Dr.Sasidhar B.S.

Dr.Sasidhar B.S.

Sasidhar B S received his M.Sc. degree in Organic Chemistry in the year 2006 from the Department of Chemistry, Gulbarga University, Gulbarga. He started his professional career in leading pharmaceutical R&D’s in India; where he worked as Junior Research Scientist at Ranbaxy Laboratories Ltd., Gurgaon, and Research Scientist at Jubilant Life Sciences Ltd., (Jubilant Generics Ltd.) Nanjanagud during 2006-2008. He was involved in process development of several generic drugs and in the synthesis of New Chemical Entities (NCE’s) for the drug discovery program. After the brief industrial experience, he moved to Department of Chemistry, Gulbarga University for his PhD and obtained his doctorate degree in 2012 under the guidance of Prof. Jayaprakash S Biradar for the thesis entitled “Synthesis of Novel Heterocycles of Biological Importance”. In 2012 (October) Dr. Sasidhar joined as Scientist at Chemical Sciences and Technology Division, CSIR-NIIST.

Dr. Sasidhar’s group is focused on the interdisciplinary aspects of chemistry with respect to medicinal and material properties. This includes methodology, target-oriented synthesis, medicinal chemistry, and phytochemistry. The focused activity of the group on fundamental aspects of organic and medicinal chemistry has led to the successful translational projects.

Professional Experience

Professional Experience

  • Senior Principal Scientist & Professor (AcSIR), CSIR-NIIST, Thiruvananthapuram, India (October 2024- to date).
  • Principal Scientist & Associate Professor (AcSIR), CSIR-NIIST, Thiruvananthapuram, India (October 2019- October 2024).
  • Senior Scientist & Assistant Professor (AcSIR), CSIR-NIIST, Thiruvananthapuram, India (October 2016- October 2019).
  • Scientist & Assistant Professor (AcSIR), CSIR-NIIST, Thiruvananthapuram, India (October 2012- October 2016).
  • PhD, at Depart of Chemistry, Gulbarga University, Gulbarga, Karnataka, India. (2008 - 2012).
  • Research Scientist, Scale-up and Process R&D, Jubilant Life Sciences Ltd, Nanjanagud, India (2007-2008).
  • Research Trainee, Ranbaxy Laboratories Ltd., Gurgaon, India (2006-2007).
Achievements & Awards

Awards & Fellowships

  • CSIR-Young Scientist Award -2019, from the Council of Scientific & Industrial Research (CSIR), Ministry of Science and Technology, Govt. of India.
  • Kerala State Young Scientist Award (KSYSA) - 2017. From the Kerala State Council for Science, Technology & Environment (KSCSTE), Ministry of Science and Technology, Govt. of Kerala.
  • ISAS-Young Scientist Award-2022, from the Indian Society for Analytical Scientists, Kolkata.
  • RSC Chemical Communications Emerging Investigator - 2021, from the Royal Society of Chemistry, London.
  • Elected as Fellow of the Indian Chemical Society - 2020, from the Indian Chemical Society, Kolkata.
  • Associate Fellow of the Indian Academy of Sciences - 2019, from the Indian Academy of Sciences (IASc), Bangalore.
  • Yong Scientist Award 2009 - NACEAC-2009, University of Mysore.
  • CSIR-Senior Research Fellow, 2010-2012.
  • UGC-RFSMS (Research Fellowship in Science for Meritorious Students), 2008-2010.
  • University Merit Fellowship for Research, 2007-2008.
Publications

Publications

2025

  • Multi-Target-Directed Triazole Derivatives: Design, Synthesis, and Evaluation of Synergistic Modulation in Alzheimer’s Disease. Anjali Sobha, Lekshmy Krishnan, Sreelakshmi Vijayakumar, Shareef Shaik, Aravinda Pai, Jayamurthy Purushothaman, and Sasidhar B. Somappa*. ACS Chem. Neurosci. 2025, 16, 19, 3873-3885.
  • Targeting Alzheimer’s pathology: Tetralone- and thiochromanone-based benzyl pyridinium derivatives as promising multi-target-directed ligands. Anjali Sobha, Lekshmy Krishnan, Shareef Shaik, Aravinda Pai, Jayamurthy Purushothaman, Kumaran Alaganandam, Sasidhar B. Somappa*. Bioorganic & Medicinal Chemistry, 2025, 130, 118369.
  • Catalyst to cure: applications of a new copper-based nanocatalyst in organic synthesis and cancer treatment. Harini G. Sampatkumar, Srushti S. Gundakanal, Byresh Gowda, Sudhanva M. S., Siddalingeshwar V. D., B. S. Sasidhar, Alejandro Bugarin and Siddappa A. Patil. Chem. Commun., 2025, 61, 101-104.
  • Base-promoted transition-metal-free synthesis of quinazolinones with antioxidant activity. Maruboina Hemanth Kumar, Harini G Sampatkumar, Sanjana S Talekar, Manoj V Mane, Vaishnavi Shashidhara, Madhavarani Alwarsamy, B S Sasidhar, Ling Shing Wong, Manjula Subramaniam, Meenakshi Verma, Shifa Wang, Asad Syed, Siddappa A Patil. Org. Biomol. Chem., 2025, 23, 7138-7144.
  • Dual-acting β-Aminothiochromones: Design, synthesis, and evaluation as antimicrobial and anti-angiogenic agents. MS Ajay Krishna, KT Ashitha, Meghashyama Prabhakara Bhat, Muthuraj Rudrappa, KS Sandhya, NC Lima, D Basavaraja, Sunil Varughese, Sreenivasa Nayaka, Sasidhar B Somappa. Bioorg. Med. Chem. Lett. 2025, 120, 130140.
  • Spiro-heterocycles: Recent advances in biological applications and synthetic strategies. Basavaraja D, Siddalingeshwar V. Doddamani, Athira C. S, Aiswarya Siby, Sreelakshmi V, Ancy A, Sasidhar B. Somappa. Tetrahedron, 2025 173, 134468.
  • Efficient and green: biowaste-derived N-rich carbon for palladium-catalyzed CO gas-free carbonylative annulation with DFT insights. Maruboina Hemanth Kumar, Harini G Sampatkumar, Sanjana S Talekar, Arnet Maria Antony, Manoj V Mane, B S Sasidhar, Manjula Subramaniam, Ling Shing Wong, Asad Syed, Siddappa A Patil. Catalysis Science & Technology, 2025,15, 3626-3637.
  • A sustainable preparation of palladium nanoparticle on waste plastic derived carbon: One step towards the development of peroxidase-mimic mercaptoacetic acid sensor and OER activity. Harini G. Sampatkumar, Abhinandan Patra, Arnet Maria Antony, Chandra Sekhar Rout, B.S. Sasidhar, Ramesh B. Dateer, Siddappa A. Patil. Chemical Engineering Science, 2025, 121334.
  • Biomedically active supported bimetallic PdxCu1-x nanocomposites and their application for organic synthesis. Masira I Chamanmalik, Byresh B Kempegowda, Sasidhar B Somappa, Siddappa A Patil. Materials Today Chemistry, 2025, 48, 10294.

