Dr. P Jayamurthy
- Dr. P Jayamurthy
- Senior Principal Scientist
- pjayamurthy@niist.res.in
- 0471-2515347
- +919746459990
PERSONAL INFORMATION
Dr. P. Jayamurthy completed his Master of Science in Biochemistry from Bharathidasan University, Trichy in 2002. He obtained his Ph.D. in Biochemistry from the Defence Institute of Physiology & Allied Sciences (DRDO, Delhi) under Bharathiar University, Coimbatore in 2009. He joined CSIR-NIIST, Thiruvananthapuram in November 2007 as Junior Scientist in the Agro Food Processing and Technology Division. Since November 2024, he has been serving as Senior Principal Scientist at CSIR-NIIST, Thiruvananthapuram. He is also associated with the Academy of Scientific & Innovative Research (AcSIR) as Associate Professor in Biological Sciences and AcSIR Coordinator at CSIR- NIIST. His major research areas include nutraceuticals and phytopharmaceuticals, metabolic disorders, glycation, ER stress, oxidative stress, and inflammation. He has supervised 15 M.Sc. students, 6 Ph.D. scholars and 3 post-doctoral fellows under his guidance. He has published over 45 research papers in reputed journals, with more than 2200 citations, an h-index of 25, and an i10-index of 32. He has successfully led and collaborated on several funded projects from CSIR, DBT, DST, KSCSTE, and industry, focusing on natural product-based therapeutics, diabetes management, biosensing applications, and development of evidence-based nutraceuticals. His research contributions include the bio- prospecting of medicinal plants, trapping of glycation intermediates to modulate diabetes complications, validation of natural products such as virgin coconut oil, and development of herbal formulations for preventive health and disease management.
- 2024 – Present: Senior Principal Scientist, CSIR-NIIST, Thiruvananthapuram, India
- 2019 – 2024: Principal Scientist, CSIR-NIIST, Thiruvananthapuram, India
- 2015 – 2019: Senior Scientist, CSIR-NIIST, Thiruvananthapuram, India
- 2010 – 2015: Scientist, CSIR-NIIST, Thiruvananthapuram, India
- 2007 – 2010: Junior Scientist, CSIR-NIIST, Thiruvananthapuram, India
Focus
- PHYTOCHEMICALS AND NUTRACEUTICAL DEVELOPMENT FOR METABOLIC WELLNESS
- ANTI-DIABETIC VALIDATION
- ER STRESS & OXIDATIVE STRESS, INFLAMMATION CONTROL
- MOLECULAR NUTRITION AND NATURAL PRODUCT THERAPEUTICS
- INNOVATIVE APPROACHES TO GLYCATION MODULATION AND INSULIN SENSITIZATION
I. Nutraceutical and Phytopharmaceutical Development
• Identification and bio-prospecting of anti-diabetic medicinal plants
• Development of natural product–based therapeutic leads
II. Mechanistic Studies in Metabolic Disorders
• Investigations on protein glycation, ER stress, oxidative stress, inflammation
• Pathway elucidation for glucose uptake, insulin secretion and AMPK activation
III. In Vitro and In Vivo Evaluation
• Biochemical assays, cell line models (L6 myotubes, pancreatic beta cells)
• Animal models for diabetes and related complications
IV. Product Development and Scientific Validation
• Development of evidence-based nutraceuticals and herbal formulations
• Industry-partnered validation (virgin coconut oil, plant extracts)
V. Biosensing and Analytical Tool Development
• Fluorescent probes for detecting glycation intermediates and biomarkers
- PhD Defence Institute of Physiology & Allied Sciences (DRDO, Delhi) under Bharathiar University, Coimbatore
- MSc in Biochemistry, Bharathidasan University, Trichy
- BSc in Biochemistry, University of Madras
Research Supervision
- Postdoctoral researcher (Past/current): 2
- Ph. D. Awarded: 2
- Ph. D. Ongoing : 3
- Project Assistants (Past/Current): 8
- M. Sc. Students: 10
Undertake translational research focusing on natural products, nutraceuticals, and phytopharmaceuticals for the
prevention and management of metabolic disorders, with emphasis on food-based therapeutic interventions and
functional health solutions.
