Dr.Joshy Joseph

Dr.Joshy Joseph

Dr. Joshy Joseph is a Principal Scientist at CSIR-NIIST, Trivandrum & Associate Professor of AcSIR. He completed his Masters Degree in Chemistry from School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala in 1998 and Ph. D. from University of Kerala (work carried out at CSIR-NIIST, Trivandrum under the guidance of Dr. D. Ramaiah) in 2004. Subsequently, he worked as a Postdoctoral Fellow (2004-2006) and as a Research Scientist II (2006-2011) in Professor Gary B. Schuster’s group at School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, USA. In February 2012, he joined Chemical Science and Technology Division of CSIR-NIIST, Trivandrum as a Scientist. He is a recipient of prestigious Ramanujan Fellowship (2012) from DST, India and Raman Research Fellowship (2020) from CSIR, Govt of India. He is a life member of Chemical Research Society of India and Materials Research Society of India and a member of Royal Society of Chemistry. His current research interests include bio-molecular recognition, nucleic acid chemistry and design of functional organic materials.

http://www.niist.res.in/english/category/contact-us/J/directory
http://niist.irins.org/profile/64949
https://scholar.google.co.in/citations?user=W3GOD0wAAAAJ&hl=en
https://orcid.org/0000-0002-4592-8991

Professional Experience
  • Principal Scientist (February 2019 - to-date) at NIIST-CSIR, Trivandrum
  • Senior Scientist (February 2015 - February 2019) at NIIST-CSIR, Trivandrum
  • Scientist (February 2012 - February 2015) at NIIST-CSIR, Trivandrum
  • Ramanujan Fellow (October 2012 - September 2017) at CSIR-NIIST, Trivandrum
  • Research Scientist II (2006 - 2012) at School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA.
  • Postdoctoral Research Fellow (2004 - 2006) at School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA (Advisor: Professor Gary Schuster).
  • Senior Research Fellow (2002-2004) and Junior Research Fellow (2000-2002) under CSIR-NET Fellowship at NIIST-CSIR, Trivandrum (Advisor: Dr. D. Ramaiah).
  • JNCASR Research Fellow (1999-2000, 8 months) at NIIST-CSIR, Trivandrum (Advisor: Dr. D. Ramaiah).
  • M. Sc. Project Fellow (1998, 4 months) at the Photosciences and Photonics Division, National Institute for Interdisciplinary Science & Technology (NIIST-CSIR), Trivandrum.
Achievements & Awards

Awards & Fellowships

  • Raman Fellowship (CSIR, Govt of India; 2020-2021)
  • Ramanujan Fellowship (SERB, Govt of India; 2012)
  • CSIR Senior Research Fellowship (CSIR; 2002)
  • CSIR Junior research Fellowship (CSIR; 2000)
  • JNCASR Research Fellow (JNCASR, Bangalore; 1999)
Patents & Publications

Publications:

Google Scholar Profile:- http://scholar.google.co.in/citations?user=W3GOD0wAAAAJ
ORCID:- https://orcid.org/0000-0002-4592-8991

