Dr.Kaustabh Kumar Maiti

 Dr.Kaustabh Kumar Maiti

Kaustabh Kumar Maiti obtained a B.Sc. in Chemistry (Honours) and M.Sc. in organic chemistry (specialization) from the University of Calcutta (India) and was thereafter awarded a Ph.D. from the same university in the year 2001. His Ph.D. work is based on the development of synthetic methodologies of regio- and stereo-selective nitrogenous heterocycles by 1,3-dipolar nitrone cycloaddition with a wide variety of synthetic and naturally occurring diplorophiles.

Dr. Maiti started his professional career in leading pharmaceutical R&D in India, 2000-2003 (Alembic Ltd. and Sun Pharmaceuticals Industries Ltd.) where he worked in the process development of generic drugs and drug discovery programs. After industrial training, he joined postdoctoral research at Pohang University of Science and Technology (POSTECH, 2003-2007), South Korea, with Prof. Sung-Kee Chung in the Department of Chemistry and developed a series of novel non-peptide molecular transporters using inositol and carbohydrates as scaffolds.

Dr. Maiti moved to the Complex Carbohydrate Research Center (CCRC) at the University of Georgia, USA to continue his second postdoctoral research. In CCRC he worked with Prof. Geert-Jan Boons’s group (2007 -2009) in the field of glycopeptide, structural aspects of peptidoglycan, and LPS.
Before joining at CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Dr Maiti was appointed at Singapore Bioimaging Consortium (under Biomedical Sciences Institute, A*STAR, Singapore) as a Senior Researcher (2009-2012). He developed a series of Raman active molecules and surface-enhanced Raman scattering (SERS) nanoparticle probes as diagnostic tools for the detection and imaging of cancer cells and evaluated multiplex cancer biomarker detection in animal models.

His current research interest focuses on the development of diagnostics and Nano-theranostics (Nanomedicine) with multimodal combination therapy which includes chemotherapy, chemo-dynamic therapy, phototherapy (PTT, PDT), and immunotherapy for cancer and other non-communicable diseases including neurodegenerative disorders. In the diagnostic platform, one of the key techniques explored through Raman spectroscopy and its modified version i.e., surface-enhanced Raman spectroscopy (SERS) which has been widely implemented for ultrasensitive detection of a wide range of cancer biomarkers and aims to develop non-invasive-screening-modality-of-multiple-cancers through SERS and Artificial Intelligence (AI) platform for clinical translation. In biomedical applications, Dr. Maiti is keen to develop biocompatible nanoparticles (NPs) which are extensively investigated in disease diagnosis, targeted drug delivery systems, and bio-imaging.

In another area, Dr. Maiti is working in medicinal chemistry with a major focus on semi-synthetic modification of phytomolecules as a therapeutic lead. Aiming to generate advanced HITs towards anti-cancer profiling the group is working to generate a library of compounds through in vitro cell-based screening in order to generate Advanced HITs for the next level of pre-clinical and clinical studies.

Group Webpage: https://kkmweb.wixsite.com/kkmlabwebsite

Professional Experience

Professional and Postdoctoral Experience

  • Senior Principal Scientist
    April, 2020 - to date
    Chemical Science and Technology Division (CSTD)
    CSIR-National Institute for Interdisciplinary Science and Technology (NIIST),
    Council of Scientific and Industrial Research (CSIR), Govt. of India
    Thiruvananthapuram, India
  • Principal scientist
    April, 2015 - April, 2020
    Chemical Science and Technology Division (CSTD)
    CSIR-National Institute for Interdisciplinary Science and Technology (NIIST),
    Council of Scientific and Industrial Research (CSIR), Govt. of India
    Thiruvananthapuram, India
  • Senior Scientist
    April, 2012 - April, 2015
    Chemical Science and Technology Division (CSTD)
    CSIR-National Institute for Interdisciplinary Science and Technology (NIIST),
    Council of Scientific and Industrial Research (CSIR), Govt. of India
    Thiruvananthapuram, India
  • Research Scientist
    May, 2009 - March, 2012
    Biomedical Sciences Institutes (A*STAR)
    Singapore Bioimaging Consortium (SBIC), Biopolis, Singapore
  • Postdoctoral Research Associate
    May 2007 - March 2009
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA
  • Postdoctoral Research Scientist
    April 2003 - April, 2007
    Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang,
    South Korea
  • Executive, Discovery R&D
    Oct 2000 - March, 2003
    Sun Pharma Advanced Research Center (SPARC),
    Sun Pharmaceutical Industries Ltd., Vadodara, India
  • Research Officer, Chemical Research Division, Process-R&D
    Mar 2000 - Sep 2000
    Alembic Ltd., Vadodara, India
Achievements & Awards

Honors and Awards:

  • Service Excellence Award from Singapore Bioimaging Consortium (SBIC), A*STAR, Singapore, 2011
  • CSIR Technology Award, CSIR, Ministry of Science and Technology, Govt. of India, 2020

Professional Affiliations

  • Indian Chemical Society: Life Member
  • Chemical Research Society of India (CRSI): Life Member
  • Indian Science Congress Association (ISCA): Life Member
  • Indian Association for the Cultivation of Science (IACS) : Life Member
Patents & Publications

Publications and Patents

2023

  • Isolation of two new stereochemical variants of streptophenazine by cocultivation of Streptomyces NIIST-D31, Streptomyces NIIST-D47, and Streptomyces NIIST-D63 strains in 3C2 combinations; D. K. Induja, A. R. S. Jesmina, Manu M. Joseph, Shanmughan Shamjith, Nagaraja Ingaladal, Kaustabh Kumar Maiti, B. S. Dileep Kumar, Ravi S. Lankalapalli, The Journal of Antibiotics, DOI: https://doi.org/10.1038/s41429-023-00638-7 (Impact Factor: 3.424)
  • Cationic Donor-Two-Acceptor Dye-Graphene Quantum Dot Nanoconjugate for the Ratiometric Detection of Bisulfite Ions and Monitoring of SO2 Levels in Heat-Stressed Cells; Sharanabasava D. Hiremath, Ankit Thakuri, Manu M. Joseph, Akhil A. Bhosle, Kaustabh Kumar Maiti*, Mainak Banerjee*, and Amrita Chatterjee*; ACS Applied Nano Materials,DOI: https://doi.org/10.1021/acsanm.3c02043 (Impact Factor: 6.140)
  • Dual Mode ‘Turn-on’ Fluorescence-Raman (SERS) Response probe based on 1H-pyrrol-3(2H)-one scaffold for Monitoring H2S Levels in Biological Samples; Archana Panthalattu Parambil, Shanmughan Shamjith, Jais Kurian, Akila Kesavan, Ashis K. Sen, Paul R. Thangaraj, Kaustabh Kumar Maiti* and Muraleedharan K. Manheri*; Analytical Methods, DOI: 10.1039/D3AY00282A (Impact Factor: 3.532)
  • Detection of Sialic Acid and Imaging of Cell-Surface Glycan Using a Fluorescence-SERS Dual Probe; Palash Jana, Sudeep Koppayithodi, Madhukrishnan Murali, Monochura Saha, Kaustabh Kumar Maiti,* and Subhajit Bandyopadhyay*; ACS Sensors, DOI: https://doi.org/10.1021/acssensors.2c02849 (Impact Factor: 9.618)
  • Exploration of Phaeanthine: A Bisbenzylisoquinoline Alkaloid Induces Anticancer Effect in Cervical Cancer Cells Involving Mitochondria-Mediated Apoptosis; Alisha Valsan, Murugan Thulasi Meenu, Vishnu Priya Murali, Beutline Malgija, Anuja Gracy Joseph, Prakasan Nisha, Kokkuvayil Vasu Radhakrishnan,* and Kaustabh Kumar Maiti*; ACS Omega, https://doi.org/10.1021/acsomega.3c01023 (Impact Factor: 4.132)
  • Sortase E-mediated site-specific immobilization of green fluorescent protein and xylose dehydrogenase on gold nanoparticles; Ayilath Susmitha, Jayadev S. Arya, Lekshmi Sundar, Kaustabh Kumar Maiti, Kesavan Madhavan Nampoothiri*; Journal of Biotechnology, 367 (2023), 11-19 (Impact Factor: 3.595)
  • A clinically feasible diagnostic spectro-histology built on SERS-nanotags for multiplex detection and grading of breast cancer biomarkers; Vishnu Priya Murali, Varsha Karunakaran, Madhukrishnan Murali, Asha Lekshmi, Shamna Kottarathi, Selvakumar Deepik, Valliamma N. Sarith, Adukkadan N. Ramya, Kozhiparambil G. Raghu, Kunjuraman Sujathan*, Kaustabh Kumar Maiti*; Biosensors and Bioelectronics, 227 (2023), 115177 (Impact Factor: 12.54)
  • Monitoring glutathione dynamics in DNA replication (S-phase) using a two-photon reversible ratiometric fluorescent probe; Shayeri Biswas, Sourav Sarkar, Avinash Dhamija, Vishnu Priya Murali*, Kaustabh Kumar Maiti* and Sankarprasad Bhuniya* J. Mater. Chem. B, 2023,11, 1948-1957 (Impact Factor: 7.57)