2024

  • A selective photoinduced radical O-alkenylation of phenols and naphthols with terminal alkynes. V. Praveen Kumar, C. S. Athira, B. Mohan, S. Priya and B. S. Sasidhar. Chem. Commun., 2024, 60, 9813-9816.
  • Linker-based Pharmacophoric Design and Semi-synthesis of Labdane Conjugates Active Against Multi-Faceted Inflammatory Targets. Mohan, Sangeetha; Krishnan, Lekshmy; Madhusoodanan, Nithya; Sobha, Anjali; Jalaja, Renjitha; Vankadari, Naveen; Purushothaman, Jayamurthy; Somappa, Sasidhar. ACS J. Agric. Food Chem. 2024, 72, 12, 6389-6401. Special Issue: Bioactive constituents, metabolites and functions.
  • Ligand-Based Pharmacophoric Design and Anti-inflammatory Evaluation of Triazole Linked Semisynthetic Labdane Conjugates. Sangeetha Mohan, Lekshmy Krishnan, Nithya Madhusoodanan, Anjali Sobha, Alansheeja D Babysulochana, Naveen Vankadari, Jayamurthy Purushothaman, Sasidhar B Somappa. ACS Medicinal Chemistry Letters, 2024, 15, 8, 1260-1268.
  • TBD-Mediated Diastereoselective Access to Functionalized 3-Alkenyl-2-oxindoles via the Tandem Reaction of Isatins and Allenoates. Athira C Santhoshkumar, Basavaraja Durugappa, Geethu Venugopal, Mohan Banyangala, Sasidhar B Somappa. J. Org. Chem. 2024, 89, 19, 14021-14027.
  • Design and discovery of carboxamide-based pyrazole conjugates with multifaceted potential against Triple-Negative Breast cancer MDA-MB-231 cells. KT Ashitha, S Lakshmi, S Anjali, Ajay Krishna, Ved Prakash, Sadasivam Anbumani, S Priya, Sasidhar B Somappa. Bioorganic & Medicinal Chemistry Letters, 2024, 15, 129960.
  • Novel small molecule-based acetylcholinesterase (AChE) inhibitors: From biological perspective to recent developments. Anjali Sobha, Anand Ganapathy, Sangeetha Mohan, Nithya Madhusoodanan, Alansheeja D Babysulochana, Kumaran Alaganandan, Sasidhar B Somappa. European Journal of Medicinal Chemistry Reports, 2024, 12, 100237.
  • A Comprehensive Overview of Coumarinyl-Triazole Hybrids as Anticancer Agents. Aravind R. Nesaragi, Jari S. Algethami, Mabkhoot Alsaiari, Saeed A. Alsareii, Basavarajaiah Suliphuldevara Mathada, Srikantamurthy Ningaiah, B.S. Sasidhar, Farid A. Harraz, Siddappa A. Patil. Journal of Molecular Structure, 2024, 1302, 137478.
  • Palladium nanoparticle immobilized on coconut coir extract coated boron carbon nitride: A green and sustainable nanocatalyst for cross-coupling reactions and HER studies. Bhuwaneshwari Chandrashekharan, Harini G. Sampatkumar, Dani George, Arnet Maria Antony, Siddalingeshwar V. Doddamani, B. S. Sasidhar, R. Geetha Balakrishna, Siddappa A. Patil. Diamond and Related Materials, 2024, 147, 111261.
  • N -heterocyclic carbene functionalized boehmite-supported silver nanoparticles as nanocatalyst for reduction of environmental pollutants. Aakhila Banu, Arnet Maria Antony, B. S. Sasidhar, M. Faisal, Farid A. Harraz, Siddappa A. Patil. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 697, 134372.
  • Flavone-C-glycosides from Cassia auriculata L. as possible inhibitors of phosphodiesterase-5 (PDE5): in vitro, molecular docking and molecular dynamics studies. Anand Ganapathy A, Vijayakumari Mahadevan Hari Priya, Krishnaprasad Baby, Sreelekshmy Bindhu, Raji Jayan, Raman Krishnamoorthi, Sasidhar Balappa Somappa, Yogendra Nayak, Alaganandam Kumarana. Journal of Biomolecular Structure and Dynamics, 2024, 1-23.

2023

  • DBU-Catalyzed Diastereo/Regioselective Access to Highly Substituted Spiro-oxetane Oxindoles via Ring Annulation of Isatins and Allenoates. Basavaraja Durugappa, Athira C S, Siddalingeshwar V. Doddamani, and Sasidhar B. Somappa. J. Org. Chem. 2023, 88, 13, 8882-8888.
  • Diastereoselective Synthesis of Fused Tricyclic Pyridopyrimidines via Tandem Cyclization of Allenoates and Cyclic Amidines. Athira, C. Santhoshkumar, Basavaraja Durugappa, Siddalingeshwar V. Doddamani, Aiswarya Siby, Praveen K. Valmiki, and Sasidhar B. Somappa. Org. Lett. 2023, 25, 42, 7711-7715.
  • Waste biomass-derived carbon-supported palladium-based catalyst for cross-coupling reactions and energy storage applications. Manjunatha Kempasiddaiah, K. A. Sree Raj, Vishal Kandathil, Ramesh B. Dateer, B. S. Sasidhar, C. V. Yelamaggad, Chandra Sekhar Rout, Siddappa A. Patil. Applied Surface Science, 2023, 570 (30), 151156.
  • Investigation of embelin synthetic hybrids as potential COVID-19 and COX inhibitors: Synthesis, spectral analysis, DFT calculations and molecular docking studies. Basavarajaiah Suliphuldevara Mathada, N. Jeelan Basha, Prashantha Karunakar, Ganga Periyasamy, Sasidhar B. Somappa, Mohammad Javeed, S.Vanishree. Journal of Molecular Structure, 2023, 1273, 134356.
  • Green approach in anticorrosive coating for steel protection by Gliricidia sepium leaf extract and silica hybrid. Krishnapriya Karattu Veedu, Mohan Banyangala, Thejus Peringattu Kalarikkal, Sasidhar Balappa Somappa, Nishanth Karimbintherikkal Gopalan. Journal of Molecular Liquids, 2023, 369, 120967.
  • Palladium nanoparticles grafted on phytochemical functionalized biochar: A sustainable nanozyme for colourimetric sensing of glucose and glutathione. Aakhila Banu, Arnet Maria Antony, B. S. Sasidhar, Shivaputra A. Patil , Siddappa A. Patil. Molecules, 2023. 28, 6676.
  • Ethnobotanical significance of medicinal plants: Beta-amyloid and tau aggregation inhibitors against Alzheimer's disease. A. Anand Ganapathy, Vijayakumari M. Haripriya, Niyati Acharya, Sasidhar B. Somappa, Alaganandam Kumaran. Journal of Biochemical and Molecular Toxicology, 2023, 37, e23339.
  • Pyrazole appended hetero-hybrids: Bioisosteric design, synthesis, in silico and in vitro antibacterial and anti-inflammatory evaluations. Anjali S, Sangeetha M, Nithya M, Gopika V. Krishnan, Sunil Varughese, B.S. Dileep Kumar, Srikantamurthy N, Shridevi D, Sasidhar B. Somappa. Journal of Molecular Structure, 2023, 1289, 135780-93.
  • Biomacromolecule supported N-heterocyclic carbene-palladium(II) as a novel catalyst for Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions. Arnet Maria Antony, Masira Imtiyaz Chamanmalik, Vishal Kandathil, Harini G. Sampatkumar, B. S. Sasidhar, C. V. Yelamaggad & Siddappa A. Patil. Cellulose, 2023, 30, 7551-7573.