  • DNA condensation triggered by the synergistic self-assembly of tetraphenylethylene-viologen aggregates and CT-DNA, Saraswathi, S. K.; Karunakaran, V.; Maiti, K. K.; Joseph, J., Front. Chem., 2021, 9, 716771 (https://doi.org/10.3389/fchem.2021.716771)
  • Graphene quantum dots decorated with boron dipyrromethene dye derivatives for photodynamic therapy, Mangalath, S.; Saneesh Babu, P. S.; Nair, R. R.; Manu, P. M.; Krishna, S.; Nair, S. A.; Joseph, J., ACS Appl. Nano Mater., 2021, 4, 4162–4171. (https://doi.org/10.1021/acsanm.1c00486)
  • Chemical-free and scalable process for the fabrication of a uniform array of liquid-gated CNTFET, evaluated by KCl electrolyte, Agarwal, P. B.; Thakur, N. K.; Sharma, R.; Singh, P.; Joseph, J.; Tripura, C., Sci. Rep., 2021, 11, 3979. (https://doi.org/10.1038/s41598-021-83451-2)
  • A cross-linkable electron-transport layer based on a fullerene – benzoxazine derivative for inverted polymer solar cells, Vittala, S. K.; Ravi, R.; Deb, B.; Joseph, J., ChemPlusChem, 2020, 85, 1534-1541 (https://doi.org/10.1002/cplu.202000354)
  • Sequence programmed DNA three-way junctions for templated assembly of fluorescent silver nanoclusters, Saraswathi, S. K.; Vittala, S. K.; Manayani, M. K.; Joseph, J., J. Photochem. Photobiol. B, Biol., 2020, 207, 111886. (https://doi.org/10.1016/j.jphotobiol.2020.111886)
  • Nanosheets and 2D-nanonetworks by mutually assisted self-assembly of fullerene clusters and DNA three-way junctions, Vittala, S. K.; Saraswathi, S. K.; Ramesan, A. B.; Joseph, J., Nanoscale Adv., 2019, 1, 4158-4165. (http://dx.doi.org/10.1039/C9NA00485H)
  • A three-component supramolecular nanocomposite as a heavy-atom-free photosensitizer, Kumar, P. P. P.; Yadav, P.; Shanavas, A.; Thurakkal, S.; Joseph, J.; Neelakandan, P. P., Chem. Commun., 2019, 55, 5623-5626. (http://dx.doi.org/10.1039/C9CC02480H)
  • Novel Aza-BODIPY based turn on selective and sensitive probe for on-site visual detection of bivalent copper ions, Gawale, Y.; Mangalath, S.; Adarsh, N.; Joseph, J.; Ramaiah, D.; Sekar, N., Dyes Pigm., 2019, 107684. (https://doi.org/10.1016/j.dyepig.2019.107684)
  • Rational synthesis of a polymerizable fullerene–aniline derivative: study of photophysical, morphological and photovoltaic properties$$^{S }$$§, Vittala, S. K.; Ravi, R.; Deb, B.; Joseph, J., J. Chem. Sci., 2018, 130, 135. (https://doi.org/10.1007/s12039-018-1547-8)
  • Simple solution processable carbazole-oxadiazole hybrids for un-doped deep-blue OLEDs, Thurakkal, S.; Soman, A.; Unni, K. N. N.; Joseph, J.; Ramaiah, D., J. Photochem. Photobiol. A, 2018, 358, 192-200 (https://doi.org/10.1016/j.jphotochem.2018.03.012)
  • Design and synthesis of solution processable green fluorescent D-pi-A dyads for OLED applications, Thurakkal, S.; Sanju, K. S.; Soman, A.; Unni, K. N. N.; Joseph, J.; Ramaiah, D., New J. Chem., 2018, 42, 5456-5464. (https://doi.org/10.1039/C7NJ04386D)
  • Chiral self-assembly of fullerene clusters on CT-DNA templates, Kulala Vittala, S.; Joseph, J., Faraday Discuss., 2018, 207, 459-469. (https://doi.org/10.1039/C7FD00196G)
  • Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy, Gayathri, T.; Vijayalakshmi, A.; Mangalath, S.; Joseph, J.; Rao, N. M.; Singh, S. P., ACS Med. Chem. Lett., 2018, 9, 323-327. (https://doi.org/10.1021/acsmedchemlett.7b00490)
  • Fullerene Cluster Assisted Self-Assembly of Short DNA Strands into Semiconducting Nanowires, Vittala, S. K.; Saraswathi, S. K.; Joseph, J., Chem. Eur. J., 2017, 23, 15759-15765 (https://doi.org/10.1002/chem.201703333)
  • pH-Responsive Fluorescence Enhancement in Graphene Oxide-Naphthalimide Nanoconjugates: A Fluorescence Turn-On Sensor for Acetylcholine, Mangalath, S.; Abraham, S.; Joseph, J., Chem. Eur. J., 2017, 23, 11404-11409. (https://doi.org/10.1002/chem.201702198)
  • Carbazole-Linked Near-Infrared Aza-BODIPY Dyes as Triplet Sensitizers and Photoacoustic Contrast Agents for Deep-Tissue Imaging, Gawale, Y.; Adarsh, N.; Kalva, S. K.; Joseph, J.; Pramanik, M.; Ramaiah, D.; Sekar, N., Chem. Eur. J., 2017, 23, 6570-6578. (https://doi.org/10.1002/chem.201605702)
  • Transmissive-to-Black Electrochromic Devices Based on Cross-Linkable Tetraphenylethene-Diphenylamine Derivatives, Abraham, S.; Mangalath, S.; Sasikumar, D.; Joseph, J., Chem. Mater., 2017, 29, 9877-9881 (https://doi.org/10.1021/acs.chemmater.7b03319)
  • Tuning of photoluminescence properties of functional phthalides for OLED applications, Shanmugasundaram, M.; Joseph, J.; Ramaiah, D., J. Photochem. Photobiol. A, 2016, 330, 156-162 (http://dx.doi.org/10.1016/j.jphotochem.2016.08.008)
