. Nitha, Suresh Das, K. V. Radhakrishnan and K. G. RaghuChem. Commun. 2017, 53, 5433-5436.
  • Metal-free trans-aziridination of zerumbone: Synthesis and biological evaluation of aziridine derivatives of zerumbone. Greeshma Gopalan, B. P. Dhanya, J. Saranya,T. R. Reshmitha, T. V. Baiju, M. T. Meenu, Mangalam S. Nair, P. Nisha and K V. Radhakrishnan. Eur. J. Org. Chem. 20172017, 3072-3077.
  • Recent Advances in the Chemistry of Pentafulvenes. Preethanuj P, Syam   Krishnan K, Sreeja Thulasi, Sarath Chand S., Jomy Joseph, Vijay Nair, Florian Jaroschik and K. V. Radhakrishnan. Chem. Rev. 2017117, 3930-3989.
  • Lewis acid catalyzed three component (3+2) cycloaddition reaction using Pentafulvene as 2pi component: An easy way to construct pentaleno(1,2-b) indoles. P.Santhini, S. Sarath Chand, Jubi John, R. Luxmi Varma, Florian Jaroschik, K. Radhakrishnan, Synlett. 2017, 28, 951-956.
  • Sequential tandem transformations of functionalized diazanorbornenes: Facile strategy towards pentacyclic frameworks with multiple stereocenters. Preethanuj P, Jijitha V, Ajesh Vijayan, Jubi John, K. V. Radhakrishnan. Synthesis, 2017, 49, 1816-1833.
  • Ruthenium/Iridium-catalyzed C-2 activation of indoles with bicyclic olefins: An easy access to functionalized heterocyclic motifs. Aparna P. S, Ajesh Vijayan, Saran P. Raveendran, Suresh E, R. Luxmi Varma, K. V.   Radhakrishnan, Synlett. 201728, 572-576.
  • Pd-catalyzed oxidative annulation of enamides with diazabicyclic olefins: A rapid access to cyclopentene fused 2-pyrrolines”, Santhini P. V, Nimisha Girija, Jubi John, Suresh Eringathodi, R. Luxmi Varma, Radhakrishnan K. V. Chem. Commun2017, 53, 1848-1851.
  • Comparison of antidiabetic potential of (+) and (-)-hopeaphenol, a pair of enantiomers isolated from Ampelocissus indica (L.) and Vateria indica Linn., with respect to inhibition of digestive enzymes and induction of glucose uptake in L6 myotubes”, P. Sasikumar, B. Prabha, T. R Reshmitha, Sheeba Veluthoor, Pradeepkumar, K. R. Rohit, B. P Dhanya, V. V Sivan, M.M. Jithin, N. Anil   Kumar, P. Nisha and K. V. Radhakrishnan, RSC Adv. 20166, 77075-77082
  • Phytochemical studies of an endemic and critically endangered hill banana, Musa acuminata Colla (AA) ‘Karivazhai’ fruit by GC-MS.  Sreejith, P. E, Linu, N. K, Sasikumar P, Radhakrishnan K. V, M. Sabu. J. Chem. Pharm. Res. 20168,164-168.
  • Guanidinium rich dendron-appended hydnocarpin exhibits superior anti-neoplastic effects through caspase mediated apoptosis, Bincy Mariyam Mathai,  Manu M. Joseph,   Santhi Maniganda,   Jyothi B. Nair,   J. S. Arya,   Varsha Karunakaran,  K. V. Radhakrishnan and    Kaustabh Kumar Maiti . RSC Adv.20166, 52772-52780
  • An easy access to fused chromanones via rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins, Ajesh Vijayan, T. V. Baiju, E. Jijy, Praveen Prakash, M. Shimi, Nayana Joseph, Petri M. Pihko, Sunil Varughese, K. V. Radhakrishnan. Tetrahedron, 2016, 72, 4007- 4015
  • Transition metal free intramolecular approach for the synthesis of cyclopenta[b]chromene derivatives from phenol substituted fulvene derived azabicyclic olefins, Ajesh Vijayan, T. V. Baiju, Sunil Varughese, K. V. Radhakrishnan. Tetrahedron Letters, 2016, 57, 2965–2968
  • Lewis Acid Catalyzed Regioselective Hydroheteroarylation of Pentafulvenes,  S. Sarath Chand, Greeshma Gopalan, P. V. Santhini, P. Preethanuj, Jubi John, Dominique Harakat, Florian Jaroschik, and K. V. Radhakrishnan. Org. Lett.201618, 964.
  • Titanium and zirconium hydride-catalyzed regioselective isomerization of 1,4-dihydrofulvenes: Access to 1-substituted 1,2-dihydrofulvenes.  Jomy Joseph, Preethanuj Preethalayam, K. V. Radhakrishnan, Florian Jaroschik, and Jean-Luc Vasse.  Org. Lett., 201517, 6202.
  • Lewis acid catalyzed C-3 alkylidenecyclopentenylation of indoles: An easy access to functionalized indoles and bisindoles. S. Sarath Chand, B. S. Sasidhar, Praveen Prakash, P. Sasikumar, P. Preethanuj, Florian Jaroschik, Dominique Harakat, Jean-Luc Vasse, K. V. Radhakrishnan. RSC Adv. 20155, 38075.
  • Studies on alpha-glucosidase, aldose reductase and glycation inhibitory properties of sesquiterpenes and flavonoids of Zingiber zerumbet Smith. K. R. Ajish, K. A. Antu, M. P. Riya, M. R. Preetharani, K. G. Raghu, B. P. Dhanya, K. V. Radhakrishnan. Nat Prod Res. 201529, 947.
  • Palladium catalyzed ring opening of cyclopropane appended spirotricyclic olefins with soft nucleophiles and organoboronic acids: Facile synthesis of functionalized spiro[2.4]heptenes.  Eliyan Jijy, Praveen Prakash, Thekke Veettil Baiju, Manchery Shimi, Yoshinori Yamamoto, Eringathodi Suresh, Kokkuvayil Vasu Radhakrishnan. Synthesis201446, 2629
  • Palladium catalyzed interceptive decarboxylative addition of allyl carbonates with carbonyl group.  T. V. Baiju, Nayana Joseph, Jainu Ajit, Praveen Prakash, K. V. Radhakrishnan, Sunil Varughese, Yoshinori YamamotoSynlett, 201425, 1246.
  • Titanium-catalyzed hydroalumination of conjugated dienes: Access to fulvene-derived allylaluminium reagents and their diastereoselective reactions with carbonyl compounds, Jomy Joseph, Florian Jaroschik, Dominique Harakat, K. V. Radhakrishnan, Jean-Luc Vasse, Jan Szymoniak. Chem. Eur. J. 201418, 5433.
  • Trapping the Lewis acid generated transient species from Pentafulvene derived diazanorbornenes with ortho-functionalized aryl iodides and aliphatic alcohols. S. Sarath Chand, S. Saranya, P. Preethanuj, B. P. Dhanya, E. Jijy, Praveen Prakash, B. S. Sasidhar, Jan Szymoniak, P. V. Santhini, K. V. Radhakrishnan. Org. Biomol. Chem. 2014, 12, 3045.
  • Ruthenium catalyzed desymmetrization of diazabicyclic olefins to access heteroaryl substituted cyclopentenes through C-H activation of phenylazoles. P. S. Aparna, B. Prabha, Praveen Prakash, E. Jijy, R. Luxmi Varma, K. V. Radhakrishnan. Tet. Lett. 201455, 865.
