Dr.Sasidhar B.S.

Dr.Sasidhar B.S.

Sasidhar B S received his M.Sc. degree in Organic Chemistry in the year 2006 from the Department of Chemistry, Gulbarga University, Gulbarga. He started his professional career in leading pharmaceutical R&D’s in India; where he worked as Junior Research Scientist at Ranbaxy Laboratories Ltd., Gurgaon, and Research Scientist at Jubilant Life Sciences Ltd., (Jubilant Generics Ltd.) Nanjanagud during 2006-2008. He was involved in process development of several generic drugs and in the synthesis of New Chemical Entities (NCE’s) for the drug discovery program. After the brief industrial experience, he moved to Department of Chemistry, Gulbarga University for his PhD and obtained his doctorate degree in 2012 under the guidance of Prof. Jayaprakash S Biradar for the thesis entitled “Synthesis of Novel Heterocycles of Biological Importance”. In 2012 (October) Dr. Sasidhar joined as Scientist at Chemical Sciences and Technology Division, CSIR-NIIST.

Dr. Sasidhar’s group is focused on the interdisciplinary aspects of chemistry with respect to medicinal and material properties. This includes methodology, target-oriented synthesis, medicinal chemistry, and phytochemistry. The focused activity of the group on fundamental aspects of organic and medicinal chemistry has led to the successful translational projects.

Professional Experience

Professional Experience

  • Principal Scientist, CSIR-NIIST, Trivandrum, India (October 2019- to date).
  • Senior Scientist, CSIR-NIIST, Trivandrum, India (October 2016- October 2019).
  • Scientist, CSIR-NIIST, Trivandrum, India (October 2012- October 2016).
  • Research Scientist, Scale up and Process R&D, Jubilant Life Sciences Ltd, Nanjanagud, India (2007-2008).
  • Ranbaxy Laboratories Ltd., Gurgaon, India (2006-2007).
Achievements & Awards

Awards & Fellowships

  • ISAS-Young Scientist Award-2022, from the Indian Society for Analytical Scientists
  • RSC Chemical Communications Emerging Investigator – 2021.
  • Elected as Fellow of Indian Chemical Society – 2020, from Indian Chemical Society, Kolkata.
  • CSIR-Young Scientist Award -2019, from Council of Scientific & Industrial Research (CSIR), Ministry of Science and Technology, Govt. of India.
  • Associate Fellow of Indian Academy Sciences – 2019, from Indian Academy Sciences (IASc), Bangalore.
  • Kerala State Young Scientist Award (KSYSA) – 2017.  From, Kerala State Council for Science, Technology & Environment (KSCSTE)
  • CSIR-Senior Research Fellow, 2010-2012.
  • UGC- Research Fellowship in Science for Meritorious Students (RFSMS) 2008-2010.
  • University Merit Fellowship for Research, 2007-2008.
  • Yong Scientist Award (Best Oral Presenter) – NACEAC-2009, University of Mysore, 2009
Patents & Publications

Patents

  • Process for the preparation of pyrylium salts, US20210087158A1; March 25th 2021.
  • An Improved Process for the Preparation of Nitazoxanide and Intermediates Thereof. 202111045217, October 5th 2021.
  • Pyrazole amide based compounds and uses against Breast Cancer thereof –202111052657, November 16th 2021.