2022

  • Multicomponent Synthesis of Spiro-dihydropyridine oxindoles via Cascade Spiro-cyclization of Knoevenagel /aza-Michael Adducts. Durugappa, Basavaraja; C S, Athira; V. D., Siddalingeswar; Thiruthi, Ashitha; Somappa Sasidhar, Journal of Organic Chemistry, 2022. https://doi.org/10.1021/acs.joc.2c01063
  • Ethylbenzene Hydroperoxide: An Efficient Oxidizing Agent for Diastereoselective Synthesis of Spiro-epoxy Oxindoles. Praveen Kumar Valmiki, Mohan Banyangala, Sunil Varughese and Sasidhar B Somappa. Tetrahedron Letters, 2022, 108, 154126.
  • Marine Based Natural Products: Exploring the Recent Developments in the Identification of Antimicrobial Agents. Sangeetha Mohan, Ajay Krishna, Sasidhar B Somappa. Chemistry and Biodiversity, 2022, e202200513.
    Special issue: Unlocking the Biomedical Potential of Marine Natural Products.
  • Cu(OAc)2 Catalyzed Aerobic Oxidative 2-Aryl-3-acylquinoline Synthesis via Aza-Michael Addition and Aldol Condensation of alpha,beta-Unsaturated ketones and 2-Aminobenzyl alcohols. Athira C S, Basavaraj D, Praveen K. Valmiki, Shridevi D, Sasidhar B. Somappa. Tetrahedron Letters, 2022, 104, 154043.
  • Recent Advances in the Transition Metal-Free Synthesis of Heterocycles from alpha, beta-Unsaturated Ketones. Kizhakkan Thiruthi Ashitha, Ajay Krishna M S, Basavaraja D and Sasidhar Balappa Somappa. Chem. Front., 2022, 9, 5306.
  • Comprehensive review on medicinal applications of coumarin-derived imine-metal complexes. Siddappa A Patil, Vishal Kandathil, Anjali S, Sasidhar B S, Max R Feldman, Alejandro Bugarin, Shivaputra Patil. Molecules, 2022, 27, 5220.
    Special issue: Biologically active heterocyclic compounds.
  • An Insight into the Recent Developments in Anti-infective Potential of Indole and Associated Hybrids. Basavarajaih M, Sasidhar B Somappa. Journal of Molecular Structure, 2022, 1261, 132808.
  • The Nano-Based Catalyst for the Synthesis of Benzimidazoles. Rangappa S. Keri, Vinayak Adimule, Pravin Kendrekar, B. S. Sasidhar. Topics in Catalysis, 2022, https://doi.org/10.1007/s11244-022-01562-0.
  • Pd/Fe3O4 supported on bio-waste derived cellulosic-carbon as a nanocatalyst for C-C coupling and electrocatalytic application. Vishal Kandathil, Akshay Moolakkil, Pranav Kulkarni, Alaap Kumizhi Veetil, Manjunatha Kempasiddaiah, Sasidhar Balappa Somappa, R. Geetha Balakrishna, Siddappa A. Patil. Front. Chem. Sci. Eng., 2022, https://doi.org/10.1007/s11705-022-2158-y.
  • Phosphorescent Iridium Molecular Materials as Chemosensors for Nitroaromatic Explosives: Recent Advances. Anjali S, Sasidhar B S and M L P Reddy. Comments on Inorganic Chemistry, 2022, https://doi.org/10.1080/02603594.2022.2090347
  • Antibacterial natural products from microbial and fungal sources: a decade of advances. Sangeetha Mohan, Ajay Krishna, Manasa Chandramouli, Rangappa S. Keri, Siddappa A. Patil, Srikantamurthy Ningaiah, Sasidhar B. Somappa. Molecular Diversity, 2022, https://doi.org/10.1007/s11030-022-10417-5.
  • Synthetic and Natural Coumarins as Potent Anticonvulsant Agents: A Review with Structure-Activity Relationship. Rangappa Keri, Srinivasa Budagumpi, Sasidhar B. S. J Clin Pharm Ther. 2022; 00:1-17.
  • Eco-friendly anticorrosive epoxy coating from Ixora leaf extract: A promising solution for steel protection in marine environment. Krishnapriya Karattu Veedu, Sangeetha Mohan, Sasidhar Balappa Somappa, Nishanth Karimbintherikkal Gopalan. Journal of Cleaner Production, 2022, 340, 130750.