  • Synthesis of novel zerumbone derivatives via regio and stereoselective palladium   catalyzed decarboxylative coupling reaction: A new class of alpha- glucosidase inhibitors. K. R. Ajish, B. P. Dhanya, Nayana Joseph, M. Priya Rani, K. G. Raghu, V. P. Vineetha, K. V. Radhakrishnan. Tet. Lett. 201455, 665.
  • Bis-functionalization of 1,3-dienes via 1,4-conjugate addition of amphiphilic bis-pi-allyl   and related palladium intermediates T. V. Baiju, Ajesh Vijayan, Nayana Joseph, Preethanuj Preethalayam, K. V. Radhakrishnan, E. Suresh, Yoshinori Yamamoto      Synlett, 201425, 359.
  • Rhodium(III) catalyzed synthesis of isoquinolone fused azabicycles through C-H  activation of N-pivaloyloxy benzamides” Praveen Prakash, E. Jijy, P. S. Aparna, S. Viji, K. V. Radhakrishnan. Tetrahedron Lett. 2014, 55,916.
  • Rhodium(III)-catalyzed C-H activation of phenylazoles toward  C-N bond cleavage of diazabicyclic olefins: A Facile Access to mono– and bis– cyclopentenyl functionalized aza-heteroaromatics. Praveen Prakash, P. S. Aparna, E. Jijy, P. V. Santhini, Sunil Varughese, K. V. Radhakrishnan. Synlett, 2014, 25, 275.
  • Rhodium(III)-catalyzed de-symmetrization of strained olefins through C-H activation of o-acetyl ketoximes: An efficient synthesis of trans-functionalized cyclopentenes and spiro[2.4] heptenes. E. Jijy, Praveen Prakash, M. Shimi,S. Saranya,   P.Preethanuj, Petri M. Pihko, Sunil Varughese, K. V. Radhakrishnan.  Tet. Lett. 201354, 7127.
  • Cycloaddition profile of Pentafulvenes with 3-oxidopyrylium betaines: Effect of solvent, temperature and base on periselectivity.  Jinesh M. Kuthanapillil, A. Nijamudheen, E. Suresh, Ayan Datta, K. V. Radhakrishnan. Tetrahedron2013, 69, 9751-9760.
  • Mild rhodium(I) catalyzed ring opening of cyclopropane appended spirotricyclic olefins   through C-H activation of arylboronic acids. Praveen Prakash, Jijy E, Shimi M, Aparna   P. S, Suresh E, Radhakrishnan K. V. RSC Advan. 2013, 3, 19933-19936.
  • Synthesis and biological evaluation of carbohydrate appended hydrazinocyclopentenes with potent glycation and alpha-glucosidase inhibition activities.  K. R. Ajish, Nayana Joseph, M. Priya Rani, K. G. Raghu, V. P. Vineetha, K. V. Radhakrishnan. Tet. Lett.  2013, 54, 5682-5685.
  • Synthesis of functionalized indanes via Palladium catalyzed carboannulation of diazabicyclic olefins with o-iodostyrenes. E. Jijy, Praveen Prakash, S. Saranya, K. V. Radhakrishnan.  Synthesis, 2013, 45, 2583-2592.
  • Rhodium catalyzed oxidative coupling of salicylaldehydes with azabicyclic olefins: a one pot strategy involving aldehyde C-H cleavage and ?-allyl chemistry towards the synthesis of fused ring chromanones. K. V. Radhakrishnan, E. Jijy, P. Prakash, M. Shimi, P. M. Pihko, Joseph. N, Chem. Commun201349, 7349.
  • Palladium/Lewis Acid Mediated Domino Reaction of Pentafulvene derived diazabicyclic olefins: Efficient access to spiropentacyclic motif with an indoline and pyrazolidine fused to cyclopentene. Sarath Chand S, Jijy E, Praveen Prakash, Jan Szymoniak, Preethanuj P, Dhanya B. P, Radhakrishnan, K.V, Org. Lett201315, 3338.
  • Palladium catalyzed skeletal rearrangement of spirotricyclic olefins: A facile one pot strategy for the synthesis of a novel motif with cyclopentene fused to benzofuran and pyrazolidine. P. Prakash, E. Jijy, P. Preethanuj, P. M. Pihko, S. Sarath Chand, K. V. Radhakrishnan. Chem. Eur. J. 2013, 19, 10473-10477.
  • Transition metal catalyzed regio and diastereoselective 1, 4-conjugate addition of zerumbone using boronic acids: A facile route towards novel zerumbone derivatives. K. R. Ajish, Nayana Joseph, K. V. Radhakrishnan. Synthesis2013, 45, 2316.
  • Pentafulvene-derived eta3-allyltitanocenes as intermediates for the stereoselective functionalization of 5-membered carbocycles. Jomy Joseph, Florian Jaroschik, K. V. Radhakrishnan, Jean-Luc Vasse, Jan Szymoniak, Chem. Commun, 2013, 49, 4549-4551.
  • An exclusive approach to 3, 4-disubstituted cyclopentenes and alkylidene cyclopentenes via palladium catalyzed ring opening of azabicyclic olefins with aryl halides. Nayana Joseph, Rani Rajan, Jubi John, N. V. Devika, S. Sarath Chand, Eringathodi Suresh, Petri. M.Pihko, K. V. Radhakrishnan. RSC Advan. 2013, 3, 7751-7757.
  • Palladium catalyzed reaction of ortho-functionalized aryl iodides with bicyclic hydrazines: Facile route towards heteroannulated cyclopentenes and azabicycles. Jubi John, Rani Rajan, Sarath Chand S. Praveen Prakash, M, Nayana Joseph, Eringathodi Suresh, K. V. Radhakrishnan, Tetrahedron2013, 69, 152-159.
  • Palladium catalyzed 1,8-conjugate addition to heptafulvene via bis-pi-allyl palladium complexes. Sholly Clair George, Sreeja Thulasi, S. Anas, K. V. Radhakrishnan, Yoshinori Yamamoto, Org. Lett. 2011, 13, 4984-4987.
  • Transition metal catalyzed carboannulation of diazabicyclic alkenes with ambiphilic bifunctional reagents: a facile route towards functionalized indanones and indanols. Nayana Joseph, Jubi John, Rani Rajan, Sreeja Thulasi, Anupa Mohan, E. Suresh, K.V. Radhakrishnan. Tetrahedron2011, 67, 4905-4913.
  • Expeditious synthesis of N-bridged heterocycles via dipolar cycloaddition of pentafulvenes with 3-oxidopyridinium betaines.  Kuthanapillil, J.M.Thulasi, S. Krishnan, K. SSuresh, ERadhakrishnan, K.VTetrahedron, 2011, 67,  1272-1280.
  • Palladium-catalyzed bis-functionalization of isatylidenes: A facile route towards spiro-indol-2-ones. George S. C, John, J, Anas S, John J, Yamamoto Y, Suresh E, Radhakrishnan K. V. Eur.  J. Org.  Chem. 2010, 28, 5489-5497.
  • Trapping the pi-allylpalladium intermediate from fulvene-derived azabicyclic olefin with soft nucleophiles.  Rani Rajan, Jubi John, Sreeja Thulasi, Nayana Joseph, K. V. Radhakrishnan, R. C. SawantSynthesis, 2010, 3649-3656.