Publications

2022

  • Multicomponent Synthesis of Spiro-dihydropyridine oxindoles via Cascade Spiro-cyclization of Knoevenagel /aza-Michael Adducts. Durugappa, Basavaraja; C S, Athira; V. D., Siddalingeswar; Thiruthi, Ashitha; Somappa Sasidhar, Journal of Organic Chemistry, 2022. https://doi.org/10.1021/acs.joc.2c01063
  • Ethylbenzene Hydroperoxide: An Efficient Oxidizing Agent for Diastereoselective Synthesis of Spiro-epoxy Oxindoles. Praveen Kumar Valmiki, Mohan Banyangala, Sunil Varughese and Sasidhar B Somappa. Tetrahedron Letters, 2022, 108, 154126.
  • Marine Based Natural Products: Exploring the Recent Developments in the Identification of Antimicrobial Agents. Sangeetha Mohan, Ajay Krishna, Sasidhar B Somappa. Chemistry and Biodiversity, 2022, e202200513.
    Special issue: Unlocking the Biomedical Potential of Marine Natural Products.
  • Cu(OAc)2 Catalyzed Aerobic Oxidative 2-Aryl-3-acylquinoline Synthesis via Aza-Michael Addition and Aldol Condensation of alpha,beta-Unsaturated ketones and 2-Aminobenzyl alcohols. Athira C S, Basavaraj D, Praveen K. Valmiki, Shridevi D, Sasidhar B. Somappa. Tetrahedron Letters, 2022, 104, 154043.
  • Recent Advances in the Transition Metal-Free Synthesis of Heterocycles from alpha, beta-Unsaturated Ketones. Kizhakkan Thiruthi Ashitha, Ajay Krishna M S, Basavaraja D and Sasidhar Balappa Somappa. Chem. Front., 2022, 9, 5306.
  • Comprehensive review on medicinal applications of coumarin-derived imine-metal complexes. Siddappa A Patil, Vishal Kandathil, Anjali S, Sasidhar B S, Max R Feldman, Alejandro Bugarin, Shivaputra Patil. Molecules, 2022, 27, 5220.
    Special issue: Biologically active heterocyclic compounds.
  • An Insight into the Recent Developments in Anti-infective Potential of Indole and Associated Hybrids. Basavarajaih M, Sasidhar B Somappa. Journal of Molecular Structure, 2022, 1261, 132808.
  • The Nano-Based Catalyst for the Synthesis of Benzimidazoles. Rangappa S. Keri, Vinayak Adimule, Pravin Kendrekar, B. S. Sasidhar. Topics in Catalysis, 2022, https://doi.org/10.1007/s11244-022-01562-0.
  • Pd/Fe3O4 supported on bio-waste derived cellulosic-carbon as a nanocatalyst for C–C coupling and electrocatalytic application. Vishal Kandathil, Akshay Moolakkil, Pranav Kulkarni, Alaap Kumizhi Veetil, Manjunatha Kempasiddaiah, Sasidhar Balappa Somappa, R. Geetha Balakrishna, Siddappa A. Patil. Front. Chem. Sci. Eng., 2022, https://doi.org/10.1007/s11705-022-2158-y.
  • Phosphorescent Iridium Molecular Materials as Chemosensors for Nitroaromatic Explosives: Recent Advances. Anjali S, Sasidhar B S and M L P Reddy. Comments on Inorganic Chemistry, 2022, https://doi.org/10.1080/02603594.2022.2090347
  • Antibacterial natural products from microbial and fungal sources: a decade of advances. Sangeetha Mohan, Ajay Krishna, Manasa Chandramouli, Rangappa S. Keri, Siddappa A. Patil, Srikantamurthy Ningaiah, Sasidhar B. Somappa. Molecular Diversity, 2022, https://doi.org/10.1007/s11030-022-10417-5.
  • Synthetic and Natural Coumarins as Potent Anticonvulsant Agents: A Review with Structure-Activity Relationship. Rangappa Keri, Srinivasa Budagumpi, Sasidhar B. S. J Clin Pharm Ther. 2022; 00:1–17.
  • Eco-friendly anticorrosive epoxy coating from Ixora leaf extract: A promising solution for steel protection in marine environment. Krishnapriya Karattu Veedu, Sangeetha Mohan, Sasidhar Balappa Somappa, Nishanth Karimbintherikkal Gopalan. Journal of Cleaner Production, 2022, 340, 130750.

