Highlights

Harnessing the natural wealth (plant/herbal) of the region to obtain novel biologically active compounds or leads for drug synthesis, exploring traditional systems of medicine including Ayurveda, Siddha and tribal medicine for lead structures and correlating/corroborating this wealth of knowledge with modern diagnostic chemical and biological testing methods. Under natural products program specific attention is given to the discovery of antioxidants, antiobesity, antidiabetic, antiviral, anti-inflammatory agents and anticancer compounds. Natural products are also synthetically modified and studied for the changes/enhancement in biological activities. We are also creating a library of phytochemical markers/standards to support the quality control/standardization of herbal raw materials and finished products. We are also strengthening our capability to develop technically and commercially suitable galenical formulations of traditional medicines.

• Natural Products Chemistry

Design and synthesis of bioactive molecules which includes small molecule-based antimicrobials, heterocycle based anticancer agents, neoglycoconjugates, nucleoside phosphonates as antivirals & synthetic plant growth promoters for improved crop productivity and soil fertility.

• Synthesis of Bioactive Molecules

The central theme of organic synthesis is making and breaking of bonds in a selective and controlled fashion by focusing on reactive intermediates like cation and anion radicals, carbenes/carbenoids, ylides, dipoles etc. We employ pericyclic, chemical electron transfer, tin mediated radical cyclization reactions, multicomponent reactions, organo-and metal-catalyzed reactions in the above program. Several transformations based on these ideas have been developed.

• Development of Novel Reactions/Reagents

Our research focuses on developing materials with unique fluorescent and mechanical properties and drawing structure-property correlations to comprehend the underlying molecular arrangements that contribute to the crystal property. We use crystal engineering strategies to develop solid forms of active pharmaceutical ingredients (APIs) with enhanced activity and optimal plasticity to attain better tabletability.

• Solid State and Supramolecular Structural Chemistry

Research in Green chemical techniques on account of the future needs of advanced Chemical Technologies to be economical, safe, environmentally benign as well as resource and energy saving. In this line, we also design and fabricate heterogeneous catalysts (with high TON & TOF) from cheap and easily available materials like clay/magnesium phyllosilicate for organic transformations. Research Highlights Events Currently no data available Moments of Workshop Publications Address CSIR – National Institute for Interdisciplinary Science and Technology (NIIST) Council of Scientific and Industrial Research (CSIR) Ministry of Science and Technology, Government of India Industrial Estate PO, Thiruvananthapuram, India Quick Links CSIR Services Scientific Profile Patents Technologies Publications Awards Events Visiting NIIST Reaching NIIST Recreation Club Student Club Guest House Alumni Directory Academic Programme CSIR Jigyasa programme CSIR Map Digital India Analytical facilities Research Facilities

• Green Chemical Techniques and Catalysts

Research in Green chemical techniques on account of the future needs of advanced Chemical Technologies to be economical, safe, environmentally benign as well as resource and energy saving. In this line, we also design and fabricate heterogeneous catalysts (with high TON & TOF) from cheap and easily available materials like clay/magnesium phyllosilicate for organic transformations.