- Development of nutraceuticals and phytopharmaceuticals from natural and agri-food sources
- Mechanistic studies on metabolic disorders including diabetes, obesity, and related complications
- Glycation biology: trapping of glycation intermediates and prevention of advanced glycation end- products(AGEs)
- Role of ER stress, oxidative stress, and inflammation in disease progression
- Natural product-based interventions for gut health, lipid metabolism, and immune modulation
- Functional food formulation and validation using bioactive compounds from plants
- Translational approaches for developing affordable herbal/nutraceutical products for public health
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Kerala State Young Scientist Award |
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Best paper award |
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Best paper award |
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Best poster award at International symposium on Phytochemicals,Trivandrum (2015) |
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Best Poster award at International conference on advances in degenerative diseases and molecular interventions (ADDMI-2017) |
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Best Poster award |
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PUBLICATIONS
1.Sobha, A.; Krishnan, L.; Shaik, S.; Pai, A.; Purushothaman, J.; Alaganandan, K.;Somappa, S. B.
Multi-Target Directed Triazole Derivatives: Design, Synthesis, and Evaluation of Synergistic
Modulation in Alzheimer’s Disease. (ACS Chemical Neuroscience - Manuscript ID cn-2025-
00602r
2. Sobha, A.; Krishnan, L.; Shaik, S.; Pai, A.; Purushothaman, J.; Alaganandam, K.; Somappa, S.
B. Targeting Alzheimer’s Pathology: Tetralone- and thiochromanone-based benzyl pyridinium
derivatives as promising multitarget-directed ligands. Bioorg. Med. Chem. 2025, 130,
118369. https://doi.org/10.1016/j.bmc.2025.118369.
3. Sangeetha Mohan, Lekshmy Krishnan, Nithya Madhusoodanan, Anjali Sobha, Alansheeja D
Babysulochana, Naveen Vankadari, Jayamurthy Purushothaman, Sasidhar B Somappa. Ligand-
Based Pharmacophoric Design and Anti-inflammatory Evaluation of Triazole Linked
Semisynthetic Labdane Conjugates. ACS Med Chem Lett. 2024 Jul 23;15(8):1260-1268. doi:
10.1021/acsmedchemlett.4c00141. eCollection 2024 Aug 8.
4. Abdul Rahim Muhammed Jasim, Beena Levakumar Abhirami, Eveline
Maria Anto, Sinumol George, Purushothaman Jayamurthy, Alaganandam Kumaran. Multimodal
therapeutic amelioration of type 2 diabetes via bioactive compounds isolated from Cassia
mimosoides L. South African Journal of Botany, Volume 172, September 2024, Pages 567-578
5. Prabha B, S Lekshmy Krishnan, Billu Abraham, P Jayamurthy, KV Radhakrishnan. An insight
into the mechanistic role of (-)-Ampelopsin F from Vatica chinensis L. in inducing insulin
secretion in pancreatic beta cells. Bioorg Med Chem. Volume 103, 1 April 2024, 117695.
6. Roopasree OJ, Soura C, Kozhiparambil GR, Jayamurthy P, Shobi V.. Joubert syndrome causing
mutation in C2 domain of CC2D2A affects structural integrity of cilia and cellular signaling
molecules. Exp Brain Res. 2024 Mar;242(3):619-637.
7. Sangeetha Mohan, Lekshmy Krishnan, Nithya Madhusoodanan, Anjali Sobha, Renjitha Jalaja,
Alaganandam Kumaran, Naveen Vankadari, Jayamurthy Purushothaman, Sasidhar B Somappa.
Linker-Based Pharmacophoric Design and Semisynthesis of Labdane Conjugates Active against
Multi-Faceted Inflammatory Targets. J Agric Food Chem. 2024 Mar 27;72(12):6389-6401. doi:
10.1021/acs.jafc.3c09536.
8. Nair Anaga, Krishnan Lekshmy, Jayamurthy Purushothaman. (+)-Catechin mitigates impairment
in insulin secretion and beta cell damage in methylglyoxal-induced pancreatic beta cells. Mol Biol
Rep. 2024 Mar 23;51(1):434. doi: 10.1007/s11033-024-09338-3.