2021

  • Base-enabled access to diastereoselective spirofuran oxindoles and ?-functionalized allenoates. Basavaraja D., Ajay Krishna M. S., Jagadeesh Krishnan, Athira C. S., Amrutha R. R., Eringathodi Suresh and Sasidhar B. Somappa. Commun., 2021, 57, 1746-1749.
  • Waste biomass-derived carbon-supported palladium-based catalyst for cross-coupling reactions and energy storage applications. Manjunatha Kempasiddaiah, K. A. Sree Raj, Vishal Kandathil, Ramesh B. Dateer, Sasidhar, C. V. Yelamaggad, Chandra Sekhar Rout, Siddappa A. Patil. Applied Surface Science, 2021, 570 (30), 151156.
  • Anti-hyperlipidemic Potential of Natural Product Based Labdane-pyrroles via Inhibition of Cholesterol and Triglycerides Synthesis. Renjitha Jalaja, Shyni G. Leela, Mangalam S. Nair, Raghu K. Gopalan, and Sasidhar B. Somappa. Bioorganic Chemistry, 2021, 108, 104664.
  • Zerumin A attenuates the inflammatory responses in LPS-stimulated H9c2 cardiomyoblasts. G. L. Shyni, J. Renjitha, Sasidhar B. Somappa, K. G. Raghu. Journal of Biochemical and Molecular Toxicology, 2021, 35, e22777.
  • Epoxyazadiradione induced apoptosis/anoikis in triple negative breast cancer cells MDA MB-231 by modulating diverse cellular effects. Lakshmi S, Renjitha J, B Sasidhar S, Sulochana Priya. Journal of Biochemical and Molecular Toxicology, 2021, 35,e22756
  • A Green and Sustainable Cellulosic-Carbon Shielded Pd-MNP Hybrid Material for Catalysis and Energy Storage Applications. Vishal Kandathil, Alaap Kumizhi Veetil, Abhinandan Patra, Akshay Moolakkil, Manjunatha Kempasiddaiah, Sasidhar Balappa Somappa, Chandra Sekhar Rout & Siddappa A. Patil. Journal of Nanostructure in Chemistry. 2021, org/10.1007/s40097-020-00375-5.
  • An efficient, multicomponent synthesis of aminoalkylnaphthols via Betti reaction using ZSM-5 as a recoverable and reusable catalyst. Rangappa S. Keri, Mahadeo Patil, Srinivasa Budagumpi, S. Sasidhar. Appl Organometal Chem. 2021, e6316. DOI: 10.1002/aoc.6316 .
  • Azadiradione-loaded liposomes with improved bioavailability and anticancer efficacy against triple negative breast cancer. Fardous F.El-Senduny, Miram Altouhamy, Gamal Zayed, Choudhary Harsha, Renjith Jalaja, Sasidhar Balappa Somappa, Mangalam S. Nair, Ajaikumar B. Kunnumakkara Fahd M. Alsharif, Farid A. Badria.Journal of Drug Delivery Science and Technology, 2021, 102665.
    https://doi.org/10.1016/j.jddst.2021.102665.
  • Palladium-catalyzed denitrogenative cross-coupling of aryl halides with arylhydrazines under mild reaction conditions. Manjunatha Kempasiddaiah, Vishal Kandathil, Ramesh B. Dateer, S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Transition Metal Chemistry. 2021, 46, 273–281.

2020

  • Advanced Glycation End-products (AGE) Trapping Agents: Design and Synthesis of Nature Inspired Indeno[2,1-c]pyridinones. Anaga Nair, D. Basavaraja, Billu Abraham, P Nisha, Sunil Varughese, Jayamurthy Purushothaman, Sasidhar B.Somappa. Bioorganic Chemistry, 2020, 105, 104375.
  • NHC-Pd complex heterogenized on graphene oxide for cross-coupling reactions and supercapacitor applications. Vishal Kandathil, Aisha Siddiqa, Abhinandan Patra, Bhakti Kulkarni, Manjunatha Kempasiddaiah, S. Sasidhar, Shivaputra A. Patil, Chandra Sekhar Rout, Siddappa A. Patil. Appl Organometal Chem. 2020, e5924.
  • Hexagonal boron nitride supported N-heterocyclic carbene-palladium(II): A new, efficient and recyclable heterogeneous catalyst for Suzuki-Miyaura cross-coupling reaction. Arnet Maria Antony, Vishal Kandathil, Manjunatha Kempasiddaiah, S. Sasidhar, Shivaputra A. Patil & Siddappa A. Patil. Catalysis Letters, 2020, https://doi.org/10.1007/s10562-020-03401-x.
  • Rapid Visual Detection of Amines by Pyrylium Salts for Food Spoilage Taggant.
    Basavaraja D, Dibyendu Dey, Varsha T L, Chettiyan Thodi F. Salfeena, Manas K. Panda, Sasidhar B. Somappa. ACS Appl. Bio Mater. 2020, 3, 772?778.
  • I2/TBHP Mediated Diastereoselective Synthesis of Spiroaziridines. Kizhakkan Thiruthi Ashitha, Puthiya Purayil Vinaya, Ajay Krishna, Deepthy Cheeran Vincent, Renjitha Jalaja, Sunil Varughese, Sasidhar Balappa Somappa. Biomol. Chem., 2020, 18, 1588.
  • Immobilizing biogenically synthesized palladium nanoparticles on cellulose support as a green and sustainable dip catalyst for cross-coupling reaction. Manjunatha Kempasiddaiah, Vishal Kandathil, Ramesh B. Dateer, S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Cellulose, 2020, 27, 3335–3357.
  • DNA as a Bioligand Supported on Magnetite for Grafting Palladium Nanoparticles for Cross-Coupling Reaction. Vishal Kandathil, Manjunatha Kempasiddaiah, Sanna Kotrappanavar Nataraj, Sasidhar Balappa Somappa, Siddappa A. Patil. Appl Organometal Chem. 2020, e5357.
  • Immobilized N-heterocyclic carbene-palladium(II) complex on graphene oxide as efficient and recyclable catalyst for Suzuki–Miyaura cross-coupling and reduction of nitroarenes. Vishal Kandathil, Bhakti Kulkarni, Aisha Siddiqa, Manjunatha Kempasiddaiah, Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Catalysis Letters, 2020, 150:384-403.