  • Selective recognition of cyanide ions by amphiphilic porphyrins in aqueous medium, Paul, A. K.; Karunakaran, S. C.; Jayaram, D. T.; Adarsh, N.; Joseph, J.; Ramaiah, D., J. Porphyr. Phthalocyanines, 2016, 20, 1368-1376. (https://doi.org/10.1142/s1088424616501133)
  • Simultaneous binding of a cyclophane and classical intercalators to DNA: observation of FRET-mediated white light emission, Sanju, K. S.; Thurakkal, S.; Neelakandan, P. P.; Joseph, J.; Ramaiah, D., Phys. Chem. Chem. Phys., 2015, 17, 13495-13500. (https://doi.org/10.1039/c5cp00208g)
  • Amino Acid-Porphyrin Conjugates: Synthesis and Study of their Photophysical and Metal Ion Recognition Properties, Paul, A. K.; Karunakaran, S. C.; Joseph, J.; Ramaiah, D., Photochem. Photobiol. 2015, 91, 1348-1355. (https://doi.org/10.1111/php.12527)
  • Cross-Linkable Fluorene-Diphenylamine Derivatives for Electrochromic Applications, Abraham, S.; Ganesh, G. P. T.; Varughese, S.; Deb, B.; Joseph, J., ACS Appl. Mater. Interfaces 2015, 7, 25424-25433 (https://doi.org/10.1021/acsami.5b08218)
  • Oxidative Thymine Mutation in DNA: Water-Wire-Mediated Proton-Coupled Electron Transfer, Barnett, R. N.; Joseph, J.; Landman, U.; Schuster, G. B., J. Am. Chem. Soc. 2013, 135, 3904-3914 (https://doi.org/10.1021/ja311282k)
  • Oxidatively generated damage to DNA at 5-methylcytosine mispairs, Joseph, J.; Schuster, G. B., Photochem. Photobiol. Sci. 2012, 11, 998-1003. (https://doi.org/10.1039/c2pp05379a)
  • One-electron oxidation of DNA: reaction at thymine, Joseph, J.; Schuster, G. B., Chem. Commun (Cambridge, U. K.) 2010, 46, 7872-7878. (https://doi.org/10.1039/C0CC02118K)
  • Oxidation of DNA: damage to nucleobases, Kanvah, S.; Joseph, J.; Schuster, G. B.; Barnett, R. N.; Cleveland, C. L.; Landman, U., Acc. Chem. Res. 2009, 43, 280-287. (https://doi.org//10.1021/ar900175a)
  • Oxidatively Damaged Nucleobases in Duplex DNA Oligomers: Reaction at Thymine? Thymine Mispairs, Joseph, J.; Schuster, G. B., J. Am. Chem. Soc. 2009, 131, 13904-13905 (https://doi.org//10.1021/ja9055917)
  • Long-distance radical cation hopping in DNA: the effect of thymine-Hg (II)-thymine base pairs, Joseph, J.; Schuster, G. B., Org. Lett. 2007, 9, 1843-1846. (https://doi.org/10.1021/ol070135a)
  • Steric effects on water accessability control sequence-selectivity of radical cation reactions in DNA, Cleveland, C. L.; Barnett, R. N.; Bongiorno, A.; Joseph, J.; Liu, C.; Schuster, G. B.; Landman, U., J. Am. Chem. Soc. 2007, 129, 8408-8409. (https://doi.org/10.1021/ja071893z)
  • Emergent functionality of nucleobase radical cations in duplex DNA: Prediction of reactivity using qualitative potential energy landscapes, Joseph, J.; Schuster, G. B., J. Am. Chem. Soc. 2006, 128, 6070-6074 (https://doi.org/10.1021/ja060655l)
  • Novel bifunctional viologen-linked pyrene conjugates: synthesis and study of their interactions with nucleosides and DNA, Hariharan, M.; Joseph, J.; Ramaiah, D., J. Phys. Chem. B 2006, 110, 24678-24686 (https://doi.org/10.1021/jp063079o)
  • Photoisomerisation of dibenzobarrelenes—a facile route to polycyclic synthons, Ramaiah, D.; Sajimon, M. C.; Joseph, J.; George, M. V., Chem. Soc. Rev. 2005, 34, 48-57. (https://doi.org/10.1039/b300843f)
  • Novel bifunctional acridine-acridinium conjugates: Synthesis and study of their chromophore-selective electron-transfer and DNA-binding properties, Kuruvilla, E.; Joseph, J.; Ramaiah, D., J. Phys. Chem. B 2005, 109, 21997-22002. (https://doi.org/10.1021/jp0543532)
  • Tuning of intercalation and electron-transfer processes between DNA and acridinium derivatives through steric effects, Joseph, J.; Kuruvilla, E.; Achuthan, A. T.; Ramaiah, D.; Schuster, G. B., Bioconjugate Chem. 2004, 15, 1230-1235. (https://doi.org/10.1021/bc0498222)
  • Design of Photoactivated DNA Oxidizing Agents: Synthesis and Study of Photophysical Properties and DNA Interactions of Novel Viologen Linked Acridines, Joseph, J.; Eldho, N. V.; Ramaiah, D., Chem. Eur. J. 2003, 9, 5926-5935. (https://doi.org/10.1002/chem.200304936)
  • Control of electron-transfer and DNA binding properties by the tolyl spacer group in viologen linked acridines, Joseph, J.; Eldho, N. V.; Ramaiah, D., J. Phys. Chem. B 2003, 107, 4444-4450 (https://doi.org/10.1021/jp027248q)
  • Steric and conformational effects on the photophysical and DNA binding properties of novel viologen linked tolylacridines, Eldho, N. V.; Joseph, J.; Ramaiah, D., Chem. Lett. 2001, 30, 438-439 (http://dx.doi.org/10.1246/cl.2001.438)