  • Palladium-catalyzed ring opening of azabicyclic olefins with organoindium and gallium reagents: A facile access towards benzylated cyclopentenes. Jubi John, B. Adarsh, K. V. Radhakrishnan. Tetrahedron, 2010, 66, 1383-1388.
  • Desymmetrization of meso bicyclic hydrazines: An efficient strategy towards the synthesis of functionalized cyclopentenes. V. S.Sajisha, S. AnasJubi John, K. V. Radhakrishnan. Synlett, 2009, 18, 2885-2895
  • Palladium catalyzed tandem ring opening- ring closing reaction of diazabicyclic alkenes: A facile one pot strategy for cyclopentannulation of heterocycles.  Jubi John, U. Indu, E. Suresh and K. V. Radhakrishnan.  J. Am. Chem. Soc2009, 131, 5042-5043.
  • Facile synthesis of alkylidene cyclopentenes via palladium catalyzed ring opening of fulvene derived bicyclic hydrazines. S. Anas, V.S. Sajisha, Jubi John, Nayana Joseph, Sholly Clair George, K.V. Radhakrishnan. Tetrahedron2008, 9689-9697.
  • Stereocontrolled synthesis of novel spirocyclic oxa-bridged cyclooctanoids through sequential transformations of pentafulvenes. Syam Krishnan K, Jinesh M. K, John J, Suresh C. H, Suresh E, Radhakrishnan K. V. Synthesis2008, 13, 2134.
  • A facile synthesis of novel triazabicyclic molecules as potential bicyclic templates for pharmaceutical ligands by the ring opening metathesis-cross metathesis of triazatricyclo[3.2.1.02,6]-dec-8-ene-3,5-diones.  Anas S, Sarika C, Rajan R, Radhakrishnan K. V. Indian J.  Chem. Section B.2008, 1063.
  • Periselectivity in the cycloaddition reactions of Pentafulvenes with 3-oxidopyrylium betaines: Effect of substituent on the C-6 carbon.  Syam Krishnan K, Rajan R, Radhakrishnan K. V. Synthesis2008, 12, 1955-1959.
  • A simple and efficient strategy towards eleven membered carbocycles via novel synthetic transformations of pentafulvenes. Syam Krishnan K, Suresh E, Radhakrishnan V. Eur. J. Org. Chem. 2007, 5847.
  • Iodine assisted palladium catalyzed ring opening of bicyclic hydrazines with organoboronic acids: Stereoselective synthesis functionalized cyclopenetenes /alkylidene cyclopentenes. S. AnasJubi John, Rani Rajan, Joshni John, E. Suresh, K. V. Radhakrishnan, Org. Biomol. Chem20075, 4010 – 4019.
  • Palladium catalyzed ring opening of azabicyclic olefins with organoindium reagents: A simple, clean and efficient synthesis of functionalized cyclopentenes.  Jubi John, S. Anas, V. S. Sajisha, S. Viji,  K. V. Radhakrishnan. Tet. Lett. 2007, 48, 7225-7227.
  • Interplay of dual reactivity in the reaction of pentafulvenes with 1,2,4-triazoline-3,5-diones: Experimental and theoretical investigations.  Anas S, Syam Krishnan K, Sajisha S, Anju K. S, Radhakrishnan K. V, Suresh E, Suresh C. H. New J. Chem. 200731, 237.
  • “Ionic Liquid [bmim]PF6 Mediated Synthesis of 1,2-Orthoesters of Carbohydrates and the Glycosidation Reactions of 4-Pentenyl Orthoesters”, Anas, S.; Sajisha, V. S.;  Rani Rajan, R. Thirumalai Kumaran and Radhakrishnan, K. V. Bulletin ChemicalSociety of Japan, 200780, 484.
  • “Molecular Recognition in an Organic Host-Guest Complex: CH…O and CH…p   Interactions Completely Control the Crystal Packing and the Host-Guest Complexation”,Radhakrishnan, K. V.; Anas, S., Suresh, E.; Nobuaki Koga, and Cherumuttathu  H. SureshBulletin Chemical Society of Japan,200780, 553.
  • “Studies on the synthetic utility of [6+3] cycloadiition of pentafulvenes with 3-oxidopyrylium betaines: Efficient synthesis of fused ring cyclooctanoids.” Krishnan, K. S. Smitha, M. a; Suresh, E. b Radhakrishnan, K. V.Tetrahedron, 62, 2006, 12345-12360.
  • “Palladium/Lewis Acid Catalysed Desymmetrization of  Fulvene Derived Bicyclic Hydrazines: A Facile Synthesis of Substituted Alkylidene Cyclopentenes”, S. Anas, V. S. Sajisha, Smitha Mohanlal,  K. V. Radhakrishnan, Synlett2006, 15, 2399-2402.
  • “Iodine assisted modified Suzuki type reaction of bicyclic hydrazines: stereoselective synthesis of functionalized cyclopentenes.” Jubi John,  V. S. Sajisha, Smitha Mohanlal,  K. V. Radhakrishnan Chem.Commun., 2006,33, 3510-3512.
  • “Regioselective Synthesis of Novel 7-5-8 fused Oxabridged Tricyclic Molecules via Consecutive Dipolar Cycloaddition of Pentafulvenes with 3-Oxidopyrylium Betaines.” K. Syam Krishnan, E. Suresh, Saumini Mathew and K. V. Radhakrishnan  Synthesis2006, 11, 1811-1818.
  • “[6+3] Cycloaddition of Pentafulvenes with 3-Oxidopyrylium Betaine: A Novel  Methodology towards the Synthesis of 5-8 fused Oxabridged Cyclooctanoids” K. Syam Krishnan, V. S. Sajisha, S. Anas, C. H. Suresh, M. M. Bhadbhade, G. V. Bhosekarand K. V. Radhakrishnan, Tetrahedron2006, 5952-5961.
  • “Palladium(0)/Lewis acid catalyzed Reactions of Bicyclic Hydrazines with Organostannanes: A General Methodology for the Stereoselective synthesis of 3,4-Disubstituted cyclopentenes” V. S. Sajisha, K. V. Radhakrishnan AdvancedSynthesis and Catalysis,2006, 348, 924-930.
  • A Facile Synthesis of 3-Allyl-4-hydrazinocyclopentenes by the Palladium(0)/Lewis Acid Mediated Ring Opening of Bicyclic Hydrazines with Allyltributyltin and Allyltrimethylsilane”  V. S. Sajisha, Smitha Mohanlal, S. Anas, K. V. Radhakrishnan Tetrahedron, 2006, 3997-4002.
  • “A facile synthesis of 1,2-orthoesters of carbohydrates in Ionic Liquid, [bmim]PF6.” K. V.  Radhakrishnan,Sajisha, V. S.; Jessy Maria Chacko Synlett2005, 997.
  • “A facile [6+3] Cycloaddition of Fulvenes with 3-Oxidopyrylium betaine: A Novel Methodology for the Synthesis of fused Cyclooctanoid Natural Products.” K. V. Radhakrishnan, K. Syam Krishnan, M. M. Bhadbhade, G. V. Bhosekar, Tetrahedron Letters2005, 4785-4788.
  • “Palladium Catalyzed Reaction of Bicyclic Hydrazines with Allyl- and Arylstannanes in Ionic Liquid [bmim]PF6: A Facile Method for the Synthesis of Substituted Hydrazinocyclopentene Derivatives.” Synlett, 2005, 2273-2276.