2019

  • Magnetite tethered mesoionic carbene?palladium (II): Anefficient and reusable nanomagnetic catalyst for Suzuki?Miyaura and Mizoroki?Heck cross?coupling reactions inaqueous medium. Manjunatha Kempasiddhaiah, Vishal Kandathil, Ramesh B. Dateer, Balappa Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Appl Organometal Chem. 2019, e4846.
  • From Agriculture Residue to Catalyst Support; A Green and Sustainable Cellulose-Based Dip Catalyst for C-C Coupling and Direct Arylation. Vishal Kandathil, Manjunatha Kempasiddaiah, Sasidhar B. S., Siddappa A. Patil. Carbohydrate Polymers. 2019, 223, 115060.

2018

  • Synthesis of symmetrical and unsymmetrical triarylpyrylium ions by inverse electron demand Diels-Alder reaction.  C. T. Fathimath Salfeena, Basavaraja, K. T. Ashitha, V. Praveen Kumar, Sunil Varughese, Cherumuttathu H. Suresh and  B. S. Sasidhar. Chemical Communications, 2018, 54, 12463-12466.
  • Synthesis of 1,2,4-Trisubstituted-(1H)–Imidazoles Through Cu(OTf)2/I2 Catalyzed C-C Bond Cleavage of Chalcones and Benzylamines. Fathimath Salfeena, Chettiyan Thodi; Jalaja, Renjitha; Davis, Rincy; Suresh, Eringathodi; Somappa Sasidhar. ACS Omega, 2018, 3 (7), 8074–8082
  • Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors.  Renjitha Jalaja, Shyni Gangadharan Leela, Praveen Kumar Valmiki, Chettiyan Thodi F Salfeena, Kizhakkan T Ashitha, Venkata Rao D Krishna Rao, Mangalam S Nair, Raghu Kozhiparambil Gopalan, and Sasidhar Balappa Somappa. ACS Med. Chem. Lett., 2018, 9 (7), 662–666.
  • Phytochemical composition of Caesalpinia crista extract as potential source for inhibiting cholinesterase and ?-amyloid aggregation: Significance to Alzheimer’s disease. Kolambe Rajappa Chethana, Balappa Somappa Sasidhar, Mahadeva Naika,  Rangappa Sangappa Keri. Asian Pacific Journal of Tropical Biomedicine, 2018, 8(10), 500-512.
  • Biological evaluation of indole appended triazolothiadiazepine conjugates as potent anticancer agents. Kizhakkan T. Ashitha , Chettiyan T.F. Salfeena, Jalaja Renjitha, Valmiki P. Kumar, Rajesab Parveen, Balappa S. Sasidhar. Current Bioactive Compounds, 2018, 14 (4), 445-450.
  • Functionalized Pyrimidines from Alkynes and Nitriles: Application towards the Synthesis of Marine Natural Product Meridianin Analogs.  Banyangala Mohan, Chettiyan Thodi F. Salfeena, Kizhakkan T. Ashitha, Gopika V. Krishnan, Abdul Rasheed S. Jesmina, Angela M. Varghese, Siddappa A. Patil, Bhaskaran Nair S. Dileep Kumar, Balappa S. Sasidhar.  ChemistrySelect, 2018, 3, 6394 – 6398.
  • Green synthesis of palladium nanoparticles: Applications in aryl halide cyanation and Hiyama cross-coupling reaction under ligand free conditions.  Vishal Kandathil, Ramesh B. Dateer, B. S. Sasidhar, S. A. Patil, Siddappa A. Patil. Catalysis Letters, 2018, 148, 1562–1578.
  • Magnetic nanoparticle tethered Schiff base-palladium(II): highly active and reusable heterogeneous catalyst for Suzuki-Miyaura cross-coupling and reduction of nitroarenes in aqueous medium at room temperature. K. Manjunatha, Tuhin S. Kole, Vishal Kandathil, Ramesh B. Dateer, Geetha Balakrishna, B. S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil.   Appl Organometal Chem. 2018, 32, e4266.
  • An Uncommon Multicomponent Reaction Involving Nucleophilic Heterocyclic carbenes: Facile Synthesis of Fully Substituted Cyclopentanones.   Nair, Vijay; Krishnan, Jagadeesh; Jose, Anu; S, Sasidhar; Suresh, Eringathodi; S. Menon, Rajeev.  Organic Chemistry Frontiers, 2018, 5, 1202-1208.
  • A new magnetically recyclable heterogeneous palladium(II) as a green catalyst for Suzuki-Miyaura cross-coupling and reduction of nitroarenes in aqueous medium at room temperature.   Vishal Kandathil, Tuhin S. Koley, K. Manjunatha, Ramesh B. Dateer, Rangappa S. Keri,   B. S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil.   Inorganica Chimica Acta, 478 (2018) 195–210