2021

  • Base-enabled access to diastereoselective spirofuran oxindoles and ?-functionalized allenoates. Basavaraja D., Ajay Krishna M. S., Jagadeesh Krishnan, Athira C. S., Amrutha R. R., Eringathodi Suresh and Sasidhar B. Somappa. Commun., 2021, 57, 1746-1749.
  • Waste biomass-derived carbon-supported palladium-based catalyst for cross-coupling reactions and energy storage applications. Manjunatha Kempasiddaiah, K. A. Sree Raj, Vishal Kandathil, Ramesh B. Dateer, Sasidhar, C. V. Yelamaggad, Chandra Sekhar Rout, Siddappa A. Patil. Applied Surface Science, 2021, 570 (30), 151156.
  • Anti-hyperlipidemic Potential of Natural Product Based Labdane-pyrroles via Inhibition of Cholesterol and Triglycerides Synthesis. Renjitha Jalaja, Shyni G. Leela, Mangalam S. Nair, Raghu K. Gopalan, and Sasidhar B. Somappa. Bioorganic Chemistry, 2021, 108, 104664.
  • Zerumin A attenuates the inflammatory responses in LPS-stimulated H9c2 cardiomyoblasts. G. L. Shyni, J. Renjitha, Sasidhar B. Somappa, K. G. Raghu. Journal of Biochemical and Molecular Toxicology, 2021, 35, e22777.
  • Epoxyazadiradione induced apoptosis/anoikis in triple negative breast cancer cells MDA MB-231 by modulating diverse cellular effects. Lakshmi S, Renjitha J, B Sasidhar S, Sulochana Priya. Journal of Biochemical and Molecular Toxicology, 2021, 35,e22756
  • A Green and Sustainable Cellulosic-Carbon Shielded Pd-MNP Hybrid Material for Catalysis and Energy Storage Applications. Vishal Kandathil, Alaap Kumizhi Veetil, Abhinandan Patra, Akshay Moolakkil, Manjunatha Kempasiddaiah, Sasidhar Balappa Somappa, Chandra Sekhar Rout & Siddappa A. Patil. Journal of Nanostructure in Chemistry. 2021, org/10.1007/s40097-020-00375-5.
  • An efficient, multicomponent synthesis of aminoalkylnaphthols via Betti reaction using ZSM-5 as a recoverable and reusable catalyst. Rangappa S. Keri, Mahadeo Patil, Srinivasa Budagumpi, S. Sasidhar. Appl Organometal Chem. 2021, e6316. DOI: 10.1002/aoc.6316 .
  • Azadiradione-loaded liposomes with improved bioavailability and anticancer efficacy against triple negative breast cancer. Fardous F.El-Senduny, Miram Altouhamy, Gamal Zayed, Choudhary Harsha, Renjith Jalaja, Sasidhar Balappa Somappa, Mangalam S. Nair, Ajaikumar B. Kunnumakkara Fahd M. Alsharif, Farid A. Badria.Journal of Drug Delivery Science and Technology, 2021, 102665.
    https://doi.org/10.1016/j.jddst.2021.102665.
  • Palladium-catalyzed denitrogenative cross-coupling of aryl halides with arylhydrazines under mild reaction conditions. Manjunatha Kempasiddaiah, Vishal Kandathil, Ramesh B. Dateer, S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Transition Metal Chemistry. 2021, 46, 273-281.

2020

  • Advanced Glycation End-products (AGE) Trapping Agents: Design and Synthesis of Nature Inspired Indeno[2,1-c]pyridinones. Anaga Nair, D. Basavaraja, Billu Abraham, P Nisha, Sunil Varughese, Jayamurthy Purushothaman, Sasidhar B.Somappa. Bioorganic Chemistry, 2020, 105, 104375.
  • NHC-Pd complex heterogenized on graphene oxide for cross-coupling reactions and supercapacitor applications. Vishal Kandathil, Aisha Siddiqa, Abhinandan Patra, Bhakti Kulkarni, Manjunatha Kempasiddaiah, S. Sasidhar, Shivaputra A. Patil, Chandra Sekhar Rout, Siddappa A. Patil. Appl Organometal Chem. 2020, e5924.
  • Hexagonal boron nitride supported N-heterocyclic carbene-palladium(II): A new, efficient and recyclable heterogeneous catalyst for Suzuki-Miyaura cross-coupling reaction. Arnet Maria Antony, Vishal Kandathil, Manjunatha Kempasiddaiah, S. Sasidhar, Shivaputra A. Patil & Siddappa A. Patil. Catalysis Letters, 2020, https://doi.org/10.1007/s10562-020-03401-x.
  • Rapid Visual Detection of Amines by Pyrylium Salts for Food Spoilage Taggant.
    Basavaraja D, Dibyendu Dey, Varsha T L, Chettiyan Thodi F. Salfeena, Manas K. Panda, Sasidhar B. Somappa. ACS Appl. Bio Mater. 2020, 3, 772?778.
  • I2/TBHP Mediated Diastereoselective Synthesis of Spiroaziridines. Kizhakkan Thiruthi Ashitha, Puthiya Purayil Vinaya, Ajay Krishna, Deepthy Cheeran Vincent, Renjitha Jalaja, Sunil Varughese, Sasidhar Balappa Somappa. Biomol. Chem., 2020, 18, 1588.
  • Immobilizing biogenically synthesized palladium nanoparticles on cellulose support as a green and sustainable dip catalyst for cross-coupling reaction. Manjunatha Kempasiddaiah, Vishal Kandathil, Ramesh B. Dateer, S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Cellulose, 2020, 27, 3335-3357.
  • DNA as a Bioligand Supported on Magnetite for Grafting Palladium Nanoparticles for Cross-Coupling Reaction. Vishal Kandathil, Manjunatha Kempasiddaiah, Sanna Kotrappanavar Nataraj, Sasidhar Balappa Somappa, Siddappa A. Patil. Appl Organometal Chem. 2020, e5357.
  • Immobilized N-heterocyclic carbene-palladium(II) complex on graphene oxide as efficient and recyclable catalyst for Suzuki-Miyaura cross-coupling and reduction of nitroarenes. Vishal Kandathil, Bhakti Kulkarni, Aisha Siddiqa, Manjunatha Kempasiddaiah, Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Catalysis Letters, 2020, 150:384-403.

2019

  • Magnetite tethered mesoionic carbene?palladium (II): Anefficient and reusable nanomagnetic catalyst for Suzuki?Miyaura and Mizoroki?Heck cross?coupling reactions inaqueous medium. Manjunatha Kempasiddhaiah, Vishal Kandathil, Ramesh B. Dateer, Balappa Sasidhar, Shivaputra A. Patil, Siddappa A. Patil. Appl Organometal Chem. 2019, e4846.
  • From Agriculture Residue to Catalyst Support; A Green and Sustainable Cellulose-Based Dip Catalyst for C-C Coupling and Direct Arylation. Vishal Kandathil, Manjunatha Kempasiddaiah, Sasidhar B. S., Siddappa A. Patil. Carbohydrate Polymers. 2019, 223, 115060.