  • “The Husigen Reaction of Azomethine ylides to Isatins: A     facile          synthesis of Spiro-oxindoles”, Nair, V., Mathai, S., Augustine, A., Viji, S., Radhakrishnan, K. V., Synthesis, 2004, 2617.
  • “Concerning Tishchenko-like side  products in oxidaion of hydroxymethyl to formyl groups”, Guo, Z., Padmakumar, R., Hollinsworth, R. I., Radhakrishnan, K. V., Nandakumar, M. V., Fraser-reid, B., Synlett, 20031067.
  • “Chemoselective 1,3-Dipolar Cycloaddition Reactions of Rh(II) generated isomünchnones with 1,4quinones: synthesis of novel azapolycycles”, Nair, V., Santhi V., Sheela, K. C.,Radhakrishnan, K. V., Rath, N. P  Synthesis, 2003, 10, 1559.
  • “Ytterbium triflate for specific activation of n-pentenyl orthoesters in the presence of acid sensitive functionalities” Jayaprakash, K. N, Radhakrishnan, K. V, Fraser-Reid, Bert., Tetrahedron Lett.,2002, 43, 6953.
  • “One pot/two donors/one diol  give one differentiated trisaccharide: powerful evidence for reciprocal donor-acceptor selectivity(RDAS)”,  Fraser-Reid, Bert, Lopez J. CristobalRadhakrishnan, K. V.; Nandakumar, M. V., Ana Gomez, Uriel, Clara.,  Chem. Comm., 2002, 2104.
  • “Reciprocal Donor Acceptor Selectivity (RDAS): A New concept for matching Donors with Acceptors”, Fraser-Reid, Bert, Lopez J. CristobalRadhakrishnan, K. V.; Mach, Mateuscz.;  Schleuter, Urs.;. Ana Gomez, Uriel, Clara., Can. J. Chem., 2002, 80, 1075.
  • “Evidence for efficient unpromoted regioselective reactions of vicinal and non-vicinal diols,” Fraser-Reid, B, Anilkumar G, Nair, L. G., Radhakrishnan, K. V., Lopez J. Cristobal, Ana Gomez, Uriel, Clara, Aust. J. Chem., 2002, 55, 123.
  • Unexpected role  of O-2 protecting groups  of glycosyl donors in mediating  Regioselective Glycosidation”Fraser-Reid, Bert, Lopez J. CristobalRadhakrishnan, K. V.; Mach, Mateuscz.;  Schleuter,  Urs.;. Ana Gomez, Uriel, Clara, J. Am.Chem.Soc.2002, 124, 3198.
  • “[4+2] cycloaddition  reactions of coumarin quinone methide with pentafulvenes: facile   synthesis of novel polycyclic pyran derivatives”, Nair, V.; Jayan, C. N.; Radhakrishnan, K. V.; Anilkumar, G.; Rath, N. P. Tetrahedron,2001, 57(27), 5807-5813.
  • “Palladium-catalyzed controlled carbopalladation of benzyne”, Yoshikawa Eiji;   Radhakrishnan, K. V.; Yamamoto Yoshinori. J. Am. Chem. Soc., 2000, 122, 7280-7286.
  • “Synthesis of 1,2-diallyl derivatives of benzyne via palladium catalyzed reaction of  arynes with bis-?-allyl palladium complex”, Yoshikawa, E.; Radhakrishnan, K. V.; Yamamoto, Y. Tetrahedron Lett., 2000, 41, 729.
  • “Novel heterocyclic construction via dipolar cycloadditions to 1,2-dicarbonyl compounds” Nair, V.; Sheela, K. C.; Radhakrishnan, K. V.; Vinod, A. U.; Nair, S. J.; Rajesh, C.; Treesa, P. M.J. Heterocyclic chemistry, 2000, 37(3), 659-668.
  • “Hetero Diels-Alder reactions of thiobenzoquinones with heterocyclic dienes’,Nair, V.;    Mathew, B.; Radhakrishnan, K. V.; Rath, N. PSynlett, 2000, 1, 61.
  • “Palladium Catalyzed co-trimerization of Benzyne with alkynes. A facile method for        the       synthesis of phenanthrene derivatives”, Radhakrishnan, K. V.; Yoshikawa, E.;   Yamamoto, Y. Tetrahedron Lett., 1999, 40, 7533.
  • “Hetero-Diels-Alder reaction of o-benoquinones with tetracyclone: an efficient  method   for the synthesis of benzodioxinone derivatives”, Nair, V.; Mathew, B.; Radhakrishnan, K. V.; Rath, N. P. Tetrahedron55, 1999, 11017.
  • “Novel Dipolar Cycloadditions to 1,2-dicarbonyl compounds”, Nair, V.; Radhakrishnan, K. V.; Sheela, K. CRes. Chem. Intermed1999, 25, 877.
  • 1,3-Dipolar cycloaddition reaction of Nitrile-N-oxides with 1,2-benzoquinones: Facile    formation of 1,3-dioxazoles.  Nair V, Radhakrishnan K. V.; Sheela K. C. Tetrahedron1999, 55, 14199.
  • Some recent developments in higher-order cycoadditions. Nair, V, Anilkumar G, Nandakumar M. V, Radhakrishnan K. V, Rajesh C. J. Indian Chem. Soc. 1998, 75, 6709.
  • Novel cycloadditions of o-quinones and related chemistry. Nair V, Kumar S, Gopinathan Anilkumar, Anilkumar G, Radhakrishnan K. V, Nair, J. S, Davis, M, Sheela, K. C, Mathew, B, Treesa, P. M, Vinod, A. U, Jaya, P, Sheeba, V. Thomas, AIndian Acad. Sci. (Chem. Sci), 1998, 110.
  • Novel 1,3-dipolar cycloaddition reaction of carbonyl ylide with o-quinones. Nair V, Sheela K. C, Radhakrishnan K. V, Rath N. P. Lett. 1998, 39, 5627.
  • Diels-Alder reactions of a 6-arenyl fulvene with dienes and dienophiles and related chemistry. Nair, V, Anilkumar, G.; Radhakrishnan, K. V, Sheela, K. C, Rath, N. P. Tetrahedron, 1997, 53, 17361-17372.
  • Cycloaddition reactions of 3-ethoxycarbonyl-2H-cyclohepta[b]furan-2-one with 6,6- dialkyl, cycloalkyl and diaryl penafulvenes. Nair V, Anilkumar G, Radhakrishnan K. V, Nandakumar M. V, Kumar S. Tetrahedron, 1997, 53, 15903-15910.
  • Diels-Alder reactions of a 6-arenyl fulvene participatingboth as a diene and dienophile. Nair V, Nair A. G, Radhakrishnan K. V, Nandakumar M. V, Rath, N. PSynlett, 1997, 767.
  • DMF as a formate anion equivalent: Formolysis of tosylates in aqueous DMF.  Suri, S. C.; Rodgers, S. L, Radhakrishnan, K. V, Nair, VSyn. Commun. 1996, 26(50), 1031.
  • Oxidative addition of 1,3-dicarbonyl compounds to alkenes mediated by cerium (IV) ammonium nitrate and manganese(III)acetate: a comparative study. Nair V, Mathew J, Radhakrishnan K. VChem. Soc. Perkin Trans. I. 1996, 1487
  • 1,3-Dipolar cycloaddition of nitrile-N-oxides with 3,5-di-tert-butyl-1,2-benzoquinone: Facile formation of spiro-1,3-dioxazole. Nair V, Radhakrishnan K. V, Nair A. G, Bhadbhade M. M. Lett. 1996, 37(31), 5623.
  • Mechanism of rearrangement of 1, 8, 9, 10, 11, 11-hexachloro-3a, 6a-dihydroxy-tricyclo[6.2.1.02,7]undec-4,9- diene with potassium-tert-butoxide. Suri S. C, Radhakrishnan K. V. Indian J. Chem. 1994, 33B,1070.