Patents awarded:

  • Viologen linked acridine based molecule and process for the preparation thereof,D. Ramaiah, N. V. Eldho, and J. Joseph, UK Patent No. 2378440B dated November 30, 2005
  • Viologen linked acridine based molecule and process for the preparation thereof,D. Ramaiah, N. V. Eldho and J. Joseph, US Patent No. 6630481 B2 dated Oct. 7, 2003.
  • A process for the preparation of viologen linked acridine based molecule use as phototherapeutical and catalytic photoactivated DNA cleaving agents,D. Ramaiah, N. V. Eldho and J. Joseph, CSIR# 368/2000 dated 27/2/2001(INDIA)
Alumni
  • Dr. Sreejith M.
    Awarded Ph. D. in 2018
    Current Position: Post-Doctoral Fellow at Georgia Institute of Technology, Atlanta
    E-mail: sreejithmangalath123[at]gmail.com
  • Dr. Sandeepa K. V.
    Awarded PhD in 2018
    Current Position: oLife Postdoctoral Fellow at Leiden University, Netherlands
    E-mail: kvsandeep89[at]gmail.com
  • Dr. Silja Abraham
    Awarded Ph. D. in 2017
    Current Position: Post-Doctoral Fellow at Georgia Institute of Technology, Atlanta, USA
    E-mail: zimlumariya[at]gmail.com
  • Mr. Mathews K. Manayani
    Joined as CSIR JRF in 2012
    Current Position: Assistant Proffesor in Nirmala College, Moovattupuzha
    E-mail: mathewsmanayani[at]gmail.com
Academic Qualification
  • Ph. D., Chemistry, 2004, CSIR-NIIST, Trivandrum (University of Kerala, Trivandrum)
    Thesis title: “Synthesis and study of photophysical and DNA binding properties of viologen linked acridine and acridinium derivatives”
    Thesis supervisor: Dr. D. Ramaiah, Photosciences and Photonics Division, CSIR-NIIST, Trivandrum
  • M. Sc. Organic Chemistry, 1999, School of Chemical Sciences, Mahatma Gandhi University, Kerala
    Thesis title: “Synthesis, photophysical and DNA binding studies of bisacridines”
    Thesis supervisor: Dr. D. Ramaiah, Photosciences and Photonics Division, CSIR-NIIST, Trivandrum
  • B. Sc. Chemistry, Physics and Mathematics, 1996, Mahatma Gandhi University, Kerala
Group
Anjali Anjali B. R
AcSIR PhD Student
UGC Senior Research Fellow
E-mail: anjalibeeyaar[at]gmail.com
Tel: 0471-2515249
Shibna Shibna Balakrishnan
AcSIR PhD Student
CSIR Senior Research Fellow
E-mail: shibnabal1993[at]gmail.com
Tel: 0471-2515249
Nishna Nishna N.
AcSIR PhD Student
UGC Senior Research Fellow
E-mail: nishnanish1085[at]gmail.com
Tel: 0471-2515249
Pavithra Pavithra V. Prabhu
AcSIR PhD Student
Project Associate - 1
E-mail: pavi.pavithravprabhu[at]gmail.com
Tel: 0471-2515249
Anagha Anagha Thomas
AcSIR PhD Student
INSPIRE Junior Research Fellow
E-mail: anaghathomas94[at]gmail.com
Tel: 0471-2515249
Sajena Dr. Sajena K.S.
Senior Project Associate
Awarded PhD in 2021
E-mail: sajenakanangat[at]gmail.com
Tel: 0471-2515249