2017

  • BF3•OEt2 Mediated Tandem Annulation: A Strategy to Construct Functionalized Chromeno-, and Pyrano- Fused Pyridines. Ashitha K. T,  Praveen Kumar V,  Fathimath Salfeena C. T,  B. S. Sasidhar. Journal of Organic Chemistry, 2018, 83, 113-124.
  • Epoxyazadiradione purified from the Azadirachtaindica seed induced mitochondrial apoptosis and inhibition of NF-B nuclear translocation in human cervical cancer cells. Shilpa G., Renjitha J., Saranga R., Sajin Francis K., Mangalam S. Nair, Beena Joy, B. S. Sasidhar and Priya S. Phytotherapy Research, 2017, 31, 1892–1902.
  • An overview of benzo [b] thiophene based medicinal chemistry. Rangappa S. Keri, Karam Chand, Srinivasa Budagumpi, B. S. Sasidhar, Siddappa A. Patil and Bhari Mallanna Nagaraj. European Journal of Medicinal Chemistry, 2017, 138, 1002-1033.
  • Biological evaluation of indole appended triazolothiadiazepine conjugates as potent anticancer agents. Kizhakkan T. Ashitha, C.T. Fathimath. Salfeena, Jalaja Renjitha, Valmiki P. Kumar, Rajesab Parveen and B. S. Sasidhar. Current Bioactive Compounds, 2017, DOI: 10.2174/1573407213666170707150757.
  • A Convenient, Efficient and Reusable N-Heterocyclic Carbene-Palladium(II) Based Catalyst Supported on Magnetite for Suzuki–Miyaura and Mizoroki–Heck Cross-Coupling Reactions. Siddappa A Patil, Vishal Kandathil, Bradley Fahlman, B. S. Sasidhar and S. Patil. New Journal of Chemistry, 2017, 41, 9531-9545.
  • Antibacterial and anti-tubercular evaluation of Dihydronaphthalenone-indole hybrid analogues. Praveen Kumar. V, Fathimath Salfeena. C.T, Ashitha. K.T, Sunil Varughese and B. S. Sasidhar. Chem Biol Drug Des, 2017, 90, 703-708.
  • Novel NHC-mediated synthesis of pyrrolo[2,1-a]isoquinolines and their photophysical investigations. Vijay Nair, Jagadeesh Krishnan, BalaramanVedhanarayanan, B. S. Sasidhar and Sunil Varughese. Chemistry-An Asian Journal, 2017, 12(6), 623–627.
  • Magnetic Nanoparticle-Supported N-Heterocyclic Carbene-Palladium (II): A Convenient, Efficient and Recyclable Catalyst for Suzuki-Miyaura Cross-Coupling Reactions. Vishal K, Bradley D. Fahlman, B. S. Sasidhar, S. A. Patil and Siddappa A. Patil. Catalysis Letters, 2017, 147,900–918.

2016

  • BF3•Et2O mediated one-step synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines. C. T. Fathimath Salfeena, K. T. Ashithaa, and B. S. Sasidhar. Organic & Biomolecular Chemistry, 2016, 14, 10165-10169.
  • Sequential NHC-Catalyzed Reaction of Enals and Cyclic Aryldiene-1,3-Diones: Synthesis of Tricyclic Chromenones and Related Compounds. Jagadeesh Krishnan, Sneha Mathew, P. Anjana Jayaprakash, B. S. Sasidhar, T. S. Mayadevi, E. Suresh and Vijay Nair. Asian Journal of Organic Chemistry, 2016, 5(12), 1447–1451.
  • Synthesis of novel Indolylbenzo[b][1,4] diazepins as a potent antimicrobial and antioxidant agents. J. S. Biradar and B. S. Sasidhar. Arabian J Chem, 2016, 9, S1063–S1068.