List of Patents:

  • “2H-Chromenes annelated at C.sub.5-C.sub.6 and methods of making and using thereof.” (USA, International), Filed on Aug4, 2009, International application No: PCT/US2009/004803, Suresh Das, Mangalam S. Nair, K. V. Radhakrishnan and Bruno Dufour. Pub. NO: 2010/0056810A Granted on July 10, 2012., Pub. No: WO/2010/027/418, Publication date: 11.03.2010,
  • “Isoprenyl natural scaffold against MDR S. aureus and its synergistic combinations with conventional drugs thereof.” Kokkuvayil Vasu Radhakrishnan, Murugan Thulasi Meenu, Sidharth Chopra, Grace Kaul, Manjulika Shukla. Patent file number: 202111015503 dated 31.03.2021.
  • “Synergistic composition of Malabaricone B and conventional antibiotics agent multidrug resistant – Staphylococcus aureus” Neethu S, Dr. K V. Radhakrishanan, Dr. Sidharth Chopra, Manjulika Shukla, Grace Kaul, Dr. Mathew Dan, Govind M. G. Patent file number:0171NF2020, Applied on 16th October 2020.
  • “A short and cost-effective synthetic route towards antiviral drug, Molnupiravir (EIDD-2801) from D-ribose.” Jubi John, K. V. Radhakrishnan, Ravi Shankar L., Shridevi D., Sharathna P., Nitha P. R., A. Ajayaghosh, Application No. 202111019499, Filed to IPO.
  • “A short and cost-effective route towards antiviral EIDD-1931 and its hydrate polymorphs.”  Jubi John, Sunil Varughese, , Priyadarshini Thoppe Sivakumar, Jagadeesh K, Akhil Krishnan R, K. V. Radhakrishnan A. Ajayaghosh. Submitted