2022

  • Targeted Delivery Polymeric Nanosystem Reinforced by Synergism of Embilin and RPI-1 for Therapeutics of Pancreatic Cancer; Jayadev S. Arya, Manu M. Joseph,* Vishnu Priya Murali, Murukan S. Vidyalekshmi, and Kaustabh Kumar Maiti*; ACS Appl. Nano Mater., (2022); 2022, 5, 12, 18622-18636 (Impact Factor: 6.14)
  • A non-invasive ultrasensitive diagnostic approach for COVID-19 infection using salivary label-free SERS fingerprinting and artificial intelligence; Varsha Karunakarana, Manu M.Josepha, InduprabhavYadev, HimanshuSharmac, K.Shamna, SumeetSaurav, Remanan Pushpa Sreejith, Veena Anand, Rosenara Beegum, S.Regi David, Thomas Iype, K.L.Sarada Devi, A.Nizarudheen, M.S.Sharmad, Rishi Sharma, Ravindra Mukhiya, Eshwar Thouti, Karuvath Yoosaf, Joshy Joseph, P.Sujatha Devi, S.Savithri, Ajay Agarwal, Sanjay Singh*, Kaustabh KumarMaiti*; Journal of Photochemistry and Photobiology B: Biology, (2022) 112545; 234 (2022), 112545 (Impact Factor: 6.814)
  • Elucidating cell surface glycan imbalance through SERS guided metabolic glycan labelling:An appraisal of metastatic potential in cancer cells; Madhukrishnan Murali, Vishnu Priya Murali, Manu M. Joseph, Soumya Rajan, Kaustabh Kumar Maiti*; Journal of Photochemistry and Photobiology B: Biology, Volume 234 (2022) 112506 (Impact Factor: 6.814)
  • Libocedroquinone: A Promising Anticancer Lead against Lung Cancer from Calocedrus Decurrens;Santhi Subramanya,Varsha Karunakaran,Selvakumar Deepika, Anuja Joseph Gracy, Veluthoor Sheeba, Karchesy Joseph, Kaustabh Kumar Maiti1, Ramavarma Luxmi Varma, Kokkuvayil Vasu Radhakrishnan*, Planta Medica International Open 2022; 9(1) 54-59 (Impact Factor: 3.007)
  • Porous polysaccharide scaffolds: Proof of concept study on wound healing and stem cell differentiation; Preethi Gopalakrishnan Usha, Sreekutty Jalajakumari, Unnikrishnan Babukuttan Sheela, Deepa Mohan, Archana Meena Gopalakrishnan, Maya Sreeranganathan, Raveendran Kuttan Pillai, Catherine Berry, Kaustabh Kumar Maiti, Sreelekha Therakathinal Thankappan*, Journal of Bioactive and Compatible Polymers 2022; 37 (2) 115-133 (Impact Factor: 2.13)
  • NADH-depletion triggered energy shutting with cyclometalated iridium (III) complex enabled bimodal Luminescence-SERS sensing and photodynamic therapy; Shanmughan Shamjith, Manu M. Joseph, Vishnu Priya Murali, Geetha S. Remya , Jyothi B. Nair, Cherumuttathu H. Suresh, Kaustabh Kumar Maiti*, Biosensors and Bioelectronics 204 (2022) 114087 (Impact Factor: 12.545)
  • An Efficient Molecular Luminophore based on Tetraphenylethylene (TPE) Enabling intracellular Detection and Therapeutic Benefits of Hydrogen Sulfide in Alzheimer’s Disease; Adukkadan N. Ramya, Manu M. Joseph, Varsha Karunakaran, Chekrain Valappil Shihas Ahammed, Animesh Samanta, Kaustabh K. Maiti* Sensors and Actuators B: Chemical 355 (2022), 131118 (Impact Factor: 9.221)

2021

  • Nanotheranostic Probe Built on Methylene Blue Loaded Cucurbituril [8] and Gold Nanorod: Targeted Phototherapy in Combination with SERS Imaging on Breast Cancer Cells; Nisha Narayanan, Jeong Hee Kim, Hema Santhakumar, Manu M. Joseph, Varsha Karunakaran, Shanmughan Shamjith, Giridharan Saranya, Palasseri T. Sujai, Ramapurath S. Jayasree,* Ishan Barman* and KaustabhKumarMaiti* J. Phys. Chem. B: 2021, 125, 49, 13415-13424 (Impact Factor: 3.466)
  • Dynamic self-assembly of mannosylated-calix[4]arene into micelles for the delivery of hydrophobic drugs; Padincharapad Sreedevi ,Jyothi B. Nair, Manu M. Joseph, Vishnu Priya Murali, Cherumuttathu H. Suresh, R. Luxmi Varma*, Kaustabh Kumar Maiti* Journal of Controlled Release 2021, 339, 284-296 (Impact Factor: 11.467)
  • De novo design and synthesis of boomerang-shaped molecules and their in silico and SERS-based interactions with SARS-CoV-2 spike protein and ACE2; Amrutham Linet, Manu M.Joseph, Mambatta Haritha, K. Shamna, Sunil Varughese, P. Sujatha Devi,* C. H. Suresh,* Kaustabh Kumar Maiti* and Ishita Neogi* New J. Chem. 2021, 45, 17777 - 17781 (Impact Factor: 3.925)
  • Elucidating Raman Image-Guided Differential Recognition of Clinically Confirmed Grades of Cervical Exfoliated Cells by Dual Biomarker-Appended SERS-Tag; Varsha Karunakaran, Valliamma N. Saritha, Adukkadan N. Ramya, Vishnu Priya Murali, Kozhiparambil G. Raghu, Kunjuraman Sujathan,* and Kaustabh Kumar Maiti*, Analytical Chemistry. 2021, 93, 32, 11140-11150, (Impact Factor: 8.008)
  • DNA Condensation Triggered by the Synergistic Self-Assembly of Tetraphenylethylene-Viologen Aggregates and CT-DNA; Sajena Kanangat Saraswathi, Varsha Karunakaran, Kaustabh Kumar Maiti and Joshy Joseph*, Frontiers in Chemistry, 2021, 9, 535-545. (Impact Factor: 5.545)
  • Mirabijalones S-W, rotenoids from rhizomes of white Mirabilis jalapa Linn. and their cell proliferative studies; P. Sharathna, V. Alisha, P. Sasikumar, Ajesh Vijayan, F. Ayisha, I.G. Shibi, V.V. Sivan, Kaustabh Kumar Maiti, Ravi S. Lankalapalli, K.V. Radhakrishnan*, Phytochemistry Letters, 44 (2021) 178-184. (Impact Factor: 1.873)
  • Phthalimide conjugation turns the AIE-active tetraphenylethylene unit non-emissive: its use in turn-on sensing of hydrazine in solution and the solid- and vapour-phase; Sharanabasava D. Hiremath, Ram U. Gawas, Dharmendra Das, Viraj G. Naik, Akhil A. Bhosle, Vishnu Priya Murali, Kaustabh Kumar Maiti, Raghunath Achary, Mainak Banerjee* and Amrita Chatterjee* RSC Adv., 2021, 11, 21269-21278. (Impact Factor: 4.036)
  • Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/ Photothermal Therapy; Kunnumpurathu Jibin, Marina Victor, Giridharan Saranya, Hema Santhakumar, VishnupriyaMurali, KaustabhK.Maiti and Ramapurath S. Jayasree* ACS Appl. Bio Mater. 2021, 4, 7, 5742-5752.
  • Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe; Santhi Subramanyan, Selvakumar Deepika, Anjitha Ajith, Anuja Joseph Gracy, Mathew Dan, Kaustabh Kumar Maiti1, Ramavarma Luxmi Varma, Kokkuvayil Vasu Radhakrishnan* Chem Biol Drug Des. 2021;00:1-6. (Impact Factor: 2.817)
  • Elucidating Gold−MnO2 Core−Shell Nanoenvelope for Real Time SERS-Guided Photothermal Therapy on Pancreatic Cancer Cells; Palasseri T. Sujai, Shanmughan Shamjith, Manu M. Joseph, and Kaustabh Kumar Maiti* ACS Appl. Bio Mater. 2021, 4, 6, 4962-4972
  • Raman Imaging: An Impending approach towards cancer diagnosise; Adukkadan N Ramya, Jayadev S Arya, Murali Madhukrishnan, Shanmughan Shamjith, Murukan S Vidyalakshmi, Kaustabh Kumar Maiti* Chem. An Asian Journal, 2021, 16, 409 -422 (Impact Factor: 4.839).
  • Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuation in cancer cell membrane; Arup Podder, Manu M Joseph, Shayeri Biswas, Sanjib Samanta, Kaustabh K. Maiti* and Sankarprasad Bhuniya * Chem. Commun., 2021,57, 607-610 (Impact Factor: 6.065).
  • A single benzene fluorescent probe for efficient formaldehyde sensing in living cells using glutathione as an amplifier; Anal Jana, Manu M.Joseph, Subrata Munan, Shamna K., Kaustabh Kumar Maiti* and Animesh Samanta;* Journal of photochemistry and photobiology B: Biology, 2021, 214, 112091 (Impact Factor: 6.814).