 

Research Interest

Research Interest

Bio-organic chemistry - Nucleic acid chemistry, drug-DNA interactions, electron transfer in biological systems, small molecule based biosensors, self assembly on biological templates, cell-imaging.

Projects

Ongoing Projects

  • Development of mRNA Platform for Vaccines and Biotherapeutics – Multi-institutional Project (Project Leader – CSIR-NIIST; MLP-0064; Rs. 64 Lakhs)
    Duration: 2 Years (2021-2023)
    Sponsoring Agency: CSIR (Healthcare Theme – COVID-19)
  • Chromogenic Materials and Inks for Smart Coating and Printable Applications (Principal Investigator; MLP 0049; Rs.75 Lakhs)
    Duration: 3 Years (2020-2023)
    Sponsoring Agency: CSIR (Chemicals Theme – NCP)
  • Large area opto-electronics for Australia and India: From materials to advanced devices (Team Member; GAP-138839)
    Duration: 3 Years (2018-2021)
    Sponsoring Agency: DST (AISRF), Govt. of India Team Member
  • Translating Electrochromic Devices to 1’ × 1’ Dynamic Windows: Towards Industrial Smart Glass Technologies (Co-PI; MLP 0037)
    Duration: 1.5 Years (2020-2022)
    Sponsoring Agency: CSIR (Energy Theme – FTC)
  • Advanced Materials Mission- Development of Advanced Materials and Devices for Opto-electronic, Biomedical and Strategic applications (Team Member; HCP 0030)
    Duration: 3 Years (2020-2023)
    Sponsoring Agency: CSIR (Mission Project)