2018

  • Synthesis of symmetrical and unsymmetrical triarylpyrylium ions by inverse electron demand Diels-Alder reaction.  C. T. Fathimath Salfeena, Basavaraja, K. T. Ashitha, V. Praveen Kumar, Sunil Varughese, Cherumuttathu H. Suresh and  B. S. Sasidhar. Chemical Communications, 2018, 54, 12463-12466.
  • Synthesis of 1,2,4-Trisubstituted-(1H)-Imidazoles Through Cu(OTf)2/I2 Catalyzed C-C Bond Cleavage of Chalcones and Benzylamines. Fathimath Salfeena, Chettiyan Thodi; Jalaja, Renjitha; Davis, Rincy; Suresh, Eringathodi; Somappa Sasidhar. ACS Omega, 2018, 3 (7), 8074-8082
  • Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors.  Renjitha Jalaja, Shyni Gangadharan Leela, Praveen Kumar Valmiki, Chettiyan Thodi F Salfeena, Kizhakkan T Ashitha, Venkata Rao D Krishna Rao, Mangalam S Nair, Raghu Kozhiparambil Gopalan, and Sasidhar Balappa Somappa. ACS Med. Chem. Lett., 2018, 9 (7), 662-666.
  • Phytochemical composition of Caesalpinia crista extract as potential source for inhibiting cholinesterase and ?-amyloid aggregation: Significance to Alzheimer’s disease. Kolambe Rajappa Chethana, Balappa Somappa Sasidhar, Mahadeva Naika,  Rangappa Sangappa Keri. Asian Pacific Journal of Tropical Biomedicine, 2018, 8(10), 500-512.
  • Biological evaluation of indole appended triazolothiadiazepine conjugates as potent anticancer agents. Kizhakkan T. Ashitha , Chettiyan T.F. Salfeena, Jalaja Renjitha, Valmiki P. Kumar, Rajesab Parveen, Balappa S. Sasidhar. Current Bioactive Compounds, 2018, 14 (4), 445-450.
  • Functionalized Pyrimidines from Alkynes and Nitriles: Application towards the Synthesis of Marine Natural Product Meridianin Analogs.  Banyangala Mohan, Chettiyan Thodi F. Salfeena, Kizhakkan T. Ashitha, Gopika V. Krishnan, Abdul Rasheed S. Jesmina, Angela M. Varghese, Siddappa A. Patil, Bhaskaran Nair S. Dileep Kumar, Balappa S. Sasidhar.  ChemistrySelect, 2018, 3, 6394 - 6398.
  • Green synthesis of palladium nanoparticles: Applications in aryl halide cyanation and Hiyama cross-coupling reaction under ligand free conditions.  Vishal Kandathil, Ramesh B. Dateer, B. S. Sasidhar, S. A. Patil, Siddappa A. Patil. Catalysis Letters, 2018, 148, 1562-1578.
  • Magnetic nanoparticle tethered Schiff base-palladium(II): highly active and reusable heterogeneous catalyst for Suzuki-Miyaura cross-coupling and reduction of nitroarenes in aqueous medium at room temperature. K. Manjunatha, Tuhin S. Kole, Vishal Kandathil, Ramesh B. Dateer, Geetha Balakrishna, B. S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil.   Appl Organometal Chem. 2018, 32, e4266.
  • An Uncommon Multicomponent Reaction Involving Nucleophilic Heterocyclic carbenes: Facile Synthesis of Fully Substituted Cyclopentanones.   Nair, Vijay; Krishnan, Jagadeesh; Jose, Anu; S, Sasidhar; Suresh, Eringathodi; S. Menon, Rajeev.  Organic Chemistry Frontiers, 2018, 5, 1202-1208.
  • A new magnetically recyclable heterogeneous palladium(II) as a green catalyst for Suzuki-Miyaura cross-coupling and reduction of nitroarenes in aqueous medium at room temperature.   Vishal Kandathil, Tuhin S. Koley, K. Manjunatha, Ramesh B. Dateer, Rangappa S. Keri,   B. S. Sasidhar, Shivaputra A. Patil, Siddappa A. Patil.   Inorganica Chimica Acta, 478 (2018) 195-210

2017

  • BF3•OEt2 Mediated Tandem Annulation: A Strategy to Construct Functionalized Chromeno-, and Pyrano- Fused Pyridines. Ashitha K. T,  Praveen Kumar V,  Fathimath Salfeena C. T,  B. S. Sasidhar. Journal of Organic Chemistry, 2018, 83, 113-124.
  • Epoxyazadiradione purified from the Azadirachtaindica seed induced mitochondrial apoptosis and inhibition of NF-B nuclear translocation in human cervical cancer cells. Shilpa G., Renjitha J., Saranga R., Sajin Francis K., Mangalam S. Nair, Beena Joy, B. S. Sasidhar and Priya S. Phytotherapy Research, 2017, 31, 1892-1902.
  • An overview of benzo [b] thiophene based medicinal chemistry. Rangappa S. Keri, Karam Chand, Srinivasa Budagumpi, B. S. Sasidhar, Siddappa A. Patil and Bhari Mallanna Nagaraj. European Journal of Medicinal Chemistry, 2017, 138, 1002-1033.
  • Biological evaluation of indole appended triazolothiadiazepine conjugates as potent anticancer agents. Kizhakkan T. Ashitha, C.T. Fathimath. Salfeena, Jalaja Renjitha, Valmiki P. Kumar, Rajesab Parveen and B. S. Sasidhar. Current Bioactive Compounds, 2017, DOI: 10.2174/1573407213666170707150757.
  • A Convenient, Efficient and Reusable N-Heterocyclic Carbene-Palladium(II) Based Catalyst Supported on Magnetite for Suzuki-Miyaura and Mizoroki-Heck Cross-Coupling Reactions. Siddappa A Patil, Vishal Kandathil, Bradley Fahlman, B. S. Sasidhar and S. Patil. New Journal of Chemistry, 2017, 41, 9531-9545.
  • Antibacterial and anti-tubercular evaluation of Dihydronaphthalenone-indole hybrid analogues. Praveen Kumar. V, Fathimath Salfeena. C.T, Ashitha. K.T, Sunil Varughese and B. S. Sasidhar. Chem Biol Drug Des, 2017, 90, 703-708.
  • Novel NHC-mediated synthesis of pyrrolo[2,1-a]isoquinolines and their photophysical investigations. Vijay Nair, Jagadeesh Krishnan, BalaramanVedhanarayanan, B. S. Sasidhar and Sunil Varughese. Chemistry-An Asian Journal, 2017, 12(6), 623-627.
  • Magnetic Nanoparticle-Supported N-Heterocyclic Carbene-Palladium (II): A Convenient, Efficient and Recyclable Catalyst for Suzuki-Miyaura Cross-Coupling Reactions. Vishal K, Bradley D. Fahlman, B. S. Sasidhar, S. A. Patil and Siddappa A. Patil. Catalysis Letters, 2017, 147,900-918.