2020

  • Highly selective chemosensor for reactive carbonyl species based on simple 1,8-diaminonaphthalene; Anal Jana, Manu M. Joseph, Subrata Munan, Kaustabh Kumar Maiti*, Animesh Samanta;* Journal of photochemistry and photobiology B: Biology, 2020, 213, 112076 (Impact Factor: 6.813).
  • Biocompatible fluorescent probe for detecting mitochondrial alkaline phosphatase activity in live cells; Sabina Khatun, Shayeri Biswas, Arun Kumar Mahanta, Manu M. Joseph, Murukan S. Vidyalekshmi, Arup Podder, Pralay Maiti, Kaustabh Kumar Maiti, Sankarprasad Bhuniyaa*; Journal of Photochemistry & Photobiology, B: Biology, 2020, 212, 11204 (Impact Factor: 6.814).
  • Elucidating a Thermo-responsive Multimodal Photo-Chemotherapeutic Nano-delivery Vehicle to Overcome the Barriers of Doxorubicin Therapy ; Jyothi B Nair, Manu M Joseph*, Jayadev S Arya, Padincharapad Sreedevi, Palasseri T Sujai, and Kaustabh Kumar Maiti*; ACS Applied Materials and Interfaces, 2020, 12, 39, 43365-43379 (Impact Factor: 10.383).
  • NADH-Activated Dual Channel Fluorescent Probe for Multicolor Labeling of Live Cells and Tumor Mimic Spheroid; Arup Podder, Vishnu Priya Murali, Selvakumar Deepika, Avinash Dhamija, Shayeri Biswas, Kaustabh Kumar Maiti*, and Sankarprasad Bhuniya*; Analytical Chemistry , 2020, 92, 12356-12362 (Impact Factor: 8.008).
  • Tracking the Foot-prints of Paclitaxel Delivery and Mechanistic Action via SERS Trajectory in Glioblastoma Cells; Jyothi B Nair, Saswat Mohapatra, Manu M Joseph, Santhi Maniganda, Varsha Gupta, Surajit Ghosh, and Kaustabh Kumar Maiti* ACS Biomater. Sci. Eng., 2020, 6, 9, 5254-5263 (Impact Factor: 5.395).
  • Diagnostic Spectro-cytology revealing differential recognition of cervical Cancer lesions by label-free surface enhanced Raman fingerprints and Chemomssetrics; Varsha Karunakaran, Valliamma N. Saritha, Manu M.Joseph, Jyothi B. Nair, Giridharan Saranya, Kozhiparambil G. Raghu, Kunjuraman Sujathan*, Krishnan Nair S. Kumar*, Kaustabh K. Maiti* Nanomedicine: Nanotechnology, Biology and Medicine, 2020, 29, 102276 (Impact Factor: 6.458).
  • Targeted Theranostic Nano Vehicle Endorsed with Self-Destruction and Immunostimulatory Features to Circumvent Drug Resistance and Wipe-Out Tumor Reinitiating Cancer Stem Cells; Manu M. Joseph,* Adukkadan N. Ramya, Vineeth M. Vijayan, Jyothi B. Nair, Blossom T. Bastian, Raveendran K. Pillai, Sreelekha T. Therakathinal,* and Kaustabh K. Maiti* Small, 2020, 16, 2003309 (Impact Factor: 15.153).
  • A new pentacyclic pyrylium fluorescent probe that responds to pH imbalance during apoptosis; Sandip Chakraborty, Manu M Joseph, Sunil Varughese, Samrat Ghosh, Kaustabh Maiti, Animesh Samanta* and Ayyappanpillai Ajayaghosh* Chem. Sci., 2020, 11, 12695-12700 (Impact Factor: 9.969).
  • Self-assembled drug loaded glycosyl-protein metal nanoconstruct: Detailed synthetic procedure and therapeutic effect in solid tumor treatment; B.S. Unnikrishnana, S. Mayaa, G.U. Preethia, K.S. Anusreea, P.L. Reshmaa, M.G. Archanaa, Maiti Kumar Kaustabh, T.T. Sreelekhaa*; Colloids and Surfaces B: Biointerfaces 193 (2020) 111082 (Impact Factor: 5.999)
  • Reduced Graphene Oxide−Thioguanine Composites for the Selective Detection of Inorganic and Organic Mercury in Aqueous Media; Sharanabasava D. Hiremath, Kaustabh Kumar Maiti, Narendra Nath Ghosh, Mainak Banerjee*, Amrita Chatterjee*; ACS Applied Nano Materials 2020, 3, 3, 3071-3079 .(Impact Factor: 6.140).
  • Optically Controlled Hybrid Metamaterial of Plasmonic Spiky Gold Inbuilt Graphene Sheets for Bimodal Imaging Guided Multimodal Therapy; Kunnumpurathu Jibin, Jayaram S. Prasad, Giridharan Saranya, Sachin J. Shenoy, Kaustabh K. Maiti, Ramapurath S. Jayasree*; Biomater. Sci., 2020, 8, 3381-3391 (Impact Factor: 7.590)
  • Surface charge modulates the internalization vs penetration of gold nanoparticles: comprehensive scrutiny on monolayer cancer cells, multicellular spheroids and solid tumors by SERS modality; Palasseri T. Sujai, Manu M. Joseph,* Giridharan Saranya, Jyothi B. Nair, Vishnu Priya Murali and Kaustabh Kumar Maiti*; Nanoscale, 2020, 12, 6971-6975 (Impact Factor: 8.307).
  • Biogenic Ag Nanoparticles of Neem Extract; its Structural Evaluation and Antimicrobial Effects against Pseudomonas nitroreducens and Aspergillus unguis - NII 08123; Sarah B. Ulaeto, Gincy Marina Mathew, Jerin K Pancrecious, Jyothi B Nair, Thazhavilai Ponnu Devaraj Rajan*, Kaustabh Kumar Maiti, and B.C. Pai, ACS Biomater. Sci. Eng. 2020, 6, 1, 235-245 (Impact Factor: 5.935)