Book Chapters:

  • “Compounds with two Carbon-Heteroatom Bonds. Product Class 28.2. Benzo-1,2-quinones”, Nair, V and Radhakrishnan, K. V. Science of Synthesis, Vol. 28, p-181-215, 2006. Houben-Weyl Methods of Molecular Transformations, Geroge Thieme Verlag, Stuttgart.
  • “Heterocycles via Pyrylium and Pyridinium Betaines”, K. V. Radhakrishnan, Topics in Heterocyclic Chemistry, Vol.13, Synthesis of Heterocycles via Cycloadditions, 2008, 71-98., Springer.
  • “Cu-Catalyzed Homocoupling Reactions”, Ganesh Chandra Nandi, S. Ravindra, C. P. Irfana Jesin, P. Sasikumar, and K. V. Radhakrishnan, Wiley-VCH book. Copper Catalysis in Organic Synthesis, First Edition, 2020, p51-72, Wiley-VCH Verlag GmbH & Co. KGaA.
  • “Cu-Catalyzed Carbonylation Reactions”, P. Sasikumar, T. S. Priyadarshini, Sanjay Varma, Ganesh Chandra Nandi and K. V. Radhakrishnan, Wiley-VCH book. Copper Catalysis in Organic Synthesis, First Edition, 2020, p261-278, Wiley-VCH Verlag GmbH & Co. KGaA
  • “Strain Release of Bicyclic/Tricyclic Olefins via C-H Functionalization Reactions.” Praveen Prakash, Ajesh Vijayan and K. V. Radhakrishnan, Wiley-VCH book.  A handbook for C-H Functionalization. Submitted.
  • “Chapter 6: Screening of Musa balbisiana (Musaceae) seeds for antidiabetic properties and isolation of apiforol, a potential antidiabetic lead/ Greeshma Gopalan, B. Prabha, Alfred Joe and K. V. Radhakrishnan. Asian Zingiberales: Resume & Prospects: M. Sabu commemoration volume. published by: M/s Bishen Singh Mahendra Pal Singh. 2019, Dehra Dun, India.
Alumni
Syam Dr. K. SYAMKRISHNAN (2003-2008)
Present position
Assistant Professor
Mannam Memorial NSS College
Kottiyam, Kollam
Email: krissyam[at]gmail.com
  • 2008-09. Post-doctoral fellow with Prof. Petri M. Pihko, University of Jyvaskyla, Finland
  • 2010. post-Doctoral fellow with Prof. Jan Szymoniak, University of Reims, France.
  • 2011-13. Post-doctoral fellow with Prof. Fredrik Almqvist, Umea University, Umea, Sweden
Sajisha Dr. SAJISHA V.S. (2004-2008)
Present position
Researcher,
Fukushima laboratory
Tokyo Institute of Technology, Japan
Email: sajishas[at]gmail.com
  • 2011-14. Kothari Postdoctoral Fellow with Prof. Uday Maitra, IISc, Bangalore.
  • 2009. Postdoctoral Fellow with Prof. Hidehiro Sakurai, Institute for Molecular Sciences, Okazaki, Japan
Anas Dr. S. ANAS. (2004-2008)
Present position
Assistant Professor, School of Chemical Sciences, Hon Director Advanced
Molecular Materials Research Centre
(AMMRC) M. G. University, Kottayam
Email: anastvr[at]gmail.com
  • 2011-13. Carl Trygger Post- doctoral fellow with Dr. Henrik, Ottosson, Uppsala University, Sweden.
  • 2008-09. Post-doctoral fellow with Prof. Henri B. Kagan, Laboratoire de Catalyse, Moléculaire, Université Paris, France.
Jubi Dr. JUBI JOHN (2005-2010)
Present position
Senior Scientist
CSIR-NIIST, Trivandrum
Email: jubi.john[at]gmail.com
  • 2013-15. Post-Doctoral Fellow with Prof. Dr. Wim Dehaen, KU Leuven, Belgium
  • 2011-12. Humboldt fellow with Prof. Dr. Henning Hopf, TU Braunschweig, Germany
  • 2010-11. Euro Talent Fellow with Dr. Eric Doris, CEA Saclay, France.
  • 2016-19 : Scientist Fellow (QHS) and Assistant Professor of AcSIR at Organic Chemistry Section, CSIR-NIIST
Rani Dr. RANI RAJAN (2006-2011)
Present position
Assistant Professor
SN College, Punalur
Email: rani308[at]gmail.com
Jinesh Dr. JINESH M. KUTHANAPILLIL (2006-2010)
Present position
Assistant Professor
S.B. College, Changanassery
Email: jineshmathewk[at]gmail.com
Sholly Dr. SHOLLY CLAIR GEORGE (2007-2011)
Present position
Assistant Professor
St. Mary’s College, Manarcaud, Kottayam
Email: shollyclair[at]gmail.com
Nayana Dr. NAYANA JOSEPH (2008-2013)
Present position
Assistant Professor
Assumption College, Changanacherry
Email: nayanajoseph[at]gmail.com
Praveen Dr. PRAVEEN PRAKASH (2009-2013)
Present position
Assistant Professor
S. N. College, Kollam
Email: praveen.niist[at]gmail.com
  • Enhanced Eurotalents Fellow, Dr. Eric Doris, CEA Saclay, France
Ajish Dr. AJISH K.R. (2009-2013)
Present position
Assistant Professor
C.M.S College, Kottayam
Email: ajishragh[at]gmail.com
Jijy Dr. JIJY E. (2009-2013)
Present position
Assistant Professor
M.E.S. College, Nedumkandam, Idukki
Email: jijy20[at]gmail.com
  • Enhanced Eurotalents Fellow, CEA Saclay, at with Fred Taran at CEA Saclay, France.
Sarath Dr. S. SARATH CHAND (2010-2015)
Present position
Post-Doctoral Research Fellow
Prof. Charles L. Liotta Research Group
School of Chemistry and Biochemistry
Georgia Institute of Technology 911
Atlantic Dr. Atlanta, Georgia-30332 (USA)
Email: sarathchands[at]gmail.com
Sinu Dr. SINU C. R. (2010-2015)
(Combined supervision with Dr. Vijay Nair)
Present position
Research Associate
University of Vermont, USA
Email: crs1111[at]gmail.com
Anu Dr. ANU JOSE (2010-2015)
(Combined supervision with Dr. Vijay Nair)
Present position
Assistant Professor
Providence College, Calicut
Email: anuejose8[at]gmail.com
Baiju Dr. BAIJU T. V. (2012-2016)
Present position
Assistant Professor (on contract)
Brennen College, Thalassery
Email: baijutkr[at]gmail.com
  • 2016-17. Senior Research Fellow, IIT- Bombay  
  • 2017-19. Senior Research Fellow, IIT- Bombay
Preethanuj Dr. PREETHANUJ PREETHALAYAM (2011-2017)
Present position
Post Doctoral Fellow
With Dr. Henrik, Ottosson, Uppsala University, Sweden
Assistant Professor (on contract)
Payyanur College, Payyanur
Email: preethanuj106[at]gmail.com
Ajesh Dr. AJESH VIJAYAN (2013-2018)
Present position
UG Coordinator
Assistant Professor, Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengalure-560029
Email: avnajesh[at]gmail.com
Saranya Dr. SARANYA S. (2013-2017)
Present position
Assistant Professor (Guest)
St. Michael’s College, Cherthala
Email: saranyasreyas[at]gmail.com
Shereema Dr. SHEREEMA R. M. (2012-2017)
(Combined supervision with Dr. T. Prasada Rao)
Present position
Assistant Professor (on contract)
Carmel College, Thrissur
Email: sherinashejeer[at]gmail.com
Shimi Dr. SHIMI M. (2012-2017)
(Combined supervision with Dr. Suresh Das)
Present position
Assistant Professor (on contract)
Brennen College, Thalassery
Email:- durga.manchery[at]gmail.com
  • 2016-17: Senoor Research Fellow, IIT Bombay
  • 2017-19: Post-Doc, IIT Bombay
Aparna Dr. APARNA P. S. (2012-2017)
(Combined supervision with Dr. Luxmi Varma)
Present position
Associate Scientist, Aragen Life Sciences, Hyderbad
Email: ps.aparna2[at]gmail.com
  • Assistant Professor (on contract) Department of Chemistry, University of Calicut, Calicut.
Santhini Dr. SANTHINI P. V. (2013-2018)
(Combined supervision with Dr. Luxmi Varma)
Present position
Post-Doctoral Fellow with Prof. Dr. Wim
Dehaen, KU Leuven, Belgium (2018 to till date)
Email: santhinipv[at]gmail.com
Dhanya Dr. DHANYA B.P. (2013-2018)
(Combined supervision with Dr. Mangalam S Nair)
Email: bp.dhanya[at]gmail.com
  • 2018-19: Assistant Professor. (Adhoc), Department of Chemistry, NIT Calicut.
  • Assistant Professor, Swami Anandatheertha campus, Kannur Uty
  • Assistant Professor (Guest), SN College, Kannur and Krishnanmenon Memorial Govt. Women’s College, Kannur
Greeshma Dr. GREESHMA GOPALAN (2013-19)
Present position
Research Scientist, Process Research and Development, Sai Life Sciences, Shamirpet, Telangana.
Email: greema4[at]gmail.com
  • 2019-21: Post Doc at Department of Medicinal Chemistry, Uppasala University, Sweden
Sasikumar Dr. SASIKUMAR P (2014-2019)
Present position
Faculty (On contract)
IIRBS, Mahatma Gandhi University, Kottayam.
Email: sashparameswaran[at]gmail.com
  • 2019-20: Research Associate-I at CSIR-NIIST
Prabha Dr. PRABHA B. (2014-2019)
Present position
Research Associate at CSIR-NIIST
Email: prabha.24687[at]gmail.com
Sharthna Dr. SHARATHNA P. (2015-2020)
Present position
Research Scientist, Process Research and Development, Sai Life Sciences, Shamirpet, Telangana.
Email: sharathnasivan[at]gmail.com
Meenu Dr. MEENU M. T (2016-2021)
Present position
Assistant Professor (Guest)
BCM College, Kottayam
Email: meenuthulasi00[at]gmail.com
Neethu Ms. NEETHU S. (2016-2021)
Senior Research Fellow
Ph.D Student (from January 2016)
Email: neethusiva90[at]gmail.com
Santhi Ms. SANTHI S. (2015-2021)
(Combined supervision with Dr. Luxmi Varma)
Senior Research Fellow
Ph.D Student (from January 2015)
Email: santhilakshmi52[at]gmail.com
Ganesh Dr. GANESH CHANDRA NANDI
Present position
Assistant Professor
Department of Chemistry
National Institute of Technology, Trichy.
Email: ganeshnandi[at]gmail.com
  • 2017-18: Inspire Faculty Fellow, CSIR-NIIST  Ph.D. (Chemistry; 2018
Jency Dr. JENCY MOHAN T.
Email: jencymohandas[at]gmail.com
  • 2019-20: Research Associate-I, CSIR-NIIST with Dr. K V Radhakrishnan
  • Ph.D. (Chemistry; 2018), University of Calicut
Farha Dr. FARHA A. K.
Present position
Post-Doctoral Research Fellow, Department of Food Science and Technology, Shanghai Jiao Tong University, Shanghai
Email: farha.ak[at]gmail.com
  • 2016-18: SERB-National Post-Doctoral Fellowship, School of Marine Science, Cochin University of Science and Technology, Kerala
  • 2015-16: Research Associate at CSIR-NIIST with Dr. K.V. Radhakrishnan
  • 2010-2015: Ph. D. in Biotechnology (Regional Cancer Centre, Thiruvananthapuram)
Jijitha Ms. JIJITHA VAILASSERY
Present position
Ph. D student, Taiwan International Graduate program- Sustainable Chemical Science and Technology, SSSUN Lab, Institute of Chemistry, Academia Sinica, Taipei, Taiwan
Email: jijithavailassery[at]gmail.com
  • 2015-16: Project Assistant at CSIR-NIIST with Dr. K.V. Radhakrishnan
  • 2017: Assistant Professor (Contract): Assabah Arts and Science College, Valayamkulam, Malapuram
Ummu Ms. UMMU JUMAILA C. P
Email: jumailacp91[at]gmail.com
  • 2016-17: Project Assistant at CSIR-NIIST with Dr. K V Radhakrishnan
Saranya J Ms. SARANYA J
Present position
Scientific Officer, Govt. Pathology Lab (R & D), Australia
Email: saran4u1988[at]gmail.com
  • 2016-18: Project Assistant at CSIR-NIIST with Dr. K V Radhakrishnan
Madhukrishnan Mr. MADHUKRISHNAN M
Present position
Junior Research Fellow with Dr. Kaustabh Kumar Maiti, CSIR-NIIST.
Email: madhumuralikrishnan08[at]gmail.com
  • 2016-18: Research Intern at CSIR-NIIST with Dr. K V Radhakrishnan
SyamK Mr. SYAM KRISHNAN
Email: syamkrishnanrk[at]gmail.com
  • 2019-20: Project Assistant Gr II with Dr. K V Radhakrishnan
Sanjay Mr. SANJAY VARMA S.
Present position
Project Associate with Dr. Ravi. S. Lankalapalli at CSIR-NIIST
Email: sanj.var[at]gmail.com
  • 2019-20: Project Assistant at CSIR-NIIST
Shihas Mr. SHIHAS AHAMAD
Present position
Senior Research Associate, Syngene International Limited, Hyderbad
Email: sanj.var[at]gmail.com
  • 2019-20: Project Assistant at CSIR-NIIST with Dr. K V Radhakrishnan
Remya Mrs. REMYA RAJ P.
Project Assistant
Diploma in Computer Engg.
Email: remyapaniist[at]gmail.com
Group