2016

  • BF3•Et2O mediated one-step synthesis of N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines. C. T. Fathimath Salfeena, K. T. Ashithaa, and B. S. Sasidhar. Organic & Biomolecular Chemistry, 2016, 14, 10165-10169.
  • Sequential NHC-Catalyzed Reaction of Enals and Cyclic Aryldiene-1,3-Diones: Synthesis of Tricyclic Chromenones and Related Compounds. Jagadeesh Krishnan, Sneha Mathew, P. Anjana Jayaprakash, B. S. Sasidhar, T. S. Mayadevi, E. Suresh and Vijay Nair. Asian Journal of Organic Chemistry, 2016, 5(12), 1447-1451.
  • Synthesis of novel Indolylbenzo[b][1,4] diazepins as a potent antimicrobial and antioxidant agents. J. S. Biradar and B. S. Sasidhar. Arabian J Chem, 2016, 9, S1063-S1068.

2015

  • Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents. Rangappa S. Keri, Siddappa A. Patil and B. S. Sasidhar. European Journal of Medicinal Chemistry, 2015, 100, 257-269.
  • Lewis Acid Catalyzed C-3 Alkylidene cyclopentenylation of Indoles: An Easy Access to Functionalized Indoles and Bisindoles. Sarath Chand S., B. S. Sasidhar, Praveen Prakash, Sasikumar P., Preethanuj P., Florian Jaroschik, Dominique Harakat, Jean-Luc Vasse and Radhakrishnan K. V. RSC advances, 2015, 5, 38075.
  • One-pot synthesis of indole appended heterocycles as potent anti-inflammatory, analgesic, and CNS depressant agents. B. S. Sasidhar, Jaiprakash SharnappaBiradar, ParveenRajesab, Shaik Rahber and MetySundar. Monatshefte fur Chemie, 2015, 146(12),2067-2078.

2014

  • Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho functionalized aryl iodides and aliphatic alcohols. S. Sarath Chand, S. Saranya, P. Preethanuj, B. P. Dhanya, E. Jijy, Praveen Prakash, B. S. Sasidhar, Jan Szymoniak, P. V. Santhini, and K. V. Radhakrishnan. Organic & Biomolecular Chemistry, 2014, 12(19), 3045-61.
  • Design and synthesis of novel thiopheno-4-thiazolidinylindoles as potent antioxidant and antimicrobial agents. Jaiprakash. S. Biradar, Rajesab Parveen and B. S. Sasidhar. Chemical Papers, 2014, 68 (3), 392-400.
  • Microwave assisted Synthesis of Novel Imidazolopyridinyl indoles as Potent Antioxidant and Antimicrobial Agents. Jaiprakash S. Biradar, Parveen Rajesab, and B. S. Sasidhar. Journal of Chemistry, 2014, Doi.org/10.1155/2014/579612.

2013

  • A Mini Library of Novel Indolyl triazolo thiadiazepines: Synthesis, Antioxidant and Antimicrobial Evaluations. Jaiprakash. S. Biradar, Rajesab Parveen, Naveen B. and B. S. Sasidhar. The Scientific World Journal, 2013, Doi.org/10.1155/2014/581737.
  • Synthesis of some bisindolyl analogs for in vitro cytotoxic and DNA cleavage studies. B. S. Sasidhar and J. S. Biradar. Med Chem Res, 2013, 22, 3518-3526.

2012- 2008

  • Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation. J. S. Biradar and B. S. Sasidhar. Eur J Med Chem, 2011, 46, 6112-6118.
  • Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives. J. S. Biradar, B. S. Sasidhar and R. Parveen. Eur J Med Chem, 2010, 45, 4074-4078.
  • Synthesis of new indolylbenzodiazepins and their DNA cleavage and antimicrobial activities. J. S. Biradar, R. Parveen, B. S. Sasidhar and S. M. Praveen. Ind J Het Chem, 2010, 20, 181-182.
  • A versatile one-pot synthesis of novel substituted pyrazoles, isaxazoles and their antimicrobial activity. J. S. Biradar, B. S. Sasidhar, S. M. Praveen and B. Sharanbasappa. Organic Chemistry, 2009, 5(3), 262-265.
  • Improved synthesis of some pyrazolines under microwave. J. S. Biradar, Praveen. S. Mugali, B. Sharanabasappa and B. S. Sasidhar. Ind J Het Chem, 2008, 18, 141-144.
  • One pot synthesis of substituted imidazoles containing indole and their antimicrobial activities. Jaiprakash. S. Biradar, Praveen. S. Mugali, B. S. Sasidhar and Parveen. Rajesab. Organic Chemistry, 2008, 4(6-8), 408-411.
  • Synthesis ofnovel 2, 5-disubstituted-3[3’-(pyridine-2”-yl)-1’-substituted pyrazole-5’-yl and isoxazol-5’-yl]-1H-indole in triethyl amine medium. J. S. Biradar, B. Sharanbasappa, S. M. Praveen and B. S. Sasidhar. Organic Chemistry, 2008, 4(4), 266-268.
Alumni
Sangeetha Dr Sangeetha Mohan
(2019 to 2025)
Athira Athira C. S.
(2019 to 2025)
Praveen Dr Praveen Kumar Valmiki
(2016 to 2024)
Basavaraja Dr Basavaraja D
(2017 to 2023)
Ashitha Dr Ashitha K T
(2016 to 2022)
Renjitha Dr Renjitha J
(2016 to 2022)
Fathima Dr. Fathimath Salfeena C. T.
(2014 to 2018)
Jagadeesh Dr. Jagadeesh Krishnan
(2014 to 2018)

 

Group
Anjali Anjali S
PhD Student ( UGC - SRF)
Email id: anjalisept94[at]gmail.com
Siddalingeshwar Siddalingheshwar V Doddamani
PhD Student ( CSIR - SRF)
Email id: siddudmn94[at]gmail.com
Nithya Nithya M
PhD Student ( UGC - SRF)
Email id: nithyamadhu2010[at]gmail.com
Mohan Mohan B
PhD Student
Email id: mohanbsdm9[at]gmail.com
Ajay Ajay Krishna M.S
PhD Student
Email id: ajaykrishnamurali[at]gmail.com
Aiswarya Aiswarya Siby
Project Associate
Email id: aisupasi98[at]gmail.com
Sreelakshmi Sreelakshmi V
Project Associate
Email id: sreelakshmi99v[at]gmail.com
Alan Sheeja Dr. Alan Sheeja
DST - TARE FELLOW
Ancy Ancy A
Ph.D. Student (UGC-SRF)
Email id: ancyasee[at]gmail.com
Aparna Aparna H R
Ph.D. Student (UGC-SRF)
Email id: aparnaharikumar2000[at]gmail.com
Lal Lal Shikanther Basha
Project Associate
Email id: shikantherbasha917[at]gmail.com
Karthik Karthik K S
Project Associate
Email id: karthikks.no1[at]gmail.com
Geetu Geethukrishna P V
Project Associate
Email id: geethukrishna2000[at]gmail.com
Research Interest

Research Interest

Dr. Sasidhar’s group is focused on the interdisciplinary aspects of chemistry with respect to medicinal and material properties. This includes methodology, target-oriented synthesis, medicinal chemistry (Drug-like molecules), Green-chemistry, and phytochemistry. The focused activity of the group on fundamental aspects of organic and medicinal chemistry has led to the successful translational.