2019

  • Galactoxyloglucan-Modified Gold Nanocarrier of Doxorubicin for Treating Drug-Resistant Brain Tumors; Remya Komeri, Maya S, B. S. Unnikrishnan, J. Sreekutty, Preethi GU, Kaustabh Kumar Maiti, and Therakathinal T. Sreelekha* ACS Appl. Nano Mater. , 2019, 2, 6287-6299.
  • Exploring Mitochondria Mediated Intrinsic Apoptosis by New Phytochemical Entities: An Explicit Observation of Cytochrome c Dynamics on Lung and Melanoma Cancer Cells; Jayadev S Arya, Manu M Joseph*, Daisy Sherin, Jyothi B Nair, Thanathu Krishnan Manojkumar*, and Kaustabh Kumar Maiti* J. Med. Chem., 2019, 62, 8311-8329 (Impact Factor: 6.20)
  • NADH- Induced "kick-on" Fluorescent Probe Validates Cross talk with Redox Regulator GSH; Mrinmoy Maiti, Vishnu Priya Murali, Selvakumar Deepika, Arup Podder, Kaustabh Kumar Maiti,*and Sankarprasad Bhuniya* Sensors & Actuators: B. Chemical, 2019, 299, 126964 (Impact Factor: 7.10).
  • Curcuma raktakanda Induces Apoptosis and Suppresses Migration in Cancer Cells: Role of Reactive Oxygen Species; Shruti Mishra, Sumit Singh Verma, Vipin Rai, Nikee Awasthee, Jayadev S. Arya, Kaustabh Kumar Maiti, and Subash C. Gupta* Biomolecules, 2019, 9, 159 (Impact Factor: 4.08).
  • Bimodal Detection of Carbon Dioxide Using Fluorescent Molecular Aggregates; Rakesh K. Mishra, Samiyappan Vijayakumar, Arindam Mal, Varsha Karunakaran, Jith C. Janardhanan, Kaustabh Kumar Maiti, Vakayil K. Praveen and Ayyappanpillai Ajayaghosh* Chem. Commun., 2019, 55, 6046-6049 (Impact Factor: 5.99).
  • Endogenous H2S‐Assisted Cancer-Cell-Specific Activation of Theranostics with Emission Readout; Kondapa Naidu Bobba, Giridharan Saranya, Palasseri T. Sujai, Manu M. Joseph, Nithya Velusamy, Arup Podder, Kaustabh Kumar Maiti*, and Sankarprasad Bhuniya* ACS Applied Biomaterials, 2019, 2, 1322-1330.
  • Biogenic Cluster-Encased Gold Nanorods as a Targeted Three-in-One Theranostic Nanoenvelope for SERS-Guided Photochemotherapy against Metastatic Melanoma; Palasseri T. Sujai, Manu M. Joseph*, Varsha Karunakaran, Giridharan Saranya, Ramya N. Adukkadan, Shanmughan Shamjith, Reshmi Thomas, Jyothi B. Nair, Rotti Srinivasamurthy Swathi, and Kaustabh Kumar Maiti* ACS Applied Biomaterials, 2019, 2 (1), pp 588-60

2018

  • Enzyme-Driven Switchable Fluorescence-SERS Diagnostic Nanococktail for the Multiplex Detection of Lung Cancer Biomarkers; Giridharan Saranya,Manu M. Joseph, Varsha Karunakaran, Jyothi B. Nair, Valliamma N. Saritha, Vamadevan S. Veena, Kunjuraman Sujathan*, Ayyappanpillai Ajayaghosh*, and Kaustabh K. Maiti*, ACS Applied Materials and Interfaces, 2018, 10 (45), pp 38807-38818 (Impact Factor: 8.75).
  • Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines; P. R. Nitha, Manu M. Joseph, Greeshma Gopalan, Kaustabh Kumar Maiti,* K. V. Radhakrishnan* and Parthasarathi Das*, Organic & Biomolecular Chemistry, 2018, 16, 6430 (Impact Factor: 3.41).
  • Experimental and DFT studies for substituent effects on cycloadditions of C,N-disubstituted nitrones to cinnamoyl piperidine; Sutapa Mandal, Kaustabh K Maiti, Avijit Banerji, Thierry Prangé, Alain Neuman & Nivedita Acharjee*, Indian Journal of Chemistry, 2018, 57B, 108-119 (Impact Factor: 0.38).
  • Exploring the margins of SERS in practical domain: An emerging diagnostic modality for modern biomedical applications; Manu M. Joseph , Nisha Narayanan, Jyothi B. Nair, Varsha Karunakaran, Adukkadan N. Ramya, Palasseri T. Sujai , Giridharan Saranya, Jayadev S. Arya, Vineeth M. Vijayan and Kaustabh Kumar Maiti*, Biomaterials, 2018, 140-181 (Impact Factor: 10.31).
  • Magnetic properties of biocompatible CoFe2O4 nanoparticles using a facile synthesis; Annrose Sunny, Aneesh Kumar K.S., Varsha Karunakaran, Aathira M., Geeta R. Mutta, Kaustabh K. Maiti, V. Raghavendra Reddy, M. Vasundhara*, Nano-Structures & Nano-Objects, 2018, 69-76.
  • Calix[4]arene Based Redox Sensitive Molecular Probe for SERS Guided Recognition of Labile Iron Pool in Tumor Cells; Padincharapad Sreedevi, Jyothi B. Nair, Preethalayam Preethanuj, Benadicta S. Jeeja, Cherumuttathu H. Suresh*, Kaustabh Kumar Maiti*, and Ramavarma Luxmi Varma*, Anal. Chem., 2018, 90 (12), 7148-7153 (Impact Factor: 6.78).
  • pH-Controlled Nanoparticles Formation and Tracking of Lysosomal Zinc Ions in Cancer Cells by Fluorescent Carbazole–Bipyridine Conjugates; Karivachery V. Sudheesh, Manu M. Joseph, Divya S. Philips, Animesh Samanta, Kaustabh Kumar Maiti, and Ayappanpillai Ajayaghosh*, ChemistrySelect, 2018, 3, 2416 - 2422 (Impact Factor: 1.81).
  • SERS-Active Multi-Channel Fluorescent Probe for NO: Guide to Discriminate Intracellular Biothiols; Kondapa Naidu Bobba, Giridharan Saranya, Susan M. Alex, Nithya Velusamy, Kaustabh Kumar Maiti*, and Sankarprasad Bhuniya*, Sensors and Actuators B, 2018, 260, 165-173 (Impact Factor: 7.10).
  • Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation; Homan Kang, Sinyoung Jeong, Ahla Jo, Hyejin Chang, Jin-Kyoung Yang, Cheolhwan Jeong, San Kyeong, Youn Woo Lee, Animesh Samanta, Kaustabh Kumar Maiti, Myeong Geun Cha, Taek-Keun Kim, Sukmook Lee, Bong-Hyun Jun, Young-Tae Chang, Junho Chung, Ho-Young Lee,* Dae Hong Jeong,* and Yoon-Sik Lee*, Adv. Healthcare Mater., 2018, 7, 1700870 (Impact Factor: 7.36).