9. Eveline MA, Jayamurthy P . Tangeretin enhances pancreatic beta-TC-6 function by ameliorating
tunicamycin-induced cellular perturbations. Mol Biol Rep. 2023 Dec 29;51(1):43
10. Eveline M Anto, C R Sruthi, Lekshmy Krishnan, K G Raghu, Jayamurthy Purushothaman.
Tangeretin alleviates Tunicamycin-induced endoplasmic reticulum stress and associated
complications in skeletal muscle cells. Cell Stress Chaperones. 2023. doi: 10.1007/s12192-023-
01322-3
11. Mohan K, Makebe CW, Jayamurthy P, Nisha P. Red palm oil Pickering emulsion with pectin
yields improved in vitro beta carotene bioaccessibility and oil stability: Physicochemical
characterization and shelf stability studies. Journal of Food Processing and Preservation,
e16930. doi.org/10.1111/jfpp.16930
12. Sony Udayan, Drishya Elizebath, D.R. Sherin, Vakayil K. Praveen, Sini Sunny, Purushothaman
Jayamurthy, T.K.Manoj kumar, V.P.N. Nampoori, Sheenu Thomas. Hexamethine hemicyanine
dye as a thermo-optical probe for serum albumin. Optics & Laser Technology. Vol
143, November 2021, 107351
13. B. Prabha, S. Sini, T. S. Priyadarshini, P. Sasikumar, Greeshma Gopalan, Jayesh P. Joseph, M.
M. Jithin, V. V. Sivan, P. Jayamurthy, and K. V. Radhakrishnan. Anti-inflammatory effect and
mechanism of action of ellagic acid-3,3′,4-trimethoxy-4′-O-α-L-rhamnopyranoside isolated
from Hopea parviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages. Natural
Product Research 2021, VOL. 35, NO. 18, 3156-3160
14. B. Prabha, S. Sini, D. R. Sherin, S. Neethu, K. B. Rameshkumar, T. K. Manoj
kumar, P. Jayamurthy, and K. V. Radhakrishnan. Promalabaricone B from Myristica fatua Houtt.
seeds demonstrate antidiabetic potential by modulating glucose uptake via the upregulation of
AMPK in L6 myotubes. Natural Product Research 2021, VOL. 35, NO. 5, 867-872.
15. Anaga N, Sunil V, Sasidhar BS, Jayamurthy et al,. Advanced glycation end-products (AGE)
trapping agents: Design and synthesis of nature inspired indeno[2,1-c]pyridinones. Bioorganic
Chemistry 2020, Dec;105:104375. doi: 10.1016/j.bioorg.2020.104375
16. Dhanya R., Jayamurthy P. In vitro evaluation of antidiabetic potential of hesperidin and its
aglycone hesperetin under oxidative stress in skeletal muscle cell line. Cell Biochem Funct.
2020;1–9.
17. Sasikumar P, Lekshmi K, Jayamurthy P, Radhakrishnan KV. Isolation and characterization of
resveratrol oligomers from the stem bark of Hopea ponga (Dennst.) Mabb. and their antidiabetic
effect by modulation of digestive enzymes, protein glycation and glucose uptake in L6 myocytes;
J Ethnopharmacol; 2019; May 23;236:196-204.
18. Jith C. Janardhanan, Rakesh K. Mishra, Gourab Das, Suresh Sini, Purushothaman Jayamurthy,
Cherumuttathu H. Suresh, Vakayil K. Praveen, Narayanapillai Manoj, Beneesh P. Babu.
Functionalizable 1H‐Indazoles by Palladium Catalyzed Aza‐Nenitzescu Reaction:
Pharmacophores to Donor‐Acceptor Type Multi‐Luminescent Fluorophores. Asian J. Org.
Chem. 2018, 7, 1–12
19. Prabha B, Neethu S, Krishnan SL, Sherin DR, Madhukrishnan M, Ananthakrishnan
R, Rameshkumar KB, Manojkumar TK, Jayamurthy P, Radhakrishnan KV. Antidiabetic potential
of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.)