Completed Projects

  • COVID-19 ViralRNA detection kit with ultra-bright oligoprobes for the capture and detection of viralRNA via Lateral Flow based devices (Principal Investigator; MLP 0048; 39.00 Lakhs)
    Duration: 1 Year (2020-2021)
    Sponsoring Agency: CSIR (Healthcare Theme – COVID-19)
  • Development of novel NIR absorbing sensitizers and their nano-conjugates for the multimodal cancer imaging and therapy (Principal Investigator, GAP 137539; 20 Lakhs)
    Duration: 3 Years (2017-2020)
    Sponsoring Agency: DBT, Govt of India
  • New Materials for Improved, Cost-Effective Perovskite Solar Cells (Principal Investigator, GAP 136639; Rs.53.60 Lakhs)
    Duration: 3 Years (2015-2018)
    Funding Agency: DST – CERI
  • Chromogenic Materials for Smart Coating Applications (Principal Investigator, MLP 0030; Rs.134.012 Lakhs)
    Duration: 2 Years (2018-2020)
    Funding Agency: CSIR (Chemicals Theme, NCP)
  • Development of Cellular Sensors: Biocompatible fluorescent molecules for sensing and cellular imaging of pH, Zn2+ and reactive oxygen species (Principal Investigator, MLP 0027; Rs. 75 Lakhs)
    Duration: 1.5 Years (2018-2020)
    Funding Agency: CSIR (Healthcare Theme, FTT)
  • Electrochromic devices for efficient energy management and utilization (Co-PI, MLP 0022)
    Duration: 1.5 Years (2018-2020)
    Funding Agency: CSIR (Energy Theme, FTT)
  • Fused thiophene based FET devices for lung cancer VOC biomarker detection (Co-PI, MLP 0026; Rs. 50 Lakhs)
    Duration: 1.5 Years (2018-2020)
    Funding Agency: CSIR (Healthcare Theme, FTT)
  • Mission mode program ‘Nano-biosensors and microfluidics for healthcare’ (Principal Investigator & National Additional Coordinator; HCP-0012)
    Duration: 3 Years (2017-2020)
    Sponsoring Agency: CSIR (Healthcare Theme, Mission Mode Project)
  • Design and Synthesis of Multifunctional Organic-DNA Conjugates for Biomolecular Applications (Principal Investigator, GAP 133939; Rs. 54.15 Lakhs)
    Duration: 5 Years (2012-2017)
    Sponsoring Agency: SERB, Govt. of India (Ramanujan Fellowship Grant)
  • Synthesis and Development of Photochromic Materials (Co-PI, SSP 134939; US$ 1,72,804/-)
    Duration: 1 Year (2014-2015)
    Funding Agency: SABIC (Industry Sponsored Project)
  • Molecules to materials to devices for diagnostics – M2D (National Nodal Officer, CSC-0134; Rs. 831.45 Lakhs)
    Duration: 5 Years (2012-2017)
    Sponsoring Agency: CSIR (Chemical Cluster Mission Programme)
  • Dye Sensitized Solar Cells (DSSC)/Quantum Dot Dye Sensitized Solar Cells (Principal Investigator & Project leader; CLP 133739; Rs. 119.00 Lakhs)
    Duration: 4 Years (2012-2016)
    Sponsoring Agency: Ministry of New and Renewable Energy (MNRE), Govt. of India
  • Novel approaches for solar energy conversion under Technologies and Products for Solar energy Utilization through Networks (Team Member; TAP-SUN; NWP-54);
    Duration: 5 years (2011-2016)
    Sponsoring Agency: CSIR, India