2017

  • Plasmonically Enhanced Galactoxyloglucan Endowed Gold Nanoparticles Exposed Tumor Targeting Biodistribution Envisaged in a Surface-Enhanced Raman Scattering Platform; Manu M. Joseph, Jyothi B. Nair, Kaustabh K. Maiti*, Sreelekha Therakathinal T*, Biomacromolecules, 2017, 18 , 4041-4053 (Impact Factor: 6.09).
  • Self-calibrated Fluorescent Probe Resembled as an Indicator of the Lysosomal Phosphatase Pertaining to the Cancer Cells; Arun Podder, Susan M. Alex, Mrinmoy Maiti, Kaustabh K. Maiti*, Sankarprasad Bhuniya*, J Photochem Photobiol B., 2017, 177, 105-111 (Impact Factor: 4.38).
  • Unveiling NIR Aza-Boron-Dipyrromethene (BODIPY) Dyes as Raman Probes: Surface-Enhanced Raman Scattering (SERS)-Guided Selective Detection and Imaging of Human Cancer Cells.; Adarsh N, Ramya A N, Kaustabh K. Maiti* and Ramaiah D.* Chem. Eur. J., 2017, 23, 14286 (Impact Factor: 4.85).
  • A Ratiometric Near-Infrared Fluorogen for the Real Time Visualization of Intracellular Redox Status during Apoptosis; Giridharan Saranya, Palapuravan Anees, Manu M. Joseph, Kaustabh K. Maiti,* and Ayyappanpillai Ajayaghosh*, Chem. Eur. J., 2017, 23, 7191 - 7195 (Impact Factor: 4.85).
  • Emergence of Gold-Mesoporous Silica Hybrid Nano-Theranostic: Dox-Encoded, Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication;Adukkadan N. Ramya, Manu M. Joseph,* Santhi Maniganda, Varsha Karunakaran, Sreelekha T.T,* and Kaustabh Kumar Maiti*,Small, 2017, 13, 1700819 (Impact Factor: 11.45).
  • Exploration of Biogenic Nano-chemobiotics Fabricated by Silver Nanoparticle and Galactoxyloglucan with an Efficient Biodistribution in Solid Tumor Investigated by SERS Fingerprinting; Manu M. Joseph, Jyothi B. Nair, Ramya N. Adukkadan, Neethu Hari, Raveendran K. Pillai, Ananthakrishnan J. Nair, Kaustabh Kumar Maiti,* and Sreelekha Therakathinal T, ACS Appl. Mater. Interfaces, 2017, 9, 19578-19590 (Impact Factor: 8.75).
  • Single cell lipid profiling of Scenedesmus quadricauda CASA-CC202 under nitrogen starved condition by surface enhanced Raman scattering (SERS) fingerprinting; A.N. Ramya , P.S. Ambily , B.S. Sujitha, Muthu Arumugam, Kaustabh Kumar Maiti*, Algal Research, 2017, 25, 200-206 (Impact Factor: 4.00)

2016

  • New Insight into a Cancer Theranostic Probe: Efficient Cell-Specific Delivery of SN-38 Guided by Biotinylated Poly(vinyl alcohol); Debabrata Dutta,Susan M. Alex, Kondapa Naidu Bobba, Kaustabh Kumar Maiti* and Sankarprasad Bhuniya*,ACS Appl. Mater. Interfaces., 2016, 8, 33430-33438 (Impact Factor: 8.75).
  • TEMPO-Oxidized Nanocellulose Fiber-Directed Stable Aqueous Suspension of Plasmonic Flower-like Silver Nanoconstructs for Ultra-Trace Detection of Analytes; Kallayi Nabeela, Reny Thankam Thomas, Jyothi B. Nair,Kaustabh Kumar Maiti, Krishna Gopa Kumar Warrier, and Saju Pillai, *, ACS Appl. Mater. Interfaces., 2016, 8 (43), pp 29242-29251 (Impact Factor: 8.75).
  • Guanidinium rich dendron-appended hydnocarpin exhibits superior anti-neoplastic effects through caspase mediated apoptosis; Bincy Mariyam Mathai, Manu M. Joseph, Santhi Maniganda, Jyothi B. Nair, J. S. Arya, Varsha Karunakaran, K. V. Radhakrishnan* and Kaustabh Kumar Maiti *, RSC Adv., 2016, 6, 52772-52780 (Impact Factor: 3.07).
  • Investigation of apoptotic events at molecular level induced by SERS guided targeted theranostic nanoprobe; Nisha Narayanan, Lakshmi V. Nair, Varsha Karunakaran, Manu M. Joseph, Jyothi B. Nair, Ramya A. N, Ramapurath S. Jayasree* and Kaustabh Kumar Maiti*, Nanoscale., 2016, 8, 11392-1139 (Impact Factor: 6.89).
  • New Insight of Tetraphenylethylene-based Raman Signatures for Targeted SERS Nanoprobe Construction Toward Prostate Cancer Cell Detection;Adukkadan N. Ramya, Manu M. Joseph, Jyothi B. Nair, Varsha Karunakaran,Nisha Narayanan, and Kaustabh Kumar Maiti*, ACS Appl. Mater. Interfaces., 2016, 8, 10220-10225 (Impact Factor: 8.75).
  • A Dual-Targeting Octaguanidine–Doxorubicin Conjugate Transporter for Inducing Caspase-Mediated Apoptosis on Folate-Expressing Cancer Cells ; Jyothi B. Nair, Manu M. Joseph, Saswat Mohapatra, M. Safeera, Surajit Ghosh*, T. T. Sreelekha*, and Kaustabh Kumar Maiti*, ChemMedChem., 2016, 11,702-712 (Impact Factor: 3.12)

2015

  • Aggregation induced Raman scattering of squaraine dye: Implementation in diagnosis of cervical cancer dysplasia by SERS imaging ; Nisha Narayanan, Varsha Karunakaran, Willi Paul, Karunakaran Venugopal, K. Sujathan, Kaustabh Kumar Maiti*,Biosensors and Bioelectronics., 2015, 70, 145-152 (Impact Factor: 10.25).
  • Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells; Jyothi B. Nair, Saswat Mohapatra, Surajit Ghosh*, Kaustabh K. Maiti*, Chem Commun, 2015, 51, 2403-2406 (Impact Factor: 5.99).
  • New insight of squaraine-based biocompatible surface-enhanced Raman scattering nanotag for cancer-cell imaging; AN Ramya, Animesh Samanta, N Nisha, Young-Tae Chang & Kaustabh Kumar Maiti* Nanomedicine., 2015;10(4), 561-571 (Impact Factor: 4.30).

2014

  • A lysosome-targeted drug delivery system based on sorbitol backbone towards efficient cancer therapy;Santhi Maniganda, Vandana Sankar, Jyothi B. Nair, K. G. Raghu and Kaustabh K. Maiti* Organic & Biomolecular Chemistry,2014, 12, 6564-6569 (Impact Factor: 3.41).

2013

  • Multiplexing SERS nanotags for the imaging of differentiated mouse embryonic stem cells (mESC) and detection of teratoma in vivo Samanta, A.; Das, R.; Park, S. J.; Maiti, K. K.; Chang, Y. T.* Am. J. Nucl. Med. Mol. Imaging, 2014, 4, 114-124 (Impact Factor: 2.52).
  • Surface enhanced Raman scattering in cancer detection and imaging; Marc Vendrell*, Kaustabh Kumar Maiti*, Kevin Dhaliwal, Young-Tae Chang, Trends in Biotechnology, 2013, 31, 249-257 (Impact Factor: 21.94).