Sinclair. Bioorg Med Chem. 2018 Jul 23;26(12):3461-3467. doi: 10.1016/j.bmc.2018.05.020
20. Syama H.P., T. Sithara, S. Lekshmy Krishnan, P. Jayamurthy. Syzygium cumini seed attenuates
LPS induced inflammatory response in murine macrophage cell line RAW264.7 through NF-κB
translocation. Journal of Functional Foods 44 (2018) 218–226
21. Syama H P, K B Arun, George Sl, R Dhanya, S S Anusree, P. Nisha, L R Shankar, A Sundaresan,
P Jayamurthy. Syzygium cumini seed exhibits antidiabetic potential via multiple pathways
involving inhibition of α‐glucosidase, DPP‐IV, glycation, and ameliorating glucose uptake in
L6 cell lines. Journal of food processing and preservation, (2018), 42 (2) DOI:
10.1111/jfpp.13464
22. Jamsheena V, R K. Mishra, K S. Veena, S Sini, P Jayamurthy, and Ravi S. L. New 1,2-
Dihydropyridine-Based Fluorophores and Their Applications as Fluorescent Probes. ACS Omega,
(2018), 3 (1), pp 856–862. DOI: 10.1021/acsomega.7b01835
23. Dhanya R, Arya Das, Nisha P And Jayamurthy P. Quercetin, a lead compound against type 2
diabetes ameliorates glucose uptake via AMPK pathway in skeletal muscle cell line. Front.
Pharmacol. 2017, doi: 10.3389/fphar.2017.00336
24. Syama H. P. , Arya A. D. , Dhanya R. , Nisha P. , Sundaresan A. , Jacob E. , Jayamurthy P. .
Quantification of phenolics in Syzygium cumini seed and their modulatory role on tertiary butyl-
hydrogen peroxide-induced oxidative stress in H9c2 cell lines and key enzymes in
cardioprotection. Journal of Food Science and Technology. J Food Sci Technol, 2017,
doi:10.1007/s13197-017-2651-3
25. Jubi J, Reshma UR, Syama H P, Jayamurthy P, Dileep Kumar B S. Enhanced antibacterial
metabolite production through the application of statistical methodologies by a Streptomyces
nogalater NIIST A30 isolated from Western Ghats forest Soil. PLoS One. Public Library of
Science; 2017; 4
26. Syama H P, Nisha P, and Jayamurthy P. Antioxidant activity, phenolic-flavonoid content and high-
performance liquid chromatography profiling of three different variants of Syzygium cumini
seeds: A comparative study. J Intercult Ethnopharmacol. 2017 Jan-Mar; 6(1): 107–114.
27. Arun K. B., P. Jayamurthy, C. V. Anusha, S. K. Mahesh and P. Nisha. Studies on activity guided
fractionation of pomegranate peel extracts and its effect on antidiabetic and cardiovascular
protection properties. Journal of Food Processing and Preservation; 2016;
Doi:10.1111/Jfpp.13108
28. Anees P, Karivachery V. Sudheesh, P Jayamurthy, Arunkumar R. C, R V. Omkumar and A
Ajayaghosh. A protein–dye hybrid system as a narrow range tunable intracellular pH sensor.
Chemical Science; 2016; DOI: 10.1039/C6SC02659A
29. Arun KB, Chandran J, Dhanya R, Krishna P, Jayamurthy P, Nisha P. A comparative evaluation of
antioxidant and antidiabetic potential of peel from young and matured potato. Food Biosci.
Elsevier; 2015;9: 36–46.
30. Arun KB, Persia F, Aswathy PS, Chandran J, Sajeev MS, Jayamurthy P, et al. Plantain peel-a
potential source of antioxidant dietary fibre for developing functional cookies. J Food Sci
Technol. Springer India; 2015; 1–10.
31. Dhanya R, Arun KB, Nisha VM, Syama HP, Nisha P, Kumar TRS, et al. Preconditioning L6
Muscle Cells with Naringin Ameliorates Oxidative Stress and Increases Glucose Uptake. PLoS
One. Public Library of Science; 2015;10.