Students

Hridya Dr.Hridya V K 
Designation : Post-Doctoral Fellow
Email : vkhridya[at]gmail.com
Prabha

Dr.Prabha B 
Designation : Research Associate (CSIR)
Email : prabha.24687[at]gmail.com
Ph. D (Natural Product Chemistry: 2019), University of Kerala

Biji Ms. Biji M
Designation : Senior Research Fellow (CSIR)
Ph.D Student (from September 2017)
Email : bijimohanan91[at]gmail.com
Aswathy Ms. Aswathi M  
Designation : Senior Research Fellow (CSIR)
Ph.D Student (from January 2018)
Email : aswathyarun995[at]gmail.com

 

Alishan Mrs. Alisha Valsan C 
Designation : Senior Research Fellow (CSIR)
Ph.D Student (from August 2018)
Email : alishavalsan[at]gmail.com

 

Vimal Mr. Vimalkumar P S 
Designation : Senior Research Fellow (CSIR)
Ph.D Student (from January 2019)
Email : vimalknair18[at]gmail.com

 

Anuja Ms. Anuja Joseph G 
Designation : Senior Research Fellow (CSIR)
Ph.D Student (from January 2019)
Email : anujajosephg[at]gmail.com

 

Priyadarshini Ms. Priyadarshini S 
Designation : Project Assistant Gr II
Ph.D Student (from August 2020)
Email : priyasavi[at]gmail.com

 

Sangeeth Mr. Sangeeth K 
Designation : Project Associate
Email : sangeeth1080[at]gmail.com

 

Abhijith Mr. Abhijith M B 
Designation : Project Associate
Email : abhijithmb97[at]gmail.com

 

Projects

Ongoing projects

  1. Two work packages in mission mode project on “Immuno Modulatory Function of Nutritionals and Nutraceuticals for Health and Wellness”
    1. Biomarker based evaluation of processed Priyala (Buchanania lanzan Spreng. Syn. B.latifolia Roxb) seeds for immunomodulation, its efficacy and validation studies..Funding
    Agency: CSIR (Nutraceutical Mission)

    2. Role of Spices and Condiments in Neuroprotection and Immunomodulation: Studies towards Correlating Lower Case-Fatality Rates of Indian Population during COVID Pandemic. Funding Agency: CSIR (Nutraceutical Mission, Nodal Lab CDRI)
  2. GAP-139539: “Sustainable Utilization of Abundant Natural Resources: Synthetic Transformations of Zerumbone and Germacrone Towards Chemically Diverse Sesquiterpenoid Architectures” (Project Leader, Duration: November 2018 to October 2021. Sponsor: Department of Science and Technology, New Delhi)
  3. HCP 29: “Development of Processes for Active Pharmaceutical Ingredients towards COVID-19” (Team member, Sponsor: 2020).