Publication before joining to CSIR-NIIST

  • Multiplex Targeted in vivo Cancer Detection Using Sensitive Near-Infrared SERS Nanotags; Kaustabh Kumar Maiti, Dinish U. S, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Sung Jin Park, Malini Olivo Young-Tae Chang* Nano Today, 2012, 7, 85-93 (Impact Factor: 16.90).
  • Pluronic Triblock Copolymer Functionalized Gold Nanorods as Biocompatible Localized Plasmon Resonance Enhanced Scattering Probes for Dark-Field Imaging of Cancer Cells;Douglas Goh, Tianxun Gong, U. S. Dinish,* Kaustabh Kumar Maiti, Fu Chit Yaw, Ken-Tye Yong*, Malini Olivo* Plasmonics, 2012, 7, 595-601 (Impact Factor: 2.33).
  • Preparation of Blood-brain barrier-permeable Paclitaxel-carrier Conjugate and its Chemotherapeutic Activity in the Mouse Glioblastoma Model; Juyoun Jin, Woo Sirl Lee, Kyeung Min Joo, Kaustabh K. Maiti, Goutam Biswas, Wanil Kim, Kyong-Tai Kim, Se Jeong Lee, Kang-Ho Kim, Do-Hyun Nam,* and Sung-Kee Chung* Med. Chem. Commun., 2011, 2, 270-273 (Impact Factor: 2.39).
  • Multiplex Cancer Cell Detection by SERS Nanotags with Cyanine and Triphenylmethine Raman Reporters;Kaustabh Kumar Maiti, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Malini Olivo, Young-Tae Chang* Chem Commun, 2011, 47, 3514-3516 (Impact Factor: 5.99).
  • Development of Ultrasensitive Near-Infrared Raman Reporters for SERS-based in vivo Cancer Detection;Animesh Samanta, Kaustabh Kumar Maiti, Kiat-Seng Soh, Xiaojun Liao, Seong-Wook Yun, Ramaswamy Bhuvaneswari, Marc Vendrell, Hyori Kim, Shashi Rautela, Malini Olivo, Junho Chung, Young-Tae Chang*. Angew .Chem. Int. Ed., 2011, 50, 6089-6092 (Impact Factor: 16.82).
  • Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporters; JungKyun Im, Kaustabh K Maiti, Wanil Kim, Kyong-Tai Kim, Sung-Kee Chung* Bull. Korean Chem. Soc., 2011, 32(4), 1282-1292 (Impact Factor: 0.61).
  • Bioimaging: Raman probes for cancer diagnostics; A. Samanta, K. K. Maiti, M. Vendrell, Y. T. Chang, A*STAR Research (Highlights), published online on 17th August, 2011.
  • Development of Biocompatible SERS Nanotag with Increased Stability by Chemisorption of Reporter Molecule for in vivo Cancer detection; Kaustabh Kumar Maiti, Dinish U.S., Chit Yaw Fu, Jae-Jung Lee, Kiat-Seng Soh, Seong-Wook Yun, Ramaswamy Bhuvaneswari, Malini Olivo* , Young-Tae Chang* Biosensors and Bioelectronics, 2010, 26(2), 398-403 (Impact Factor: 10.25).
  • Rapid synthesis of nanoscale reporter tags offers a promising alternative to fluorescent labeling; K.K. Maiti, R. Bhuvaneswari, Y. T. Chang A*STAR Research (Highlights), published online on 26th May, 2010.
  • Combinatorial Synthesis of Triphenylmethine Library and Their Application in the Development of Surface Enhanced Raman Scattering (SERS) Probes; Sung Ju Cho, Young-Hoon Ahn, Kaustabh Kumar Maiti, Dinish U. S., Chit Yaw Fu, Praveen Thoniyot1, Malini Olivo1,3,4* Young-Tae Chang1,5* Chemical Communications, 2010, 46(5), 722-724 (Impact Factor: 5.99).
  • Chemical Synthesis and Proinflamatory Responses of Monophosphoryl Lipid A Adjuvant Candidates; Kaustabh K Maiti, Michael De Castro, Matthew Foote, Margreet Wolfert and Geert-Jan Boons* European Journal of Organic Chemistry, 2010, 80-91 (Impact Factor: 2.88).
  • Novel Lipidated Sorbitol-based Molecular Transporters for Non-viral Gene Delivery; Tomoko Higashi, Ikramy A. Khalil, Kaustabh K. Maiti, Woo Sirl Lee, Hidetaka Akita, Hideyoshi Harashima, and Sung-Kee Chung* Journal of Controlled Release, 2009, 136(2), 140-147 (Impact Factor: 7.94).
  • Toll-like receptor 2 can differentially recognize peptidoglycan fragments derived from Gram-positive and -negative bectria; Jinkeng Asong, Margreet Wolfert, Kaustabh K Maiti, Douglas Miller and Geert-Jan Boons* Journal of Biological Chemistry, 2009, 284(13), 8643-8653 (Impact Factor: 4.23).
  • Recent Advances in Cell-penetrating, Non-peptide Molecular Carriers; S.-K.Chung*, Kaustabh K Maiti and Woo Sirl Lee, International Journal of Pharmaceutics, 2008, 354, 16-22 (Impact Factor: 4.85).
  • Novel Guanidine-containing Molecular Transporters: Sorbitol-based Transporters Show High Intracellular Selectivity toward Mitochondria; Kaustabh K. Maiti, Woo Sirl Lee, Toshihide Takeuchi, Catherine Watkins, Marjan Fretz, Dong-Chan Kim, Shiroh Futaki, Arwyn Jones, Kyong-Tai Kim and Sung-Kee Chung* Angew .Chem. Int. Ed., 2007, 46, 5880-5884 (Impact Factor: 12.95).
  • Design, Synthesis, and delivery properties of Novel Guanidine containing Molecular Transporters built on Dimeric Inositol Scaffolds; Kaustabh K. Maiti, Ock-Youm Jeon, Woo Sirl Lee, Sung-Kee Chung*, Chem. Eur. J. 2007, 13, 762-775 (Impact Factor: 4.85).
  • Design, Synthesis and Membrane-Translocation studies of Inositol-based Transporters; Kaustabh K. Maiti, Ock-Youm Jeon, Woo Sirl Lee, Dong-Chan Kim, Kyong-Tai Kim, Toshihide Takeuchi, Shiroh Futaki and Sung-Kee Chung*, Angew .Chem. Int. Ed., 2006, 45, 2709-2712 (Impact Factor: 12.95).
  • 1,3-Dipolar cycloadditions; Part IV. Structure and Conformation of cycloadducts from Reaction of C-Aryl-N-phenylnitrones to substituted Cinnamic acid amides. Conformation of Cycloadducts from Reaction of; A. Banerji, Kaustabh K Maiti, S. Halder (nee Datta), c. Mukhopadhyay, J. Banerji, T. Prange and A. Nuuman, Monatshefte Chemie. 2000, 131, 901-911 (Impact Factor: 1.52).
  • 1,3-Dipolar cycloadditions; Part III - Cycloaddition of C,N-diarylnitrones to N-cinnamoyl Piperidines; A. Banerji, S. Halder (nee Datta), Kaustabh K Maiti, S. Basu(nee Sinha), T.Prange and A. Neuman. Ind. J. Chem., Section B, 1998, 37B, 105-119 (Impact Factor: 0.36).
  • Metal reagents in Organic Reactions. Part-VI. Oxidations of Indoles with Thalium (III) acetate; A.Banerji, R. Ray, S. Pal, D. Banerji and Kaustabh K Maiti, J. Indian chem. Soc., 1998, 75, 698-704 (Impact Factor: 0.15).