  • Drug discovery for metabolic disorders (Obesity, Diabetes, Cardiovascular, etc.).
  • Small molecule-based innovative approaches for the discovery of potent Leads against infectious diseases (Antimicrobials and Antivirals).
  • Small molecule-based Multi-Target-Directed-Ligands and PROTACS as Ant-Alzheimer Agents.
  • Phytopharmaceutical Leads against diverse targets.
  • Fluorescent probes for imaging, biomedical diagnosis, security & sensing, and taggants.
Conference Presentations

Conference Presentations

  • Natural product derived triazole hybrids as potent pancreatic lipase inhibitors. Renjitha J and Sasidhar B. S, 32nd Kerala Science Congress, Yuvakshetra Institute of Management Studies, Mundoor, Palakkad, 25-27th January 2020.
  • I2/TBHP Mediated Diastereoselective Synthesis of Spiroaziridines.
    Ashitha K. T., Sasidhar B. S., 32nd Kerala Science Congress, Yuvakshetra Institute of Management Studies, Mundoor, Palakkad,  25-27th January 2020.
  • Nitriles: A Valuable Synthons in Nitrogen Containing-Heterocyclic and Building Block Synthesis. Ashitha K. T., Sasidhar B. S., CSIR- Inter Institutional Students Conference on Sustainable Chemistry for Heath, Environment and Materials (Su-CHEM Yuva 2019) at CSIR-Indian Institute of Chemical Technology, Hyderabad, during July 24th to 26th 2019.
  • Natural product derived triazole hybrids as potent pancreatic lipase inhibitors. Renjitha J, Shyni G. L, Raghu K. G and Sasidhar B. S, Current Trends in Drug Discovery Research (CTDDR-2019) at CSIR-CDRI, Lucknow, Uttar Pradesh, India. 20-23 February, 2019
  • Antibacterial evaluation of (E)-labda-8,(17),12-diene-15,16-dial isolated from the edible ginger Curcuma amada and its semisynthetic derivatives. Renjitha J, Dileep Kumar B. S and Sasidhar B. S, International seminar on Phytochemistry (ISP-2018) organized by Kerala academy of Sciences & Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Palode, India. 26-27 March, 2018
  • BF3•OEt2 Mediated Tandem Annulation: A Strategy To Construct Functionalized Chromeno- and Pyrano-Fused Pyridines. Ashitha K.T. and Sasidhar B. S., XIV J-NOST Conference for Research Scholars organized at CSIR-Indian Institute of Chemical Technology, Hyderabad, during 28th November to 1st December, 2018.
  • Multicomponent strategy for the synthesis of N-substituted-1,2Dihydropyridines; Water acts as a reactant. Fathimath Salfeena C. T, Ashitha K. T, Sasidhar B. S., Poster presentation at CRSI NSC-21 National symposium, July 14-16, 2017, IICT-Hyderabad, India.
  • Isolation and synthetic modification of Bioactive from Nutraceutically important Curcuma amada.. J. Renjithaa, V. Praveen Kumar, Jubi Jacoba, Mangalam S. Nair, B. S. Dileep Kumar and B. S. Sasidhar., Poster presentation; at International Conference on Nutraceutical & Chronic Diseases, Sep 1-3, 2017, Goa, India.
  • Epoxy Azadiradione isolated from the Azadirachta Indica induced Mitochondrial mediated apoptosis in Hela cells. Shilpa G, Renjitha J, Sarang R, Sajin F, Mangalam S Nair, Sasidhar B S, Priya S, Oral Presentation; at International Conference on Nutraceutical & Chronic Diseases, Sep 9-11, 2016, Cochin, Kerala, India.
  • “Synthesis of Novel Substituted-3-imidazolyl indoles and their biological activities” Praveen. S. Mugali,Sharanabasappa B,Parveen R, Sasidhar. B. S. and J. S. Biradar*, at 26th Annualconference of Indian Council of Chemists, Department of Chemistry, Dr. H. S. Gour University, 25-27 December, 2007.
  • “Synthesis of novel diazepinylindoles and their Biological evaluation”,Parveen R, Praveen S. Mugali, Sharanabasappa B.Sasidhar. B. S. and J. S. Biradar*, at 26th Annual conference of Indian Council of Chemists, Department of Chemistry, Dr. H. S. Gour University, Sagar, 25-27 December, 2007.
  • “Synthesis of novel 2,5,- disubstituted-3[3’-(pyridine 2”-yl)-1’-substituted Pyrazol-5’-yl and isoxazol-5’-yl]-1H-indole in Triethylamine medium”,B.Sharanbasappa, Praveen.S.mugali andSasidhar. B.S and J.S.Biradar. At the International Conference on Drug Discovery and Nanotechnology, Department of Chemistry, YeshwantMahavidyalaya, Nanded, Maharashtra, India, January 27th -29th , 2008.
  • “One-pot synthesis of novel substituted pyrazoles and isaxazoles and their antimicrobial activity”, B. S. Sasidhar, Veena. R, Parveen. R., At Indian chemical societies 45th Annual Convention of Chemists and International Conference on Recent Advances in Chemistry, Department of studies in chemistry, Karnatak University, Dharwad, Karnataka, India, November 23-27, 2008.
  • “Synthesis and biological activities of 5-((e)-3-(2,5-disubstituted 1h-indol-3-yl)-(4- substituted phenyl) allylidene) pyrimidine 2,4,6(1h,3h,5h)-trione”B. S. Sasidhar, Parveen. R and J. S. Biradar, at the MEDCHEM 2009, Conference cum Workshop on Current Trends in Medicinal Chemistry, Department of Chemistry, Indisan Institute of Technology Madras, India, April 2-4, 2009.
  • “Synthesis and Biological Evaluation of Novel Substituted Pyrazoles, Isoxazoles and Pyrimidines”,B.S.Sasidhar, B. Sharanabasappa, Parveen R, & J. S. Biradar, at the NACEAC-2009, National Conference on the Emerging Areas in Chemistry. Department of Chemistry, University of Mysore, Mysore, Karnataka, India, on 31-07-2009 and 01-08-2009.
  • “Synthesis and Biological Activities of Some Novel Mannich Bases from Indole-3-carboxaldehydes”, B.S.Sasidhar, Sujatha.R& J. S. Biradar, at the NACEAC-2009, National Conference on the Emerging Areas in Chemistry. Department of Chemistry, University of Mysore, Mysore, Karnataka, India, on 31-07-2009 and 01-08-2009.
  • “Synthesis of Novel IndolylImidazoles and Their Biological Activities”Parveen R, B.S.Sasidhar,B. Sharanabasappa, & J. S. Biradar, at the ICCTCB-2009, Held at the Department of Chemistry, Central College Campus, Bangalore University, Bangalore, on 18-12-2009 and 19-12-2009, Bangalore, Karnataka, India.
  • “A one - pot, three components, solvent free, conventional and Microwave synthesis of novel indole analogues bearing 1H-pyrazol-5(4H)-one as a potent antioxidant agents”.B. S. Sasidhar and J. S. Biradar, at two days National Symposium on Frontier Areas in Chemical Science and Nanotechnology, held at Kuvempu University, during May 1-2, 2010.
  • “A conventional and Microwave synthesis of novel pyrimidinyl and thiazolidinyl indole analogues as a potent anticancer agents”B. S. Sasidhar, Parveen. Rand J. S. Biradar, in the Young Scientists Oral Presentation Category, at the 47th Annual Convention of Chemists - 2010 and International Conference on Recent Advances in Chemical Sciences, School of Studies in Chemistry, Pt. RavishankarShukla University, Raipur, Chattisgarh.
  • “A one-pot, three component, solvent- and catalyst-free Michael addition of indoles and their biological evaluation”B. S. Sasidhar, Parveen. R, S. Rahberand J. S. Biradar, in the Young Scientists Oral Presentation Category, at the ICSSC-2011, Department of Chemistry, Mangalore University, Mangalore, India, 08th-10th Dec-2011.
  • “A novel one pot synthesis of (2,5-dichlorothiophen-3-yl)-Pyrazol / Isoxazol / Pyrimidine Indole analogues as a potent Antioxidant and Anticancer agents” B. S. Sasidhar, Parveen. R, Rahaber. Sand J. S. Biradar, in the Young Scientists Oral Presentation Category (Organic Chemistry), at the 30th Annual Conference of Indian Council of Chemists, Department of Chemistry, Osmania University, Hyderabad,india, 28th-30th Dec-2011.
 