Completed Projects

From DST/SERB

  1. “Design, Synthesis and Biological Studies of Neoglycoconjugates” (Project Leader, Duration: 2005-2008, Sponsor: Department of Science and Technology, New Delhi).
  2. “Palladium Catalyzed Controlled Carbopalladation of Heterobicyclic Olefins” (Project Leader, Duration: 2010-2013, Sponsor: Department of Science and Technology, New Delhi).
  3. “Transition Metal/Lewis Acid Mediated Reactions of Strained Diazanorbornenes and Carbonyl Compounds: Efficient Access to Biologically Relevant Scaffolds”. (Project Leader, Duration: 2014-2017, Sponsor: SERB/Department of Science and Technology, New Delhi).

International collaborations

  1. Indo-Finland Collaboration with Prof. Petri Pihko, University of Jyvaskyla, Finland (Indo-Finland Project on Green methods towards pharmaceutically important heterocycles and cyclopentanoids [2011-2014])
  2. Indo-French Collaboration with Prof. Jan Szymoniak, University of Reims, France on Zirconium and Titanium chemistry of Penta fulvenes (Indo-French Project [2011-2014])

Industrial Projects

  1. NIIST-Corning SAS project on “Development of Superior Photochromic Dyes: Phase-I, Phase-II, Phase-III, Phase-IV and Phase-V –2006-2011”.
  2. A sponsored project from SABIC Industries, Saudi Arabia on “Development of Photochromic Materials”SABIC Industries, Saudi Arabia.(2014-15)
  3. A sponsored project from Aasha Biohem, Calicut for “Developing methodology for Synthesizing cis-derivatives of Oxyresveratroles”, Aasha Biochem, Calicut
  4. A sponsored project from Bipha Ayurvedics for “Phytochemical Evaluation of Raw Materials and Products”, Bipha Ayurvedics
  5. A sponsored Project from Govt. Homoeopathic medical college, Trivandrum entitled” Phytochemical study of Tinospora cordifolia and its standardization in homoeopathic mother tinctures by HPLC using berberine.

CSIR funded projects

  1. “Development of Catalysis and Catalysts-Specialty Chemicals”-10th FYP-2003-2008
  2. “Functional Organic Materials for Energy Efficient Devices” -11th FYP-Supra project Team member, 2008- 2012
  3. CSC-0130: “Natural Products as Affordable Health Care through Natural Products” (NaPAHA) (Team member, 2012-17)
  4. CSC-0108: “Organic Reactions in Generating Innovative and Natural Scaffolds” (ORIGIN) (Project leader 2012-17)
  5. NWP-55: “Organic Light Emitting Diodes (OLED)” (Team member, 2012-17)
  6. CSC-0125: “Catalysts for Specially Chemicals” (CSC- Nodal Lab: NEIST, Jorhat)
  7. Diversity Oriented Synthesis of Novel Chemical Entities for Antibacterial Screening (CSIR-Open Source Drug discovery Project (HCP-0001)
  8. HCP021: “Innovative Processes and Technologies for Agrochemicals” (Project Leader, Duration: January 2019 – March 2020. Sponsor: CSIR)
Profile

1. Education

  • M.Sc. Chemistry: 1992, Calicut University, Kerala, India
  • Master of Human Resource Management (MHRM): 2016, University of Kerala, India.
  • Ph.D. (Synthetic Organic Chemistry): 1998, University of Kerala (Regional Research Laboratory (CSIR), Thiruvananthapuram-695019, Kerala, India. Thesis entitled “Novel Dipolar Cycloaddition Reactions of o-Benzoquinones and Related chemistry” Supervisor: Dr. G. Vijay Nair.

2. Research Experience

  • June 2002 to date: Scientist, Organic Chemistry Section, CSIR-National Institute of Interdisciplinary Science and Technology (CSIR-NIIST) formerly Regional Research Laboratory, Thiruvananthapuram-695019, Kerala, India
  • November 2000 to May 2002: Post-Doctoral Fellow, NPG Research Institute, 3540, 840 Main Campus Drive, Raleigh, NC-27606, USA. Research Director: Prof. (Dr.). Bert Fraser-Reid.
  • May 2000 to October 2000: Post-Doctoral Fellow, Molecumetics Institute, 2023 120th Avenue, Bellevue WA 98005-2199, USA. Project Director: (Dr.). Michael Kahn
  • January 2000 to April 2000: Post-Doctoral Research Associate, Organic Chemistry Division, Regional Research Laboratory (CSIR), Thiruvananthapuram, Kerala, India. Supervisor: Dr. G. Vijay Nair
  • November 1998 to October 1999: Post-Doctoral Fellow, Department of Chemistry, Tohoku University, Sendai, Japan. Supervisor: Prof. Yoshinori Yamamoto
  • May 1993 to November 1998: Research Fellow and Research Associate, Regional Research Laboratory (CSIR), Thiruvananthapuram -19, Kerala, India. Research Director: Dr. Vijay Nair
  • December 1991 to April 1993: Research Assistant, Department of Chemistry, Christ College, Irinjalakuda, Kerala, India.

3. Thesis Supervision and Guidance

Ph.Ds completed

  • Thirty (30) students completed Ph.D.
  • One (1) student completed M. Tech
  • One (1) student completed M. Phil
  • One Hundred and Nineteen (119) students completed their MSc/MD project work

Currently supervising

  • Six (6) ongoing PhD Students (3 Chemistry & 3 Biology students)
  • One Ph. D. (1) student Co-guide
  • Two (2) Project Fellows
  • Two (2) Research Associates/Post-Doctoral Fellows

4. Publications

  • Papers published/in press in peer-reviewed international/national journals136
  • Patents 05
  • Book Chapters 05
  • Published contributions to academic conferences 142

5. Academic conferences

Conducted three national symposium, two workshops and one training program

  1. National Symposium on “Celebrating Years of Harmony with Organic Chemistry (CYHOC-2017)” during December 15th, 2017 at Hotel Residency Towers, Thiruvananthapuram. (Prof. R. H. Sahasrabudhey Birth Centenary Symposium)
  2. National Symposium on “Celebrating 25 Years of Harmony with Organic Chemistry (CYHOC-2016)” during December 16-17, 2016 at Hotel Residency Towers, Thiruvananthapuram.
  3. National Symposium on “Transcending Frontiers in Organic Chemistry (TFOC 2014)”, during October 9-11, 2014, held at CSIR-NIIST, Thiruvananthapuram, jointly organized by CSIR-NIIST and Kerala State Council for Science, Technology and Environment (KSCSTE), Thiruvananthapuram, Kerala.
  4. “Frontiers in Organic Synthesis and Drug Discovery” during July 21-22, 2011 organized under Open-Source Drug Discovery Program, jointly by CSIR-NIIST and Academy of Chemistry Teachers (ACT), Kerala.
  5. “Advances in Organic Synthesis and its Application in Drug Discovery during March 1-2, 2012 organized under Open-Source Drug Discovery Program, Jointly by CSIR-NIIST and Academy of Chemistry Teachers (ACT), Kerala.
  6. One day training program on “Insilico analysis of organic molecules for druggability and anti-mtb acitivity on 29th June 2012 at CSIR-NIIST, Thiruvananthapuram.