Patents

  • Screening kit for detection of grades of cervical cancer and process for the preparation thereof; Maiti, Kaustabh Kumar, Varsha Karunakaran, K.Sujathan; PCT Int. Appl. (2020), WO 2020021568 A1 20200130. Language: English, Database: CAPLUS, Date: 30th January, 2020.
  • A Diagnostic screening kit for simultaneous detection of clinically relevant biomarkers from breast cancer tissue samples using surface enhanced Raman scattering platform and process for the preparation thereof; Maiti, Kaustabh Kumar, K. Sujathan, Vishnu Priya Murali, Varsha K, Deepika S, Madhukrishnan M ; Indian Patent Application ref. No. 202011034768, dated 11.08.2020.
  • A method for preparing a surface enhanced Raman spectroscopy particle by encapsulation with biocompatible shell at elevated temperature; Liu, Shuhua; Wei, Shah Kwok; Low, Michelle; Wei, Seh Zhi; Han, Ming-Yong; Maiti, Kaustabh Kumar; Soh, Kiat Seng Jason; Unnimadhava Kurup Soudamini Amma, Dinish; Olivo, Malini; Chang, Young-Tae Singapore Pat. Appl. (2013), SG 187372 A1 20130228. | Language: English, Database: CAPLUS.
  • Surface enhanced raman spectroscopy (SERS) compounds, their conjugates with nanoparticles or analyte binding agents, their preparation, and their use in assays; By Chang, Young-Tae; Maiti, Kaustabh Kumar; Unnimadhava Kurup Soudamini Amma, Dinish; Fu, Chit Yaw; Olivo, Malini; Soh, Kiat Seng Jason; Yun, Seong-Wook U.S. Pat. Appl. Publ. (2012), US 20120128592 A1 20120524. | Language: English, Database: CAPLUS
  • Development of photostable near-ir cyanine dyes for in vivo imaging; By Chang, Young-Tae; Samanta, Animesh; Vendrell, Marc; Kang, Nam-Young; Maiti, Kaustabh Kumar; Soh, Kiat Seng; Unnimadhava Kurup Soudamini Amma, Dinish; Olivo, Malini PCT Int. Appl. (2011), WO 2011119114 A1 20110929. | Language: English, Database: CAPLUS
  • Development of photostable near-ir cyanine dyes for in vivo imaging; By Chang, Young-Tae; Samanta, Animesh; Escobar, Marc Vendrell; Kang, Nam-Young; Maiti, Kaustabh Kumar; Soh, Kiat Seng; Unnimadhava Kurup Soudamini Amma, Dinish; Olivo, Malini; Park, Sung-Jin U.S. Pat. Appl. Publ. (2013), US 20130101517 A1 20130425. | Language: English, Database: CAPLUS
  • Preparation of glycoside, oligosaccharide and cyclitol molecular transporter analogs with high permeability through biological membranes; By Chung, Sung-Kee; Maiti, Kaustabh Kumar; Lee, Woo Sirl; Jeon, Ock-Youm; Yu, Seok-Ho PCT Int. Appl. (2006), WO 2006115312 A1 20061102. | Language: English, Database: CAPLUS
  • Inositol based molecular transporters and processes for the preparation thereof; Sung-Kee Chung, Maiti, Kaustabh Kumar, Jeon Ock Youm, Seok-Ho Yu; PCT Int.Appl.(2005), 58pp. CODEN:PIXXD2 WO 2005/085159 A1 20050915 AN 2005: 1004682 CAPLUS
  • Inositol based molecular transporters and processes for the preparation thereof; Sung-Kee Chung, Maiti, Kaustabh Kumar, Jeon Ock Youm, Seok-Ho Yu ; U.S. Pat. Appl. Publ. (2006), 25pp., Pub. No.: US 2006/0280796 A1; Pub. Date: Dec. 14, 2006
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof; Sung-Kee Chung, Maiti, Kaustabh Kumar, Jeon Ock Youm, Seok-Ho Yu; Korea patent, Patent No. 10-0699279, The Application No. 2005-0035410 (2005.04.28).
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof; Sung-Kee Chung, Maiti, Kaustabh Kumar, Jeon Ock Youm, Seok-Ho Yu; PCT Int.Appl.(2006), 74pp. CODEN:PIXXD2 WO 2006/115312 A1 20061102 AN 2006: 1155705 CAPLUS
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof; Sung-Kee Chung, Maiti, Kaustabh Kumar, Jeon Ock Youm, Seok-Ho Yu;U.S. Patent No.: US 7,846,975 B2, A1; Pub. Date: Dec. 7, 2010
  • Molecular transporters based on alditol or inositol and processes for the preparation thereof; Sung-Kee Chung, Maiti, Kaustabh Kumar, Woo Sirl Lee; Korea patent, The Application No. 2006-86106 (2006.09.07)
  • Molecular transporters based on alditol or inositol and processes for the preparation thereof; Sung-Kee Chung, Maiti, Kaustabh Kumar, Woo Sirl Lee U.S. Pat. Appl. Publ. (2008), 32pp.,Cont.-in-part of U.S. Ser. No. 815,339. CODEN: USXXCO US 2008039421 A1 20080214 Patent written in English.
Academic Qualification
  • PhD: Synthetic organic chemistry, University of Calcutta, India, 2001
    Thesis: “Studies on Cycloaddition Reactions and Organometallic Compounds”
    Thesis Supervisor: Prof. Avijit Banerji, Department of Pure Chemistry, University of Calcutta
  • M.Sc.: Chemistry (Specialization in Organic Chemistry), University of Calcutta, India, 1993
  • B.Sc. (Honours in Chemistry), University of Calcutta, India, 1991
Research Interest

My research interest consists of the interface of chemistry, biology, and nanoscience with an effort of interdisciplinary teamwork and contribution to the healthcare sector focusing on translational research.

Area 1: Diagnostics and Nano-theranostics (Nanomedicine) for Clinical Translation

Chronological development of common methods used in molecular biology, biochemistry, cytopathology, and genetics are based on various manipulations of analysis of metabolites e.g., amino acids, nucleic acids and lipids. Modern techniques are explored through various aspects of spectroscopy where Raman spectroscopy and its modified version i.e., surface-enhanced Raman spectroscopy (SERS) evolved as a potential ultrasensitive diagnostic tool for a wide range of disease detection and spread over in the healthcare sector. In biomedicine nanoparticles (NPs) were extensively investigated in drug delivery and imaging. Nanomaterials are diverse in their composition and hence can be categorized as carbon, metal and inorganic and organic NPs. Carefully fabricated NPs with cell targeting ligands could be loaded with suitable cargo to assemble ‘nanotheranostic’ which enables monitoring therapy in a real-time manner so as to improve the safety and drug efficacy for personalized medicine. The distinctive features of NPs with the relatively smaller particle size along with a larger surface area and appealing optical and electrical properties ensure their role as carriers in designing nanotheranostics.

Focused Projects on:

  • New Generation Diagnostic Nanoparticle probes: SERS-tags for Label-free / SERS-labelled / SERS-kit for various cancer biomarker detection in multiplexing mode.
    (a) Ultrasensitive, non-invasive and early detection of human cancer by SERS and Artificial Intelligence (AI) dual-modality - An early detection technology
    (b) Detection of infectious diseases by Label-free SERS and AI
    (c) Early detection and monitoring of neurodegenerative disorders, mainly Alzheimer’s Diseases using SERS-nanoprobes - A SERS-based immunoassay techniques.
  • Multimodal theranostic nano-probes based on SERS & and fluorescence as diagnostic modalities and PDT, PTT, Chemo and immunotherapy.
    (a) Multimodal Cancer therapy by Targeted nano-carrier drug delivery system (Nanomedicine): Chemo-photo; Chemo-immunotherapy
    (b) Combined therapy on diabetic retinopathy using a nano-delivery system

Area 2: Bio-Organic and Medicinal Chemistry

Medicinal plants have demonstrated their potential as a repository of bioactive molecules with promising therapeutic potential and represent an important pool for the identification of novel drug leads. In an attempt to investigate new phytochemical entities (NPCEs), naturally occurring phytomolecules are subjected to semi-synthetic modification which transforms into pharmacologically active NPCEs as a lead candidate for clinical translation. In-depth investigations of underlying molecular mechanisms were ruled out using detailed in vitro and in silico approaches. Moreover, fundamental structural changes have been observed during many physiological processes which lead to the development of disease (e.g., cancer) progression.