Projects

Details of Ongoing Research Projects

  • Base Controlled Diversity Synthesis of Spiro-Indolinone Hybrids of Medicinal Relevance -DST-SERB, Govt. of India, Principal Investigator.
  • Development of Antihyperlipidemic Phytopharmaceutical lead from Curcuma Amada (Zinger Health), Phytopharmaceutical Mission Project, CSIR, Govt. of India, Phase III- Principal Investigator.
  • Rational Design of Antimicrobials Targeting Bacterial Membrane to Combat Multidrug Resistance, The Indian Council of Medical Research (ICMR), Govt. of India, Co-Principal Investigator.
  • Isolation and Exploration of Phytochemicals Against Obesity and Related Complications - KSCSTE, Govt. of Kerala, Principal Investigator.
  • Bioactivity-Guided Isolation and Identification of Anti-Inflammatory and Antidiabetic Agents from Selected Medicinal Plants - DST-SERB, Govt. of India, Mentor/ Principal Investigator.
  • Sustainable utilisation of regional biodiversity for the identification of value-added chemical intermediates and phytopharmaceuticals- CSIR, Govt. of India, Principal Investigator.
  • Sustainable Packaging Mission, Antimicrobial Coatings, CSIR, Govt. of India, Co-Principal Investigator.
  • Bioresource Conservation and Prospection, CSIR, Govt. of India, CSIR Mission Project, Co-Principal Investigator.
  • Clinical validation of traditional millet recipes in maintaining healthy intestinal microbial flora and preventing lifestyle-associated complications. ANRF, Govt. of India, Co-Principal Investigator.

Details of Completed Research Projects

  • Nature-Inspired Chemical Entities for Healthcare Applications (NICE-HEALTH)- DST-SERB - Principal Investigator.
  • Development of mitochondrial anti-oxidants for geriatric well-being- CSIR- Principal Investigator.
  • Trapping glycation intermediates for the modulation of diabetes and its complications: A natural product-derived therapeutic approach - CSIR-Co-Principal Investigator.
  • Process development for the Nitazoxanide drug - CSIR- Principal Investigator.
  • Development of commercially viable synthetic plant growth and soil fertility improvement compounds and their exploitation in agriculture - CSIR- Principal Investigator.
  • Agro mission- Crop protection chemicals, CSIR, Govt. of India, Phase II- Co-Principal Investigator.
  • CSIR: Discovery & Pre-clinical Development of Antivirals for COVID-19 & other diseases - CSIR, Govt. of India, Phase II- Co-Principal Investigator.
  • Development of Knowledge Base on Pharmaceutical Formulations - KSDPL- Co-Principal Investigator.
  • Agro mission- Crop protection chemicals - Phase I- Principal Investigator
  • Biostimulants for stress amelioration, enhanced plant productivity and soil health - CSIR-Co-Principal Investigator.
  • Synthesis of a library of Aza-C-KRN7000 and Aza-galactolipid analogues for
  • Organic Reactions In Generating Innovative and Novel Scaffolds (ORIGIN) - CSIR- Co-Principal Investigator.
  • Natural Products as Affordable Healthcare Agents (NaPAHA) - CSIR- Co-Principal Investigator.
  • SABIC Industries Collaborative Project - Co-Principal Investigator.
Patents

Patents

  • An Improved Process for the Preparation of Nitazoxanide and Intermediates Thereof. Appl no: PCT/IN2022/050843, date of filing: 21-09-2022. WO patent
  • Pyrazole amide-based compounds and uses against Breast Cancer thereof. Appl no: 202111052657, date of filing: 16-11-2021. Indian patent.
  • Pyrazole amide-based compounds and uses against Breast Cancer thereof. Appl no: PCT/IN2022/051006, date of filing: 16-11-2022. WO patent.
  • Process for the preparation of pyrylium salts. Grant no: 466604, date: 07-11-2023. Indian patent.
  • Process for the preparation of pyrylium salts. Appl no: 18904834.1, date of filing: 03-08-2020. European patent
  • Process for the preparation of pyrylium salts. Grant no: 7337818, date: 25-08-2023. Japanese patent
  • Process for the preparation of pyrylium salts. Grant no: 1.2E+07, date: 30-05-2023. US patent
  • An Improved Process for the Preparation of Nitazoxanide and Intermediates Thereof. Appl no: 202111045217, date of filing: 05-10-2021. Indian patent.
  • Preparation of 5-nitrothiazol-2-yl nicotinamide derivatives and uses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) thereof. Under filing.
  • Synthesis of Phthalimide Derivatives and Application Against Alzheimer’s Disease (AD) thereof. Under filing.
  • Preparation of Phytopharmaceutical formulation for the Lipid control and associated complications, and methods thereof. Under filing.