2015

  • Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents. Rangappa S. Keri, Siddappa A. Patil and B. S. Sasidhar. European Journal of Medicinal Chemistry, 2015, 100, 257-269.
  • Lewis Acid Catalyzed C-3 Alkylidene cyclopentenylation of Indoles: An Easy Access to Functionalized Indoles and Bisindoles. Sarath Chand S., B. S. Sasidhar, Praveen Prakash, Sasikumar P., Preethanuj P., Florian Jaroschik, Dominique Harakat, Jean-Luc Vasse and Radhakrishnan K. V. RSC advances, 2015, 5, 38075.
  • One-pot synthesis of indole appended heterocycles as potent anti-inflammatory, analgesic, and CNS depressant agents. B. S. Sasidhar, Jaiprakash SharnappaBiradar, ParveenRajesab, Shaik Rahber and MetySundar. Monatshefte fur Chemie, 2015, 146(12),2067–2078.

2014

  • Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho functionalized aryl iodides and aliphatic alcohols. S. Sarath Chand, S. Saranya, P. Preethanuj, B. P. Dhanya, E. Jijy, Praveen Prakash, B. S. Sasidhar, Jan Szymoniak, P. V. Santhini, and K. V. Radhakrishnan. Organic & Biomolecular Chemistry, 2014, 12(19), 3045-61.
  • Design and synthesis of novel thiopheno-4-thiazolidinylindoles as potent antioxidant and antimicrobial agents. Jaiprakash. S. Biradar, Rajesab Parveen and B. S. Sasidhar. Chemical Papers, 2014, 68 (3), 392–400.
  • Microwave assisted Synthesis of Novel Imidazolopyridinyl indoles as Potent Antioxidant and Antimicrobial Agents. Jaiprakash S. Biradar, Parveen Rajesab, and B. S. Sasidhar. Journal of Chemistry, 2014, Doi.org/10.1155/2014/579612.

2013

  • A Mini Library of Novel Indolyl triazolo thiadiazepines: Synthesis, Antioxidant and Antimicrobial Evaluations. Jaiprakash. S. Biradar, Rajesab Parveen, Naveen B. and B. S. Sasidhar. The Scientific World Journal, 2013, Doi.org/10.1155/2014/581737.
  • Synthesis of some bisindolyl analogs for in vitro cytotoxic and DNA cleavage studies. B. S. Sasidhar and J. S. Biradar. Med Chem Res, 2013, 22, 3518–3526.

2012- 2008

  • Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation. J. S. Biradar and B. S. Sasidhar. Eur J Med Chem, 2011, 46, 6112-6118.
  • Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives. J. S. Biradar, B. S. Sasidhar and R. Parveen. Eur J Med Chem, 2010, 45, 4074-4078.
  • Synthesis of new indolylbenzodiazepins and their DNA cleavage and antimicrobial activities. J. S. Biradar, R. Parveen, B. S. Sasidhar and S. M. Praveen. Ind J Het Chem, 2010, 20, 181-182.
  • A versatile one-pot synthesis of novel substituted pyrazoles, isaxazoles and their antimicrobial activity. J. S. Biradar, B. S. Sasidhar, S. M. Praveen and B. Sharanbasappa. Organic Chemistry, 2009, 5(3), 262-265.
  • Improved synthesis of some pyrazolines under microwave. J. S. Biradar, Praveen. S. Mugali, B. Sharanabasappa and B. S. Sasidhar. Ind J Het Chem, 2008, 18, 141-144.
  • One pot synthesis of substituted imidazoles containing indole and their antimicrobial activities. Jaiprakash. S. Biradar, Praveen. S. Mugali, B. S. Sasidhar and Parveen. Rajesab. Organic Chemistry, 2008, 4(6-8), 408-411.
  • Synthesis ofnovel 2, 5-disubstituted-3[3’-(pyridine-2”-yl)-1’-substituted pyrazole-5’-yl and isoxazol-5’-yl]-1H-indole in triethyl amine medium. J. S. Biradar, B. Sharanbasappa, S. M. Praveen and B. S. Sasidhar. Organic Chemistry, 2008, 4(4), 266-268.
Alumni
Fathima Dr. Fathimath Salfeena C. T.
(2014 to 2018)
Jagadeesh Dr. Jagadeesh Krishnan
(2014 to 2018)

 

Research Interest

Research Interest

Dr. Sasidhar’s group is focused on the interdisciplinary aspects of chemistry with respect to medicinal and material properties. This includes methodology, target-oriented synthesis, medicinal chemistry (Drug-like molecules), Green-chemistry, and phytochemistry. The focused activity of the group on fundamental aspects of organic and medicinal chemistry has led to the successful translational ...

