Microbial Processes and Technology - Highlights
Highlights
- Process for keratinase production demonstrated at tray level using chicken feather and wheat bran as substrates with a yield of 2800 IU/gDS.
Development of Probiotic Cultures and Production of Nutraceuticals & Bio-actives from Lactic Acid Bacteria
Lactic acid bacteria (LAB) are widely used as starter cultures for the production of diverse fermented foods. There is a growing interest in the incorporation of functional foods in the daily diet to achieve health promotion and disease risk reduction. Numerous studies have focused on the production of biologically active peptides as nutraceuticals and functional food ingredients due to their health benefits.
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Molecular Studies on Plant Beneficial Bacteria interactions under brackish conditions
Plant rhizosphere bacteria engage in very complex relationships with the host plants, often beneficial to the plants. Rice varieties endemic to the brackish water ecosystem have been found to harbor unique bacteria and their presence and activities have been correlated to some of the adaptive responses of plants to salinity. Understanding the relationship between such bacteria and the rice plant may help in understanding salinity tolerance in context of the microbial interactions, and may even aid development of bioinoculants that would help plants to survive salinity.
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Polyunsaturated Fatty Acids (PUFA) and Nutraceuticals from Algae
Photosynthetic organisms are the primary producers of PUFA and the major producers of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) are algae. These PUFAs are essential in the metabolism of animals as they are implicated as the starting material for synthesis of several signalling molecules. The dietary content of such fatty acids are therefore important in both humans and other animals.
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Metabolic engineering of Pichia pastoris for enhanced flux towards Squalene production
The linear polyunsaturated triterpene squalene, exists in all organisms and has immense applications in food, pharmaceutical and cosmetic industries. New applications of squalene as an enhancer are ever increasing ensuing in its growing demand. Development of a Pichia model with accelerated Farnesyl diphosphate (FPP) precursor flux towards squalene and reduced squalene drain towards ergosterol is being studied. Lipid droplets provide extra space for accumulation of squalene in cytoplasm.
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Membrane Biophysics, Membrane biology and Synthetic Biology
Understanding transport across membranes has tremendous implications in understanding how organisms/cells react to its environment. This includes the elucidation of metabolic circuits, antibiotic resistance, development of membrane potential and hence biological generation of energy and much more. Studies on synthetic membrane vesicles at MPTD is focused on understanding the transport phenomena, and also on creating functional artificial cells that mimic microorganisms
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Corynebactin, a Cyclic Catecholate Siderophore from Corynebacterium glutamicum ATCC 14067 (Brevibacterium sp. DSM 20411)
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Crystal structure of pimolin, C26H20O8
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Candida rugosa lipases: Molecular biology and versatility in biotechnology
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Organosolvent pretreatment and enzymatic hydrolysis of rice straw for the production of bioethanol
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