32. Dhanya R, Arun KB, Syama HP, Nisha P, Sundaresan A, Santhosh Kumar TR, et al. Rutin and
quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl
hydrogen peroxide. Food Chem. Elsevier; 2014;158: 546–554.
33. Janu C, Kumar DR, Reshma M V, Jayamurthy P, Sundaresan A, Nisha P. Comparative Study on
the Total Phenolic Content and Radical Scavenging Activity of Common Edible Vegetable Oils.
J Food Biochem. Wiley Online Library; 2014;38: 38–49.
34. Jayamurthy P, Aparna B, Gayathri G, Nisha P. Evaluation of antioxidant potential of inflorescence
and stalk of plantain (Musa Sapientum). J Food Biochem. Wiley Online Library; 2013;37: 2–7.
35. Janu C, Padmakumari Amma KP, Nirmala Menon A, Jayamurthy P, Nisha P. Effect of enzyme
assisted extraction on quality and yield of volatile oil from black pepper and cardamom. Springer;
2012;
36. Reshma M V, Kiran CR, Nisha P, SobanKumar DR, Sundaresan A, Jayamurthy P. Trans fat
content in labeled and unlabelled Indian bakery products including fried snacks. Int Food Res J.
2012;19.
37. Sreejith S, Divya KP, Jayamurthy P, Mathew J, Anupama VN, Philips DS, et al. Heteroaromatic
donors in donor–acceptor–donor based fluorophores facilitate zinc ion sensing and cell imaging.
Photochem Photobiol Sci. RSC; 2012;11: 1715–1723.
38. Sasidharan I, Sundaresan A, Nisha VM, Kirishna MS, Raghu KG, Jayamurthy P. Inhibitory effect
of Terminalia chebula Retz. fruit extracts on digestive enzyme related to diabetes and oxidative
stress. J Enzyme Inhib Med Chem.; 2012;27: 578–586.
39. Shukla D, Saxena S, Purushothaman J, Shrivastava K, Singh M, Shukla S, et al.
Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced
pulmonary edema in rat. Eur J Pharmacol. Elsevier; 2011;656: 101–109.
40. Jayamurthy P, Suryakumar G, Shukla D, Jayamurthy H, Kasiganesan H, Kumar R,
et al. Modulation of hypoxia-induced pulmonary vascular leakage in rats by
seabuckthorn (Hippophae rhamnoides L.). Evidence-Based Complement Altern
Med. Hindawi Publishing Corporation; 2011;2011.
41. Divya KP, Sreejith S, Balakrishna B, Jayamurthy P, Anees P, Ajayaghosh A. A
Zn2+-specific fluorescent molecular probe for the selective detection of
endogenous cyanide in biorelevant samples. Chem Commun. Royal Society of
Chemistry; 2010;46: 6069–6071.
42. Shukla D, Saxena S, Jayamurthy P, Sairam M, Singh M, Jain SK, et al. Hypoxic
preconditioning with cobalt attenuates hypobaric hypoxia-induced oxidative
damage in rat lungs. High Alt Med Biol. Mary Ann Liebert, 2009;10: 57–69.
43. Geetha S, Basu M, Jayamurthy AS, Malhotra AS, Pal K, Prasad R, et al. Protective
and therapeutic potentials of seabuckthorn (Hippophae rhamnoides L.).
Seabuckthorn (Hippophae L) a Multipurp wonder plant. Daya Books; 2008;3: 245.
44. Geetha S, Jayamurthy P, Pal K, Pandey S, Kumar R, Sawhney RC.
Hepatoprotective effects of sea buckthorn (Hippophae rhamnoides L.) against
carbon tetrachloride induced liver injury in rats. J Sci Food Agric. Wiley Online
Library; 2008;88: 1592–1597.
45. Nisha P, Abdul Nazar P, Jayamurthy P. A comparative study on antioxidant
activities of different varieties of Solanum melongena. Food Chem Toxicol.
Elsevier; 2009;47: 2640–2644.
46. Jayamurthy P, Suryakumar G, Shukla D, Malhotra AS, Kasiganesan H, Kumar R,
et al. Modulatory effects of seabuckthorn (Hippophae rhamnoides L.) in
hypobaric hypoxia induced cerebral vascular injury. Brain Res Bull. Elsevier;
2008;77: 246–252.