Conference Presentations

Conference Presentations

  • Natural product derived triazole hybrids as potent pancreatic lipase inhibitors. Renjitha J and Sasidhar B. S, 32nd Kerala Science Congress, Yuvakshetra Institute of Management Studies, Mundoor, Palakkad, 25-27th January 2020.
  • I2/TBHP Mediated Diastereoselective Synthesis of Spiroaziridines.
    Ashitha K. T., Sasidhar B. S., 32nd Kerala Science Congress, Yuvakshetra Institute of Management Studies, Mundoor, Palakkad,  25-27th January 2020.
  • Nitriles: A Valuable Synthons in Nitrogen Containing-Heterocyclic and Building Block Synthesis. Ashitha K. T., Sasidhar B. S., CSIR- Inter Institutional Students Conference on Sustainable Chemistry for Heath, Environment and Materials (Su-CHEM Yuva 2019) at CSIR-Indian Institute of Chemical Technology, Hyderabad, during July 24th to 26th 2019.
  • Natural product derived triazole hybrids as potent pancreatic lipase inhibitors. Renjitha J, Shyni G. L, Raghu K. G and Sasidhar B. S, Current Trends in Drug Discovery Research (CTDDR-2019) at CSIR-CDRI, Lucknow, Uttar Pradesh, India. 20-23 February, 2019
  • Antibacterial evaluation of (E)-labda-8,(17),12-diene-15,16-dial isolated from the edible ginger Curcuma amada and its semisynthetic derivatives. Renjitha J, Dileep Kumar B. S and Sasidhar B. S, International seminar on Phytochemistry (ISP-2018) organized by Kerala academy of Sciences & Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, India. 26-27 March, 2018
  • BF3•OEt2 Mediated Tandem Annulation: A Strategy To Construct Functionalized Chromeno- and Pyrano-Fused Pyridines. Ashitha K.T. and Sasidhar B. S., XIV J-NOST Conference for Research Scholars organized at CSIR-Indian Institute of Chemical Technology, Hyderabad, during 28th November to 1st December, 2018.
  • Multicomponent strategy for the synthesis of N-substituted-1,2Dihydropyridines; Water acts as a reactant. Fathimath Salfeena C. T, Ashitha K. T, Sasidhar B. S., Poster presentation at CRSI NSC-21 National symposium, July 14-16, 2017, IICT-Hyderabad, India.
  • Isolation and synthetic modification of Bioactive from Nutraceutically important Curcuma amada.. J. Renjithaa, V. Praveen Kumar, Jubi Jacoba, Mangalam S. Nair, B. S. Dileep Kumar and B. S. Sasidhar., Poster presentation; at International Conference on Nutraceutical & Chronic Diseases, Sep 1-3, 2017, Goa, India.
  • Epoxy Azadiradione isolated from the Azadirachta Indica induced Mitochondrial mediated apoptosis in Hela cells. Shilpa G, Renjitha J, Sarang R, Sajin F, Mangalam S Nair, Sasidhar B S, Priya S, Oral Presentation; at International Conference on Nutraceutical & Chronic Diseases, Sep 9-11, 2016, Cochin, Kerala, India.
  • “Synthesis of Novel Substituted-3-imidazolyl indoles and their biological activities” Praveen. S. Mugali,Sharanabasappa B,Parveen R, Sasidhar. B. S. and J. S. Biradar*, at 26th Annualconference of Indian Council of Chemists, Department of Chemistry, Dr. H. S. Gour University, 25-27 December, 2007.
  • “Synthesis of novel diazepinylindoles and their Biological evaluation”,Parveen R, Praveen S. Mugali, Sharanabasappa B.Sasidhar. B. S. and J. S. Biradar*, at 26th Annual conference of Indian Council of Chemists, Department of Chemistry, Dr. H. S. Gour University, Sagar, 25-27 December, 2007.
  • “Synthesis of novel 2,5,- disubstituted-3[3’-(pyridine 2”-yl)-1’-substituted Pyrazol-5’-yl and isoxazol-5’-yl]-1H-indole in Triethylamine medium”,B.Sharanbasappa, Praveen.S.mugali andSasidhar. B.S and J.S.Biradar. At the International Conference on Drug Discovery and Nanotechnology, Department of Chemistry, YeshwantMahavidyalaya, Nanded, Maharashtra, India, January 27th -29th , 2008.
  • “One-pot synthesis of novel substituted pyrazoles and isaxazoles and their antimicrobial activity”, B. S. Sasidhar, Veena. R, Parveen. R., At Indian chemical societies 45th Annual Convention of Chemists and International Conference on Recent Advances in Chemistry, Department of studies in chemistry, Karnatak University, Dharwad, Karnataka, India, November 23-27, 2008.
  • “Synthesis and biological activities of 5-((e)-3-(2,5-disubstituted 1h-indol-3-yl)-(4- substituted phenyl) allylidene) pyrimidine 2,4,6(1h,3h,5h)-trione”B. S. Sasidhar, Parveen. R and J. S. Biradar, at the MEDCHEM 2009, Conference cum Workshop on Current Trends in Medicinal Chemistry, Department of Chemistry, Indisan Institute of Technology Madras, India, April 2-4, 2009.
  • “Synthesis and Biological Evaluation of Novel Substituted Pyrazoles, Isoxazoles and Pyrimidines”,B.S.Sasidhar, B. Sharanabasappa, Parveen R, & J. S. Biradar, at the NACEAC-2009, National Conference on the Emerging Areas in Chemistry. Department of Chemistry, University of Mysore, Mysore, Karnataka, India, on 31-07-2009 and 01-08-2009.
  • “Synthesis and Biological Activities of Some Novel Mannich Bases from Indole-3-carboxaldehydes”, B.S.Sasidhar, Sujatha.R& J. S. Biradar, at the NACEAC-2009, National Conference on the Emerging Areas in Chemistry. Department of Chemistry, University of Mysore, Mysore, Karnataka, India, on 31-07-2009 and 01-08-2009.
  • “Synthesis of Novel IndolylImidazoles and Their Biological Activities”Parveen R, B.S.Sasidhar,B. Sharanabasappa, & J. S. Biradar, at the ICCTCB-2009, Held at the Department of Chemistry, Central College Campus, Bangalore University, Bangalore, on 18-12-2009 and 19-12-2009, Bangalore, Karnataka, India.
  • “A one – pot, three components, solvent free, conventional and Microwave synthesis of novel indole analogues bearing 1H-pyrazol-5(4H)-one as a potent antioxidant agents”.B. S. Sasidhar and J. S. Biradar, at two days National Symposium on Frontier Areas in Chemical Science and Nanotechnology, held at Kuvempu University, during May 1-2, 2010.
  • “A conventional and Microwave synthesis of novel pyrimidinyl and thiazolidinyl indole analogues as a potent anticancer agents”B. S. Sasidhar, Parveen. Rand J. S. Biradar, in the Young Scientists Oral Presentation Category, at the 47th Annual Convention of Chemists – 2010 and International Conference on Recent Advances in Chemical Sciences, School of Studies in Chemistry, Pt. RavishankarShukla University, Raipur, Chattisgarh.
  • “A one-pot, three component, solvent- and catalyst-free Michael addition of indoles and their biological evaluation”B. S. Sasidhar, Parveen. R, S. Rahberand J. S. Biradar, in the Young Scientists Oral Presentation Category, at the ICSSC-2011, Department of Chemistry, Mangalore University, Mangalore, India, 08th-10th Dec-2011.
  • “A novel one pot synthesis of (2,5-dichlorothiophen-3-yl)-Pyrazol / Isoxazol / Pyrimidine Indole analogues as a potent Antioxidant and Anticancer agents” B. S. Sasidhar, Parveen. R, Rahaber. Sand J. S. Biradar, in the Young Scientists Oral Presentation Category (Organic Chemistry), at the 30th Annual Conference of Indian Council of Chemists, Department of Chemistry, Osmania University, Hyderabad,india, 28th-30th Dec-2011.
 