Focused Projects on:

  • Semi-synthetic modification of bioactive natural products isolated from plants: New Phytochemical Entities (NPCEs) as advanced Hits / Leads in the area of cancer and other non-communicable diseases
  • In vitro cell-based assays of HIT / Advanced HITs including proteomics and genomics studies in order to propose the mechanistic pathways that will have the potential for further pre-clinical and clinical trials with Industry support (Pharma and Biotech)
  • Phytochemical profiling of marker compounds by evaluation of Raman fingerprints (signature peaks) with their classification viz., alkaloids, steroids, polyphenols, terpenoids, etc.

Area 3: Glycobiology:

Metabolic glycan labelling & glycan associated disorder in a cellular system

Glycosylation is a major post-translational modification prevalent in most eukaryotes. Glycans cover the cell surface and play a decisive role in cell–cell interactions and cell migration during various physiological processes such as fertilization, embryogenesis and immune responses. I have planned to explore Raman imaging which will be utilized as an alternative technique for glycan detection since it is an ultrasensitive technique in terms of enhanced signal intensity. The inherent drawbacks from fluorescent modality in glycan labelling can be eliminated with the help of Raman spectroscopic techniques like coherent ant Stokes Raman scattering (CARS), stimulated Raman scattering (SRS) and surface-enhanced Raman scattering (SERS). The idea in this direction is to utilise N alkyl derivatives / N acetyl derivatives of glucose, galactose and mannose analogues are predominantly fit for glycan labelling entities. The Alkyne group will be introduced as the bioorthogonal functionality in the glycan precursors since it has the maximum cross-sectional area in SERS when compared to other bioorthogonal functional groups, which is metabolically labelled at the terminal site of the glycan chain ended with sialic acid by biosynthetic pathway.

Focused Projects on:

  • Evaluate aberrant glycosylation behaviours of cancer cells with different metastatic potentials of cancer cells i.e., highly metastatic cancer cells to comparatively lower metastatic to normal cells. The metastatic progression assessment and establish a robust, sensitive, and accurate SERS-based platform
  • New Glycan labelling sugar analogues for Metabolic Glycan labelling (MGL) to investigate aberrant glycosylation in cancer cells by Raman imaging
  • Investigate new metabolic pathways and correlate with the disease progression by metabolic oligosaccharide engineering (MOE) strategy
Projects

Major Projects :

NON-CSIR Project:

Ongoing:

  • Project Title: “Technology for the Early Detection of Cancer from Blood Sample using SERS and Artificial Intelligence- A Novel Technique” - Principal Investigator
    Funding Agency: Tata Elxsi (CSR Fund), 74 Lakhs ; (October 2022- January 2024)
  • Project Title: Development of a sandwich model magnetic capture system for the detection of pancreatic cancer biomarkers in serum by SERS-based immune assay - Principal Investigator
    Funding Agency: ICMR-DHR. 45 Lakhs (3 years) (Nov, 2021 to Nov, 2024)
  • Project Title: Diagnostic Evaluation of a SERS-Nanoprobe Based Immunosensor for Early Detection of Alzheimer’s Disease Biomarkers from Blood - Principal Investigator
    Funding Agency: ICMR 102.98 Lakhs (3 year); (April, 2022- March, 2025)

Completed:

  • Project Title: “Biocompatible Combined Polymer-Polysaccharide Core-shell VEGF-Targeted Nano-Carrier For Sustained Intraocular Pharmacotherapy Towards Diabetic Retinopathy”- Principal Investigator
    Funding Agency: DBT, 51.23 Lakhs (3 year); (September, 2018- June, 2022)
  • Project Title: “Engineering intelligent theranostic nanocarrier for targeted therapy and diagnosis of cancer”- Principal Investigator from NIIST
    Funding Agency: DST, SERB, 16.6 Lakhs (3 year); (August, 2018- July, 2021)
  • Project Title: "Design A Smart Drug-Delivery System Using Activatable Cell- Penetrating Peptides and Scaffold Based Non-peptide Carriers For Targeting Human Cancer" - Principal Investigator
    Funding agency: DST (SERB) : 27 Lakhs; ( June 2013 to May, 2016)
  • Project Title: “Gold Nanorod Based Targeted Nanoprobe For Cancer Theranostics: Diagnosis By Surface Enhanced Raman Scattering (Sers) And Fluorescence Imaging And Therapy By PDTand PTT” - Principal Investigator
    Funding Agency: DBT; 84.224 Lakhs (3 years); (March, 2016-Feb, 2019)
  • Project Title: Engineering Nanostructured Surfaces for Developing SERS Sensing Platform - Co-Principal Investigator
    Funding Agency: DBT 71.5 Lakhs (3 year); (September, 2018- March, 2022)
  • Project Title: “Development Of Multiplexing Detection Platform Of Breast Cancer Biomarkers By Non-Invasive Surface Enhanced Raman Scattering (SERS) Nanoprobe”- Principal Investigator
    Funding Agency: DST Nano Mission, 37.2 Lakhs (3 years); (August, 2017 – Dec, 2020)

List of CSIR Network Projects: 12th FYP ( March, 2012 to March, 2017)

  • Project Title: Molecules To Materials To Devices (M2D)
    Lab co-ordinator from CSIR-NIIST
    Budget: 831 Lakhs (NIIST)
    Major Achievement: Probes for SERS-based detection of cervical cancer (CSIR-NIIST; TRL 4) - These nanoprobes are being validated in clinical samples through active collaboration with Regional Cancer Centre (RCC), Trivandrum (TLR 4) - Project Leader
  • Project Title: Nanomaterials: Application and Impact On Safety, Health And Environment (NanoSHE)
    Nodal Scientist from CSIR-NIIST
    Budget: 116 Lakhs
    Major Achievement: Gold Nanorod based Theranostic Nanoprobe for Photothermal Chemotherapy to MMP2 expressed cancer tumors : (TRL3) - Nodal officer from NIIST
  • Project Title: Natural Products as Affordable Healthcare Agents (NaPaHa)
    Participating Scientist from CSIR-NIIST
    Budget: 413 Lakhs
    Major Achievement: Isolation Of Anticancer Agent From Hydnocarpus Wightiana Blume and Its Semi Synthetic Modifications For Enhanced Anticancer Activity - Participating Scientist from NIIST

CSIR Mission Mode Project (March, 2018- February, 2020)

  • Project Title: “Nanobiosensors and Microfluodics for Healthcare”
    “Development of SERS-Nanoprobe for Multiplexing Diagnosis of Breast and Lung Cancer Biomarkers in Tumor Tissue Samples By Raman Fingerprint”:
    Project Leader - CSIR-NIIST; Budget: 749 Lakhs (For CSIR-NIIST)

CSIR FTT Project ( Aug., 2018 - March, 2020)

  • Project Title: Development of Cellular Sensors: Biocompatible fluorescent molecules for sensing and cellular imaging of pH, Zn2+ and reactive oxygen species
    Co-Principal Investigator / Budget : 75 Lakhs

CSIR FTT Project ( June, 2020 – March, 2022)

  • Project Title: Customized Portable Raman spectrophotometric device for multiplex detection of breast cancer biomarkers
    Co-Principal Investigator / Budget : 132 Lakhs

CSIR Covid Project (MLP 0047) ( June, 2020 – Nov 2020)

  • Project Title: Development of Ultrasensitive, Rapid and Portable system for COVID-19 screening using Label-free Raman Fingerprinting and AI
    Principal Investigator / Budget : 12 lakhs

CSIR Covid Project (MLP0048) ( Aug, 2020 – March, 2021)

  • Project Title: Multiplexed lateral-flow device(s) for detection of COVID-19 (CSIR-NllST: COVID-19 ViralRNA detection kit with ultra-bright oligoprobes for the capture and detection of viralRNA via Lateral Flow based devices)
    Co-Principal Investigator / Budget: 39 lakhs