47. Basu M, Prasad R, Jayamurthy P, Pal K, Arumughan C, Sawhney RC. Anti-
atherogenic effects of seabuckthorn ( Hippophaea rhamnoides) seed oil.
Phytomedicine. Elsevier; 2007;14: 770–777.
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Dhanya R |
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Syama HP |
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MS. Adheena M DBT JRF Email: seraadheena@gmail.com Research Area: Studying molecular mechanisms underlying ER stress-induced diabetic pathogenesis, Exploring ER stress- mediated β-cell apoptosis and impaired insulin signaling, Developing therapeutic strategies and drug discovery approaches to mitigate T2DM. Mob: 9745968636 |
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MS. Reshma K V CSIR JRF Email: reshmakv65074@gmail.com Research Area: Screening of medicinal plant extracts for Antidiabetic properties, studying molecular mechanisms and signalling pathways involved in type 2 diabetes, Exploring insulin resistance, Investigating neuroprotective effect of medicinal plant extracts Mob: 8078760141 |
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Dr Lekshmy Krishnan S Project Associate Email: slekshmykrishnan@gmail.com Research Area: Investigating the molecular mechanistic role of natural products and semi-synthetic derivatives for the management of Metabolic disorders including diabetes, inflammation and Alzheimer’s disease. Mob: 8590630389 |
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Ms. Anusha C V Junior Research Fellow Email ID: anuchandrancv1[at]gmail.com |
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Ms. Syama H P Junior Research Fellow Email ID: hp_sym[at]yahoo.com |
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Ms. Dhanya R Junior Research Fellow Email ID: dhanya_tintu[at]yahoo.co.in |
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Mrs. Jyothi C L Project Assistant Email ID: jyothick[at]gmail.com |
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Dr. Eveline M Anto Research area: ER stress, Metabolic syndrome, Natural products PhD Title: Investigation on the role of Tangeretin in alleviation of ER stress-induced diabetic complications- an in vitro approach Email: evemariaanto@gmail.com Contact No: 9539142356 |
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Dr Lekshmy Krishnan S Project Associate Research Area: Investigating the molecular mechanistic role of natural products and semi-synthetic derivatives for the management of Metabolic disorders including diabetes, inflammation and Alzheimer’s disease. PhD Title- Investigation of anti-diabetic potential of resveratrol oligomers isolated from different plants belonging to dipterocarpaceae family-a molecular mechanistic approach Email: slekshmykrishnan@gmail.com Contact No: 8590630389 |
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Dr. Anaga Nair Research Scientist, Discovery Biology, Presude Life Sciences, Bangalore Research Area: Role of natural products and natural product- derived semi-synthetic compounds in anti-glycation and diabetic complications, Bioassay development, in-vitro and in-vivo screening of telomerase targeting compounds, DNA-encoded library technology for HTS of novel chemical entities PhD Title- Trapping glycation intermediates for the modulation of diabetes and its complications: A natural product derived therapeutic approach Email – anaga.nair@presude.com/anaganair22@gmail.com Contact number – 8075215729 |
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Dr. Syama H P Assistant Professor Sr. Grade 2 School of Biosciences and Technology (SBST) Vellore Institute of Technology Research Area: Natural products and metabolic disease management - Diabetes, Cardiovascular disease, Inflammation; Nanoparticles and their in vitro and in vivo anti-tumour activity; Antimicrobial and wound healing activity; Formulation of Cosmetic products based on activity, Cancer vaccine development PhD Title- Phytochemical investigation of Syzyium cumini seeds and its impact in ameliorating life style associated diseases like diabetes, Cardiovascular-diseases and inflammation Email: Syama.hp@vit.ac.in/ hpsyama@gmail.com Contact No: |
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Dr. Dhanya R DST-INSPIRE Faculty Department of Molecular and Cellular Cardiology SCTIMST, Trivandrum. Research Area: Cardiovascular disease and Diabetes biology PhD Title: Mechanistic role of citrus flavonoids and their glycoconjugates in the management of Type 2 diabetes and its complications Contact Details: dhanyaniist@gmail.com |
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Dr. Roopasree O J
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