Projects

Projects

  • Development of mitochondrial antioxidants for geriatric well-being.
    CSIR Project; Co-Investigator- Ongoing
  • Trapping glycation intermediates for the modulation of diabetes and its complications: A natural product derived therapeutic approach.
    CSIR Project; Co-Investigator- Ongoing
  • Discovery & Pre-clinical Development of Antivirals for COVID-19 & other diseases.
    CSIR Project; Co-Investigator- Ongoing
  • Immuno modulatory function of nutritionals and nutraceuticals for health and wellness.
    CSIR Project; Co-Investigator- Ongoing
  • Base controlled diversity synthesis of spiro-indolinone hybrids of medicinal relevance.
    DST-SERB; Principal Investigator- Ongoing
  • Bio-stimulants for stress amelioration, enhanced plant productivity and soil health.
    CSIR Project; Co-Investigator- Ongoing
  • Sustainable utilization of regional biodiversity for the identification of value added chemical intermediates and phytopharmaceuticals.
    CSIR Project; Principal Investigator- Ongoing
  • Nature Inspired Chemical Entities for Healthcare Applications (NICE-HEALTH).
    DST-SERB; Principal Investigator- Ongoing
  • Development of commercially viable synthetic plant growth and soil fertility improvement compounds and its exploitation in agriculture.
    CSIR Project; Principal Investigator- Completed
  • Open Source Drug Discovery (OSDD).
    CSIR Project; Participating Scientist-Completed
  • CSIR-NIIST and SABIC industries collaborative project.
    Co-Investigator-Completed